Spider Hemocyanin Binds Ecdysone and 20-OH-Ecdysone

Jaenicke, Elmar; Föll, Roman; Decker, Heinz

doi:10.1074/jbc.274.48.34267

Cited by 71 publications

(32 citation statements)

References 44 publications

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“…Hemocyanin as the sole respiratory protein was also involved in physiological processes such as osmoregulation, protein storage and exoskeleton formation [18,19]. In addition, Eurypelma californicum hemocyanin could bind with ecdysone, participating in hormone transfer and molting regulation [21]. Hemocyanin as a multi-function protein, besides its role as described above, was also found to be involved in defending invaders, including bacteria and fungi [15,16].…”

Section: Discussionmentioning

confidence: 99%

Cloning and characterization of the hemocyanin gene of prawn Macrobrachium nipponense

Wang¹,

Xia²,

Liu³

et al. 2012

Turk J Bioch

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Section: Discussionmentioning

confidence: 99%

Cloning and characterization of the hemocyanin gene of prawn Macrobrachium nipponense

Wang¹,

Xia²,

Liu³

et al. 2012

Turk J Bioch

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“…Binding of ecdysteroids to hemolymph proteins has been demonstrated in crustaceans and insects [14]. In the tarantula Eurypelma californicum, ecdysteroids are bound to hemocyanin [15]. Up to now, nothing is known about the biological relevance of carrier-bound ecdysteroids.…”

Section: Transport Of Ecdysteroidsmentioning

confidence: 99%

Ecdysteroid hormone action

Spindler

Honl

Tremmel

et al. 2009

Cell. Mol. Life Sci.

103

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Several reviews devoted to various aspects of ecdysone research have been published during the last few years. Therefore, this article concentrates mainly on the considerable progress in ecdysone research observed recently, and will cover the results obtained during the last 2 years. The main emphasis is put on the molecular mode of ecdysteroid receptor-mediated hormone action. Two examples of interaction with other hormonal signalling pathways are described, namely crosstalk with juvenile hormone and insulin. Some selected, recently investigated examples of the multitude of hormonal responses are described. Finally, ecological aspects and some practical applications are discussed.

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“…In invertebrates, the oxygen transport protein hemocyanin can carry non-allosterically lipids and hormones in addition to O 2 (Cunningham et al, 1999;Jaenicke et al, 2010). Indeed, early experiments have hinted at a fatty acid transport role for Mb.…”

Section: Other Functions Of Mb Poresmentioning

confidence: 99%

‘It's hollow’: the function of pores within myoglobin

Tomita

Kreutzer

Adachi

et al. 2010

Journal of Experimental Biology

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SUMMARY Despite a century of research, the cellular function of myoglobin (Mb), the mechanism regulating oxygen (O2) transport in the cell and the structure–function relationship of Mb remain incompletely understood. In particular, the presence and function of pores within Mb have attracted much recent attention. These pores can bind to Xe as well as to other ligands. Indeed, recent cryogenic X-ray crystallographic studies using novel techniques have captured snapshots of carbon monoxide (CO) migrating through these pores. The observed movement of the CO molecule from the heme iron site to the internal cavities and the associated structural changes of the amino acid residues around the cavities confirm the integral role of the pores in forming a ligand migration pathway from the protein surface to the heme. These observations resolve a long-standing controversy – but how these pores affect the physiological function of Mb poses a striking question at the frontier of biology.

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Spider Hemocyanin Binds Ecdysone and 20-OH-Ecdysone

Cited by 71 publications

References 44 publications

Cloning and characterization of the hemocyanin gene of prawn Macrobrachium nipponense

Cloning and characterization of the hemocyanin gene of prawn Macrobrachium nipponense

Ecdysteroid hormone action

‘It's hollow’: the function of pores within myoglobin

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