Spices and Odorants as TRP Channel Activators

Friedland, Kristina; Harteneck, Christian

doi:10.1007/978-3-319-26932-0_34

Cited by 8 publications

(3 citation statements)

References 98 publications

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“…Olfactory information is independently processed via the first cranial (olfactory) nerve. Since most odorants stimulate both cranial nerves I and V, mutual interactivity between these two systems takes place across multiple processing levels (Brand, 2006 ; Doty et al, 1978 ; Friedland & Harteneck, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Olfactory–trigeminal integration in the primary olfactory cortex

Karunanayaka,

Lu,

Elyan

et al. 2024

Human Brain Mapping

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Humans naturally integrate signals from the olfactory and intranasal trigeminal systems. A tight interplay has been demonstrated between these two systems, and yet the neural circuitry mediating olfactory–trigeminal (OT) integration remains poorly understood. Using functional magnetic resonance imaging (fMRI), combined with psychophysics, this study investigated the neural mechanisms underlying OT integration. Fifteen participants with normal olfactory function performed a localization task with air‐puff stimuli, phenylethyl alcohol (PEA; rose odor), or a combination thereof while being scanned. The ability to localize PEA to either nostril was at chance. Yet, its presence significantly improved the localization accuracy of weak, but not strong, air‐puffs, when both stimuli were delivered concurrently to the same nostril, but not when different nostrils received the two stimuli. This enhancement in localization accuracy, exemplifying the principles of spatial coincidence and inverse effectiveness in multisensory integration, was associated with multisensory integrative activity in the primary olfactory (POC), orbitofrontal (OFC), superior temporal (STC), inferior parietal (IPC) and cingulate cortices, and in the cerebellum. Multisensory enhancement in most of these regions correlated with behavioral multisensory enhancement, as did increases in connectivity between some of these regions. We interpret these findings as indicating that the POC is part of a distributed brain network mediating integration between the olfactory and trigeminal systems.Practitioner Points Psychophysical and neuroimaging study of olfactory–trigeminal (OT) integration. Behavior, cortical activity, and network connectivity show OT integration. OT integration obeys principles of inverse effectiveness and spatial coincidence. Behavioral and neural measures of OT integration are correlated.

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Section: Introductionmentioning

confidence: 99%

Olfactory–trigeminal integration in the primary olfactory cortex

Karunanayaka,

Lu,

Elyan

et al. 2024

Human Brain Mapping

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“…It allows for the perception of the spiciness of hot peppers or the freshness of peppermint (Filiou & al, 2015;Viana, 2011). The trigeminal system is independent from the olfactory system, i.e., it has (1) distinct chemoreceptors (e.g., TRPM8, TRPV1 (Gerhold & Bautista, 2009)), (2) distinct conveying structures (i.e., the trigeminal nerve) and (3) distinct central nervous processing centers (Friedland & Harteneck 2017;Brand, 2006). However, the trigeminal system interacts very closely with the olfactory system as most odorous substances activate both the olfactory and the trigeminal system (Doty & al.…”

Section: Introductionmentioning

confidence: 99%

Chemosensation in anxiety: the trigeminal system matters

et al. 2023

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The presence of a perceptual bias due to anxiety is well demonstrated in cognitive and sensory task for the visual and auditory modality. Event-related potentials, by their specific measurement of neural processes, have strongly contributed to this evidence. There is still no consensus as to whether such a bias exists in the chemical senses; chemosensory event-related potentials (CSERP) are an excellent tool to clarify the heterogeneous results, especially since the Late Positive Component (LPC) may be an indicator of emotional involvement after chemosensory stimulation. This research examined the association between state and trait anxiety and the amplitude and latency of pure olfactory and mixed olfactory-trigeminal LPC. In this study, 20 healthy participants (11 women) with a mean age of 24.6 years (SD=2.6) completed a validated questionnaire to measure anxiety (STAI), and CSERP were recorded during 40 pure olfactory stimulations (phenyl ethanol) and 40 mixed olfactory-trigeminal stimulations (eucalyptol). LPC latency and amplitude were measured at Cz (electrode located at midline central) for each participant. We observed a significant negative correlation between LPC latencies and the state anxiety scores for the mixed olfactory-trigeminal condition (r(18) = -.513; p = .021), but not for the pure olfactory condition. We did not observe any effect on LPC amplitudes. This study suggests that a higher level of state anxiety is related to a more rapid perceptual electrophysiological response for mixed olfactory-trigeminal stimuli but not for pure odors.

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Section: Introductionmentioning

confidence: 99%

Chemosensation in Anxiety: The Trigeminal System Matters

Fortier-Lebel¹,

Hudon²,

Boller³

et al. 2022

Preprint

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The presence of a perceptual bias due to anxiety is well demonstrated in cognitive and sensory task for the visual and auditory modality. Event-related potentials, by their specific measurement of neural processes, have strongly contributed to this evidence. There is still no consensus as to whether such a bias exists in the chemical senses; chemosensory event-related potentials (CSERP) are an excellent tool to clarify the heterogeneous results, especially since the Late Positive Component (LPC) may be an indicator of emotional involvement after chemosensory stimulation. This research examined the association between state and trait anxiety and the amplitude and latency of pure olfactory and mixed olfactory-trigeminal LPC. In this study, 20 healthy participants (11 women) with a mean age of 24.6 years (SD=2.6) completed a validated questionnaire to measure anxiety (STAI), and CSERP were recorded during 40 pure olfactory stimulations (phenyl ethanol) and 40 mixed olfactory-trigeminal stimulations (eucalyptol). LPC latency and amplitude were measured at Cz for each participant. We observed a significant negative correlation between LPC latencies and the state anxiety scores for the mixed olfactory-trigeminal condition (r(18) = -.513; p = .021), but not for the pure olfactory condition. We did not observe any effect on LPC amplitudes. This study suggests that a higher level of state anxiety is related to a more rapid perceptual electrophysiological response for mixed olfactory-trigeminal stimuli but not for pure odors.

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Spices and Odorants as TRP Channel Activators

Cited by 8 publications

References 98 publications

Olfactory–trigeminal integration in the primary olfactory cortex

Olfactory–trigeminal integration in the primary olfactory cortex

Chemosensation in anxiety: the trigeminal system matters

Chemosensation in Anxiety: The Trigeminal System Matters

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