Spice, pot, and stroke

Barber, P Alan; Anderson, Neil E.; Brust, John C.M.

doi:10.1212/wnl.0000000000000722

Cited by 5 publications

(3 citation statements)

References 12 publications

(1 reference statement)

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“…Spice's association with seizures, heart attacks, renal failure, and now both ischemic and hemorrhagic stroke makes a thoughtful, thorough history critical. 9 Although another etiology of ICH may exist (e.g., labile hypertension, occult connective tissue disease, noninflammatory vasculitis, amyloid angiopathy), our patients had an otherwise unrevealing workup (erythrocyte sedimentation rate, hs-C-reactive protein, platelets, coagulation, transthoracic/transesophageal echocardiograms, hypercoagulability panel). Nonetheless, spice may contain other, unknown components.…”

Section: Figurementioning

confidence: 76%

Hemorrhagic stroke following use of the synthetic marijuana “spice”

et al. 2015

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Section: Figurementioning

confidence: 76%

Hemorrhagic stroke following use of the synthetic marijuana “spice”

et al. 2015

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“…[11][12][13][14] In addition, stroke as a complication related to recreational and synthetic marijuana products high in delta-9-tetrahydrocannabinol has been reported in young adults and adolescents. [15][16][17][18] However, further studies are likely needed to fully understand its short-and long-term effects. To date, no long-term adverse effects have been reported from products with a high content of cannabidiol and a low content of delta-9-tetrahydrocannabinol.…”

Section: History and Backgroundmentioning

confidence: 99%

Medical Marijuana in Pediatric Neurological Disorders

Patel

2015

J Child Neurol

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Marijuana and marijuana-based products have been used to treat medical disease. Recently, derivatives of the plant have been separated or synthesized to treat various neurological disorders, many of them affecting children. Unfortunately, data are sparse in regard to treating children with neurologic illness. Therefore, formal conclusions about the potential efficacy, benefit, and adverse effects for these products cannot be made at this time. Further robust research using strong scientific methodology is desperately needed to formally evaluate the role of these products in children.

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“…Growing evidence links cannabis use to cerebrovascular disease, including aneurysmal subarachnoid hemorrhage (aSAH) 1 and acute ischemic stroke. 2 In a population-based study, the aSAH incidence was twice as high in cannabis users as in nonusers in a younger age group. 3 The pathophysiology of this association is unknown, but research suggests that multifocal intracranial stenosis, oxidative stress, and cerebral mitochondrial dysfunction are contributors.…”

mentioning

confidence: 97%