In this study, the electrical circuit equivalents of the previously designed novel CNT/MOSFET based active electrode and commonly used wet electrode are simulated by applying different biopotentials. Responses of the electrode models are compared within the certain skin surface circumstances. Fourier transforms and total harmonic distortion calculations of obtained biopotentials are examined to assess the electrodes. The simulation results demonstrate that the CNT / MOSFET based electrode predominates the wet electrode and can measure biopotentials with high quality.