Sphingosine 1-phosphate receptor 1 inhibition induces a pro-apoptotic signaling cascade in T cells
Dhaval Dixit,
Victoria M. Hallisey,
Ethan Y.S. Zhu
et al.
Abstract:Effective immunity requires a large, diverse naïve T cell repertoire circulating among lymphoid organs in search of antigen. Sphingosine 1-phosphate (S1P) and its receptor S1PR1 contribute by both directing T cell migration and supporting T cell survival. Here, we address how S1P enables T cell survival, and the implications for patients treated with S1PR1 antagonists. Contrary to expectations, we found that S1PR1 limits apoptosis by maintaining the appropriate balance of BCL2 family members via restraint of J… Show more
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