Sphingosine-1-Phosphate Metabolism and Intestinal Tumorigenesis: Lipid Signaling Strikes Again

Oskouian, Babak; Saba, Julie D.

doi:10.4161/cc.6.5.3903

Cited by 56 publications

(47 citation statements)

References 72 publications

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“…The sphingoid bases sphingosine and sphinganine were shown to preferentially inhibit breast cancer cells and eliminate stem cells from which most breast cancer cells arise (Ahn, Chang, & Schroeder, 2006). In contrast, sphingosine-1-phosphate has been shown to stimulate cell growth and suppress apoptosis by acting through G-protein coupled receptors present on mammalian cells, thus stimulating cell proliferation, angiogenesis and inhibiting apoptosis (Oskouian & Saba, 2007;Spiegel & Milstien, 2003). The enzyme responsible for sphingosine-1-phosphate synthesis, namely sphingosine kinase 1, behaves as an oncogene in experimental systems (Oskouian & Saba, 2007).…”

Section: Phospholipids and Cancermentioning

confidence: 95%

Milk intelligence: Mining milk for bioactive substances associated with human health

Mills

Ross

Hill

et al. 2011

International Dairy Journal

232

169

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Section: Phospholipids and Cancermentioning

confidence: 95%

Milk intelligence: Mining milk for bioactive substances associated with human health

Mills

Ross

Hill

et al. 2011

International Dairy Journal

232

169

View full text Add to dashboard Cite

“…Recently, compelling evidence has linked SPHK1 up-regulation to cancer development and progression (39,40), and the up-regulation of SPHK1 has been revealed in several types of solid tumors, including glioblastoma, intestinal adenoma, acute erythroleukemia, prostate cancer, and colon cancer (33 -37). It was reported that the induction of SPHK1 expression could be mediated by various mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Sphingosine Kinase-1 Expression in Human Astrocytomas Progression and Overall Patient Survival

Guan

Gong

et al. 2008

Clinical Cancer Research

134

108

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Purpose: To characterize the expression of sphingosine kinase-1 (SPHK1) in human astrocytomas and to investigate the association between SPHK1 expression and progression of astrocytomas. Experimental Design: The expression of SPHK1in normal human astrocytes, astrocytoma cell lines, and four pairs of matched astrocytoma tissues and their adjacent normal brain tissues were detected by quantitative reverse transcription-PCR and Western blot. In addition, SPHK1protein expression was examined in 243 cases of histologically characterized astrocytomas by immunohistochemistry. Statistical analyses were applied to test for prognostic and diagnostic associations. Results: SPHK1in astrocytoma cell lines was elevated at both mRNA and protein levels, and the SPHK1mRNA and protein were significantly up-regulatedby up to 6.8-and 40-fold, respectively, in primary astrocytomas compared with those in the adjacent noncancerous brain tissues. Immunohistochemical analysis showed that 100 of 243 (41.2%) paraffin-embedded archival astrocytoma biopsies exhibited high expression of SPHK1. Statistical analysis suggested that the up-regulation of SPHK1was significantly correlated with the histologic grade of astrocytoma (P = 0.000) and that patients with high SPHK1level exhibited shorter survival time (P < 0.001). Multivariate analysis revealed that SPHK1up-regulation might be an independent prognostic indicator for the survival of patients with astrocytoma. Conclusions: SPHK1might represent a novel and useful prognostic marker for astrocytoma and play a role during the development and progression of the disease.

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“…However, whereas SK1 overexpression was associated with upregulation of the antiapoptotic protein Bcl-2 (20, 21), the connection between SPL with Bcl-2 family members has never been investigated. Interestingly, the SGPL1 gene, which encodes SPL, has been reported to be significantly downregulated in human colon cancer tissues compared with normal tissues (22). Moreover, the human SGPL1 gene maps to chromosomal region 10q21 (23), which is deleted or mutated in many human tumor types (24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

et al. 2009

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Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in cancer development through stimulation of cell survival, proliferation, migration, and angiogenesis. Irreversible degradation of S1P is catalyzed by S1P lyase (SPL). The human SGPL1 gene that encodes SPL maps to a region often mutated in cancers. To investigate the effect of SPL deficiency on cell survival and transformation, the susceptibility to anticancer drugs of fibroblasts generated from SPLdeficient mouse embryos (Sgpl1

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Sphingosine-1-Phosphate Metabolism and Intestinal Tumorigenesis: Lipid Signaling Strikes Again

Cited by 56 publications

References 72 publications

Milk intelligence: Mining milk for bioactive substances associated with human health

Milk intelligence: Mining milk for bioactive substances associated with human health

Clinical Significance of Sphingosine Kinase-1 Expression in Human Astrocytomas Progression and Overall Patient Survival

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

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