Sphingosine 1‐phosphate combining with S1PR4 promotes regulatory T cell differentiation related to FAO through Nrf2/PPARα
Rui Feng,
Chuang Liu,
Zilin Cui
et al.
Abstract:Metabolism and metabolic processes have long been considered to shape the tumour immunosuppressive microenvironment. Recent research has demonstrated that T regulatory cells (Tregs) display high rates of fatty acid oxidation (FAO) and a relatively low rate of glycolysis. Sphingosine 1‐phosphate (S1P), which is a G protein signalling activator involved in immune regulation and FAO modulation, has been implicated in Treg differentiation. However, the precise relation between Treg differentiation and S1P remains … Show more
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