Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells

Lepannetier, Sophie; Zanou, Nadège; Yerna, Xavier; Emeriau, Noémie; Dufour, Inès; Masquelier, Julien; Muccioli, Giulio G.; Tajeddine, Nicolas; Gailly, Philippe

doi:10.1016/j.ceca.2016.09.002

Cited by 41 publications

(47 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, TRPC1 has shown a correlation with an increased migratory phenotype in some tumors, such as glioblastoma, osteosarcoma, thyroid, pancreatic and colon carcinoma ( Dong et al, 2010 ; Asghar et al, 2015 ; Huang et al, 2015 ; Guéguinou et al, 2016 ; Lepannetier et al, 2016 ). One of the key steps in cell migration is the establishment of a functional and morphological polarity along the axis of movement.…”

Section: Introductionmentioning

confidence: 98%

TRP Channels and Small GTPases Interplay in the Main Hallmarks of Metastatic Cancer

2020

View full text Add to dashboard Cite

Transient Receptor Potential (TRP) cations channels, as key regulators of intracellular calcium homeostasis, play a central role in the essential hallmarks of cancer. Among the multiple pathways in which TRPs may be involved, here we focus our attention on the ones involving small guanosine triphosphatases (GTPases), summarizing the main processes associated with the metastatic cascade, such as migration, invasion and tumor vascularization. In the last decade, several studies have highlighted a bidirectional interplay between TRPs and small GTPases in cancer progression: TRP channels may affect small GTPases activity via both Ca 2+ -dependent or Ca 2+ -independent pathways, and, conversely, some small GTPases may affect TRP channels activity through the regulation of their intracellular trafficking to the plasma membrane or acting directly on channel gating. In particular, we will describe the interplay between TRPC1, TRPC5, TRPC6, TRPM4, TRPM7 or TRPV4, and Rho-like GTPases in regulating cell migration, the cooperation of TRPM2 and TRPV2 with Rho GTPases in increasing cell invasiveness and finally, the crosstalk between TRPC1, TRPC6, TRPM8, TRPV4 and both Rho- and Ras-like GTPases in inducing aberrant tumor vascularization.

show abstract

Section: Introductionmentioning

confidence: 98%

TRP Channels and Small GTPases Interplay in the Main Hallmarks of Metastatic Cancer

2020

View full text Add to dashboard Cite

show abstract

“…TRPC1 is also involved in store-operated calcium entry in cooperation with Orai1 channel and activated by STIM1, a sensor of Ca 2+ contents in the endoplasmic reticulum ( Ambudkar et al, 2007 ; Cheng et al, 2008 ; Louis et al, 2008 ; Kim et al, 2009 ; Tajeddine and Gailly, 2012 ; Ong and Ambudkar, 2017 ). TRPC1 can be directly activated by phosphatidylinositol 3,4,5-trisphosphate (PIP3), by phosphorylation by PKC ( Ahmmed et al, 2004 ; Saleh et al, 2009 ) or through the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2 ) and/or concomitant generation of DAG ( Albert, 2011 ) or other lipids such as sphingosine-1-P ( Lepannetier et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory

Lepannetier

Gualdani

Tempesta

et al. 2018

Front. Cell. Neurosci.

Self Cite

View full text Add to dashboard Cite

Group I metabotropic glutamate receptors, in particular mGluR5, have been implicated in various forms of synaptic plasticity that are believed to underlie declarative memory. We observed that mGluR5 specifically activated a channel containing TRPC1, an isoform of the canonical family of transient receptor potential (TRPC) channels highly expressed in CA1-3 regions of the hippocampus. TRPC1 is able to form tetrameric complexes with TRPC4 and/or TRPC5 isoforms. TRPC1/4/5 complexes have recently been involved in the efficiency of synaptic transmission in the hippocampus. We therefore used a mouse model devoid of TRPC1 expression to investigate the involvement of mGluR5-TRPC1 pathway in synaptic plasticity and memory formation. Trpc1-/- mice showed alterations in spatial working memory and fear conditioning. Activation of mGluR increased synaptic excitability in neurons from WT but not from Trpc1-/- mice. LTP triggered by a theta burst could not maintain over time in brain slices from Trpc1-/- mice. mGluR-induced LTD was also impaired in these mice. Finally, acute inhibition of TRPC1 by Pico145 on isolated neurons or on brain slices mimicked the genetic depletion of Trpc1 and inhibited mGluR-induced entry of cations and subsequent effects on synaptic plasticity, excluding developmental or compensatory mechanisms in Trpc1-/- mice. In summary, our results indicate that TRPC1 plays a role in synaptic plasticity and spatial working memory processes.

show abstract

“…For instance, EGF and IL-1 signaling pathways may enhance S1P-dependent expression of PAI-1 and uPAR [99,201]. In addition, PDGF-induced GBM chemotaxis is dependent on S1P, which in turn activates the transient receptor potential channel TRPC1, leading to the entry of Ca 2+ and increased cell invasivity [211].…”

Section: S1p In the Cancer Microenvironment Promotes Invasive Behaviourmentioning

confidence: 99%

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

Riboni

Hadi

Navone

et al. 2020

Cells

View full text Add to dashboard Cite

As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer extracellular milieu. In this review, we have a particular focus on glioblastoma, representative of a highly aggressive and deleterious neoplasm in humans. First, we highlight recent advances and emerging concepts for how tumor cells and different recruited normal cells contribute to the sphingosine-1-phosphate enrichment in the cancer microenvironment. Then, we describe and discuss how sphingosine-1-phosphate signaling contributes to favor cancer hallmarks including enhancement of proliferation, stemness, invasion, death resistance, angiogenesis, immune evasion and, possibly, aberrant metabolism. We also discuss the potential of how sphingosine-1-phosphate control mechanisms are coordinated across distinct cancer microenvironments. Further progress in understanding the role of S1P signaling in cancer will depend crucially on increasing knowledge of its participation in the tumor microenvironment.

show abstract

Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells

Cited by 41 publications

References 58 publications

TRP Channels and Small GTPases Interplay in the Main Hallmarks of Metastatic Cancer

TRP Channels and Small GTPases Interplay in the Main Hallmarks of Metastatic Cancer

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

Contact Info

Product

Resources

About