Sphingomyelin Phosphodiesterase Acid-Like 3b is Essential for Toll-Like Receptor 3 Signaling in Human Podocytes

Identification of crucial inflammaging related risk factors in multiple sclerosis

“…The Markov Chain Monte Carlo (MCMC) method was used to assess the sensitivity indices between inflammaging and MS. As a result, the 35 sensitive triples (by calculating the absolute difference frequency) were shown in Table 3 (Sarasin-Filipowicz et al, 2009 ; Chen and D'Mello, 2010 ; Bergbold and Lemberg, 2013 ; Liu et al, 2013 ; Malhotra et al, 2013 ; Wan, 2014 ; Charbit et al, 2015 ; Fusco et al, 2015 ; An et al, 2017 ; Arentsen et al, 2017 ; Maridas et al, 2017 ; Mathur et al, 2017 ; Xiao et al, 2019 ; Immler et al, 2020 ; Sato et al, 2020 ; Tong et al, 2020 ; Buhelt et al, 2021 ; Correale, 2021 ; Fadul et al, 2021 ; Ma et al, 2021 ; Peng et al, 2021 ; Bogacka et al, 2022 ; Franceschi et al, 2022 ; Hjæresen et al, 2022 ; Khurana and Goswami, 2022 ; Liu S. et al, 2022 ; Schebb et al, 2022 ; Watanabe et al, 2022 ; Saeidi et al, 2023 ). For example, the sensitive triple with maximum difference was “TMPRSS13-USP18-DCHS2” (the absolute difference value was 0.270469).…”

Porcine reproductive and respiratory syndrome virus upregulates SMPDL3B to promote viral replication by modulating lipid metabolism

“… 56 SMPDL3B has been implicated in many cellular functions, and recent evidence suggests that SMPDL3B is involved in TLR signaling. 26 , 57 Moreover, SMPDL3B mediates radiation-induced damage to renal podocytes 58 and is also involved in diabetic kidney disease. 56 , 59 Although studies have highlighted the significance of SMPDL3B in maintaining normal lipid metabolism, the mechanism by which SMPDL3B functions as a host factor during PRRSV infection remains unclear.…”