Sphingomyelin-based PEGylation Cu (DDC)2 liposomes prepared via the dual function of Cu2+ for cancer therapy: Facilitating DDC loading and exerting synergistic antitumor effects

Establishment and validation of a sensitive LC–MS/MS method for the quantification of KRASG12C protein PROTAC molecule LC‐2 in rat plasma and its application to in vivo pharmacokinetic studies of LC‐2 PEGylated liposomes

“…The above results indicated that PEGylated liposomes were able to prolong the retention time of medications in vivo . The long‐term retention of liposomes could arise from the PEG layer covering the surface of liposomes, which preserved high colloidal stability and assisted in preventing reticuloendothelial system phagocytosis to prolong the circulation duration in vivo , which may be responsible for the long‐term retention of liposomes (Liu et al, 2022). Significantly, the AUC 0– t (μ g/L h) and AUC 0–∞ (μ g/L h) LC‐2 of PEGylated liposomes were almost 50 times that of LC‐2 solution.…”

“…Spiced (ng/ml) LC-2(n = 5) Mean found concentration (ng/ml) Precision (RSD, %) Accuracy (RE, %) reticuloendothelial system phagocytosis to prolong the circulation duration in vivo, which may be responsible for the long-term retention of liposomes (Liu et al, 2022). Significantly, the AUC 0-t (μ g/L h) and AUC 0-∞ (μ g/L h) LC-2 of PEGylated liposomes were almost 50 times that of LC-2 solution.…”

The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics

“…DSF is metabolized mainly in the liver, where disulfide bonds are broken to produce two molecules of diethyldithiocarbamate (DDC) [ 30 ]. Acidic environments cause DDC to form a complex with Cu 2+ resulting in Cu (DDC)2 [ 31 , 32 ]. Cu (DDC)2 is more stable than DDC and has its own antitumor activity.…”

“…Liu et al used biotin-PEG-DSPE to modify DSF-lipid NPs, enhancing tumor targeting via biotin receptors in cancer cells. In vivo studies showed that biotin-PEG-DSPE modified DSF lipid NPs effectively inhibited breast cancer growth in mice tumor models [ 92 ].…”

Research on the loading and release kinetics of the vincristine sulfate liposomes and its anti-breast cancer activity

“…Liposomes, as the drug delivery systems, show numerous advantages, e.g. , high drug loading ability, targeting capability, improved drug stability, high biocompatibility, increased drug potency, as well as reduced toxicity( Liu et al, 2022 ; Monteiro et al, 2014 ).…”