Sphingolipids Modulate Secretion of Glycosylphosphatidylinositol-Anchored Plasmodesmata Proteins and Callose Deposition

Iswanto, Arya Bagus Boedi; Shon, Jong Cheol; Liu, Kwang-Hyeon; Vu, Minh Huy; Kumar, Ritesh; Kim, Jae‐Yean

doi:10.1104/pp.20.00401

Cited by 21 publications

(29 citation statements)

References 85 publications

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“…Effects of temperature on PD structure and conductivity were also observed in maize ( Bilska and Sowinski, 2010 ). Recent progress made in the analysis of PD structure, composition, and regulation ( Wu et al, 2018 ; Brault et al, 2019 ; Grison et al, 2019 ; Huang et al, 2019 ; Cheval et al, 2020 ; Iswanto et al, 2020 ; Liu et al, 2020 ) may facilitate future research in model systems such as N. benthamiana and Arabidopsis to reveal the impact of increasing temperature on PD proteins and membranes and whether such changes correlate with an altered flow of PD targeted and non-targeted macromolecules (e.g., GFP) through the pore.…”

Section: Introductionmentioning

confidence: 99%

Potential Impact of Global Warming on Virus Propagation in Infected Plants and Agricultural Productivity

2021

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The increasing pace of global warming and climate instability will challenge the management of pests and diseases of cultivated plants. Several reports have shown that increases in environmental temperature can enhance the cell-to-cell and systemic propagation of viruses within their infected hosts. These observations suggest that earlier and longer periods of warmer weather may cause important changes in the interaction between viruses and their host’s plants, thus posing risks of new viral diseases and outbreaks in agriculture and the wild. As viruses target plasmodesmata (PD) for cell-to-cell spread, these cell wall pores may play yet unknown roles in the temperature-sensitive regulation of intercellular communication and virus infection. Understanding the temperature-sensitive mechanisms in plant-virus interactions will provide important knowledge for protecting crops against diseases in a warmer climate.

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Section: Introductionmentioning

confidence: 99%

Potential Impact of Global Warming on Virus Propagation in Infected Plants and Agricultural Productivity

2021

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“…FB1 and myriocin are sphingolipid inhibitors that alter sphingolipid content [ 33 ]. FB1 results in an increase in simple sphingolipids (LCBs) and a decrease in complex sphingolipids in Arabidopsis [ 33 ]. This condition also occurred in FB1 treated cotton fibers and embryos [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Sphingosine Promotes Embryo Biomass in Upland Cotton: A Biochemical and Transcriptomic Analysis

et al. 2021

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Sphingolipids are essential membrane components and signal molecules, but their regulatory role in cotton embryo growth is largely unclear. In this study, we evaluated the effects of treatment with the sphingolipid synthesis inhibitor fumonisin B1 (FB1), the serine palmityl transferase (SPT) inhibitor myriocin, the SPT sphingolipid product DHS (d18:0 dihydrosphingosine), and the post-hydroxylation DHS product PHS (t18:0 phytosphingosine) on embryo growth in culture, and performed comparative transcriptomic analysis on control and PHS-treated samples. We found that FB1 could inhibit cotton embryo development. At the five-day ovule/embryo developmental stage, PHS was the most abundant sphingolipid. An SPT enzyme inhibitor reduced the fresh weight of embryos, while PHS had the opposite effect. The transcriptomic analysis identified 2769 differentially expressed genes (1983 upregulated and 786 downregulated) in the PHS samples. A large number of transcription factors were highly upregulated, such as zinc finger, MYB, NAC, bHLH, WRKY, MADS, and GRF in PHS-treated samples compared to controls. The lipid metabolism and plant hormone (auxin, brassinosteroid, and zeatin) related genes were also altered. Our findings provide target metabolites and genes for cotton seed improvement.

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“…Indeed, lateral segregation of lipids occurs at PD which accumulate sterols and VLCFA‐SLs at the entry of the channel where the PD callose binding protein 1 (PDCB1) and the PD Β‐glucanase 2 (PDBG2), two GPI‐anchored proteins involved in callose homeostasis, are located [137–139]. Recently, it was shown that while the localization of PDCB1 and PDBG2 at PD depends on SLs, the localization of the PD‐located protein 1 (PDLP1), a transmembrane receptor, was not [140,141]. Consistently, the regulation of free diffusion by callose deposition is dependent on SLs content [140].…”

Section: Function Of Sls At Membrane Contact Sites and Cell‐to‐cell Cmentioning

confidence: 99%

“…OSBPs are involved in sterols/PI(4)P homeostasis and whether SLs could be involved in this proteins involved in callose homeostasis, are located [138][139][140] . Recently, it was shown that while the localization of PDCB1 and PDBG2 at PD depends on SLs, the localization of the PD-LOCATED PROTEIN 1 (PDLP1), a transmembrane receptor, was not 141,142 . Consistently, the regulation of free diffusion by callose deposition is dependent on SLs content 141 .…”

Section: Function Of Sls At Membrane Contact Sites and Cell-to-cell Cmentioning

confidence: 99%

“…Recently, it was shown that while the localization of PDCB1 and PDBG2 at PD depends on SLs, the localization of the PD‐located protein 1 (PDLP1), a transmembrane receptor, was not [140,141]. Consistently, the regulation of free diffusion by callose deposition is dependent on SLs content [140]. Recently, another study further detailed the SL composition of PD and described an enrichment at PD in saturated LCB, especially sphinganine (d18:0) and phytosphingosine (t18:0) [142].…”

Section: Function Of Sls At Membrane Contact Sites and Cell‐to‐cell Cmentioning

confidence: 99%

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Sphingolipids in plants: a guidebook on their function in membrane architecture, cellular processes, and environmental or developmental responses

et al. 2020

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Sphingolipids are fundamental lipids involved in various cellular, developmental and stressresponse processes. As such, they orchestrate not only vital molecular mechanisms of living cells but also act in diseases, thus qualifying as potential pharmaceutical targets. Sphingolipids are universal to eukaryotes and are also present in some prokaryotes. Some sphingolipid structures are conserved between animals, plants and fungi, whereas others are found only in plants and fungi. In plants, the structural diversity of sphingolipids, as well as their downstream effectors and molecular and cellular mechanisms of action, are of tremendous interest to both basic and applied researchers, as about half of all small molecules in clinical use originate from plants. Here we review recent advances towards a better understanding of the biosynthesis of sphingolipids, the diversity in their structures as well as their functional roles in membrane architecture, cellular processes such as membrane trafficking and cell polarity, and cell responses to environmental or developmental signals.

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Sphingolipids Modulate Secretion of Glycosylphosphatidylinositol-Anchored Plasmodesmata Proteins and Callose Deposition

Cited by 21 publications

References 85 publications

Potential Impact of Global Warming on Virus Propagation in Infected Plants and Agricultural Productivity

Potential Impact of Global Warming on Virus Propagation in Infected Plants and Agricultural Productivity

Sphingosine Promotes Embryo Biomass in Upland Cotton: A Biochemical and Transcriptomic Analysis

Sphingolipids in plants: a guidebook on their function in membrane architecture, cellular processes, and environmental or developmental responses

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