2021
DOI: 10.1016/j.cmet.2021.06.006
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Sphingolipids in metabolic disease: The good, the bad, and the unknown

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Cited by 128 publications
(129 citation statements)
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References 125 publications
(154 reference statements)
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“…De novo sphingolipid synthesis requires several enzymatic steps performed by enzymes such as ceramide synthases (CerS), serine palmitoyl-CoA transferase (SPT), 3-ketosphinganine reductase (KSR) and dihydroceramide desaturase (DES), which are continuously explored for their pharmacological potential as targets in certain metabolic diseases [13]. The ceramide biosynthesis pathway starts with the condensation of palmitoyl-CoA and serine, to produce 3-ketosphinganine, a reaction that is catalyzed by SPT [14]. 3-ketosphinganine is then reduced to sphinganine via KSR.…”
Section: Ceramidesmentioning
confidence: 99%
“…De novo sphingolipid synthesis requires several enzymatic steps performed by enzymes such as ceramide synthases (CerS), serine palmitoyl-CoA transferase (SPT), 3-ketosphinganine reductase (KSR) and dihydroceramide desaturase (DES), which are continuously explored for their pharmacological potential as targets in certain metabolic diseases [13]. The ceramide biosynthesis pathway starts with the condensation of palmitoyl-CoA and serine, to produce 3-ketosphinganine, a reaction that is catalyzed by SPT [14]. 3-ketosphinganine is then reduced to sphinganine via KSR.…”
Section: Ceramidesmentioning
confidence: 99%
“…They are also part of cell membrane, where they influence vesicular transport, membrane receptors, and exosome secretion [29]. Thus, ceramides are implicated in both intracellular and cell-to-cell signaling [31]. Ceramides synthesis and accumulation are influenced by multiple factors, which include excessive supply of substrates, systemic inflammation, oxidative stress and the microbiome [31].…”
Section: Ceramides In Cardiometabolic Health and Diseasesmentioning
confidence: 99%
“…Thus, ceramides are implicated in both intracellular and cell-to-cell signaling [31]. Ceramides synthesis and accumulation are influenced by multiple factors, which include excessive supply of substrates, systemic inflammation, oxidative stress and the microbiome [31]. In obesity, levels of Tumor Necrosis Factor-Alpha (TNF-α) are elevated, and Toll-like receptors (TLRs) are stimulated by excess of fatty acids [32].…”
Section: Ceramides In Cardiometabolic Health and Diseasesmentioning
confidence: 99%
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“…Conditional DAMPs include lysophospholipids, hyperhomocysteinemia (14)(15)(16)(17)(28)(29)(30), and succinate (27) among others. Lysophospholipids are a group of bioactive lipids; some of which are pro-inflammatory molecules (31,32), such as lysophosphatidylcholines (LPCs, lysoPC) (23,33,34), lysophosphatidic acid (LPA) (34)(35)(36), lysophosphatidylinositols (LPIs, lysoPIs) (19), and sphingosine-1-phosphate (37). LPA, LPCs, and LPIs are the characteristics of atherosclerotic aorta plaque in apolipoprotein E deficient (ApoE −/− ) and low-density lipoprotein receptor (LDLR −/− ) mice.…”
Section: Introductionmentioning
confidence: 99%