Sphingolipids and their role in health and disease in the central nervous system

Leal, Andrés Felipe; Suárez, Diego; Peña, Olga Yaneth Echeverri; Albarracín, Sonia Luz; Alméciga-Díaz, Carlos J.; Espejo-Mojica, Ángela Johana

doi:10.1016/j.jbior.2022.100900

Cited by 5 publications

(5 citation statements)

References 144 publications

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“…It is widely known that SLs are involved in brain development, changes in lipids metabolism might results in altered lipid composition that can lead to the development of neurological and psychiatric diseases (Hussain et al, 2019; Leal et al, 2022; D. Yang et al, 2022). Furthermore, exposure to an HFD formula during the early stages of development also increases the risk of developing mental and behavioral disorders in offspring after birth (Cortés‐Albornoz et al, 2021; Gawlińska et al, 2021; Mitchell et al, 2022).…”

Section: Diet Modulates Ceramides Metabolism and Susceptibility To Ps...mentioning

confidence: 99%

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Contribution of ceramides metabolism in psychiatric disorders

Bernal-Vega

García-Juárez

Camacho‐Morales

2023

Journal of Neurochemistry

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Psychiatric disorders affect 970 million people worldwide, representing a significant source of disability. Although the underlying neurobiological traits for these disorders are not fully understood, a complex interplay between psychological, environmental, and biological factors contributes to their outcomes. Recent advances in lipidomic analysis and artificial intelligence algorithms have improved the identification of selective lipid species modulating the susceptibility to mental disorders. Sphingolipids (SLs) and ceramides‐related SLs are among the most abundant lipids species in the brain that support major key pathways during neurodevelopment and brain plasticity. High levels of ceramides in plasma and brain contribute to psychiatric illness susceptibility in humans and animal models. However, the neuropathological mechanism regarding the involvement of ceramides in these disorders remain inconclusive. The brain is highly susceptible to nutritional insults, which could lead to functional impairment and influence the development and progression of psychiatric disorders. While the brain relies on glucose metabolism to support its physiological needs, a selective nutrient formula appears to have greater effects on brain health than others. For instance, consumption of high‐energy diets is associated with brain anatomical, physiological, and metabolic changes, including ceramides metabolism. Herein, we will address the contribution of ceramides metabolism as a modulator of major psychiatric disorders such as depression, anxiety, bipolar disorder, schizophrenia, and attention deficit‐hyperactivity disorder. We will also describe molecular and cellular targets of ceramides metabolism assisting the maintenance and progression of psychiatric disorders and their modulation by dietary formulas as non‐pharmacologic treatments.

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Section: Diet Modulates Ceramides Metabolism and Susceptibility To Ps...mentioning

confidence: 99%

mentioning

confidence: 99%

Contribution of ceramides metabolism in psychiatric disorders

Bernal-Vega

García-Juárez

Camacho‐Morales

2023

Journal of Neurochemistry

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“…On the other hand, the contribution of other lipid types such as glycolipids or sphingolipids must not be underestimated and would deserve a dedicated study. For example, sphingolipids have been shown to be key in the formation of highly rigid gel domains, are involved in important physiological processes and may contribute to the action of several antifungal agents (F. C. Santos et al, 2020 ; Aresta-Branco et al, 2011 ; Vecer et al, 2014 ; Körner and Fröhlich, 2022 ; Olsen and Færgeman, 2017 ; Leal and Suarez. 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of rhamnolipids on fungal membrane models as described by their interactions with phospholipids and sterols: An in silico study

et al. 2023

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Introduction: Rhamnolipids (RLs) are secondary metabolites naturally produced by bacteria of the genera Pseudomonas and Burkholderia with biosurfactant properties. A specific interest raised from their potential as biocontrol agents for crop culture protection in regard to direct antifungal and elicitor activities. As for other amphiphilic compounds, a direct interaction with membrane lipids has been suggested as the key feature for the perception and subsequent activity of RLs.Methods: Molecular Dynamics (MD) simulations are used in this work to provide an atomistic description of their interactions with different membranous lipids and focusing on their antifungal properties.Results and discussion: Our results suggest the insertion of RLs into the modelled bilayers just below the plane drawn by lipid phosphate groups, a placement that is effective in promoting significant membrane fluidification of the hydrophobic core. This localization is promoted by the formation of ionic bonds between the carboxylate group of RLs and the amino group of the phosphatidylethanolamine (PE) or phosphatidylserine (PS) headgroups. Moreover, RL acyl chains adhere to the ergosterol structure, forming a significantly higher number of van der Waals contact with respect to what is observed for phospholipid acyl chains. All these interactions might be essential for the membranotropic-driven biological actions of RLs.

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“…Sphingolipidoses are a group of inherited lysosomal storage disorders caused by deficiency of lysosomal enzymes, such as β-galactosylcerebrosidase in Krabbe disease, β-glucocerebrosidase in Gaucher disease, Globotriaosylceramidase in Fabry disease and acid sphingomyelinase in Niemann Pick type A&B [ 14 , 15 ]. Patients deficient in these enzymes show significant accumulation of its immediate sphingolipid precursor such as β-galactosylceramide and its corresponding metabolic deacylated lyso-form, galactosylsphingosine (psychosine) in Krabbe disease.…”

Section: Introductionmentioning

confidence: 99%

Lipid Polarization during Cytokinesis

Govind

Acharya

2022

Cells

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The plasma membrane of eukaryotic cells is composed of a large number of lipid species that are laterally segregated into functional domains as well as asymmetrically distributed between the outer and inner leaflets. Additionally, the spatial distribution and organization of these lipids dramatically change in response to various cellular states, such as cell division, differentiation, and apoptosis. Division of one cell into two daughter cells is one of the most fundamental requirements for the sustenance of growth in all living organisms. The successful completion of cytokinesis, the final stage of cell division, is critically dependent on the spatial distribution and organization of specific lipids. In this review, we discuss the properties of various lipid species associated with cytokinesis and the mechanisms involved in their polarization, including forward trafficking, endocytic recycling, local synthesis, and cortical flow models. The differences in lipid species requirements and distribution in mitotic vs. male meiotic cells will be discussed. We will concentrate on sphingolipids and phosphatidylinositols because their transbilayer organization and movement may be linked via the cytoskeleton and thus critically regulate various steps of cytokinesis.

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Sphingolipids and their role in health and disease in the central nervous system

Cited by 5 publications

References 144 publications

Contribution of ceramides metabolism in psychiatric disorders

Contribution of ceramides metabolism in psychiatric disorders

The effect of rhamnolipids on fungal membrane models as described by their interactions with phospholipids and sterols: An in silico study

Lipid Polarization during Cytokinesis

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