Sphingolipid metabolism and its relationship with cardiovascular, renal and metabolic diseases

Hernández-Bello, Fernando; Franco, Martha; Pérez-Méndez, Óscar; Donis-Maturano, Luis; Zarco-Olvera, Gabriela; Bautista-Pérez, Rocı́o

doi:10.24875/acme.m23000379

Cited by 2 publications

(3 citation statements)

References 96 publications

(112 reference statements)

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“…SM is synthesized by the transfer of a phosphocholine head group from phosphatidylcholine to Cer, while GlcCer is synthesized by the addition of a glucosyl group to the hydroxyl headgroup of Cer. Gangliosides are synthesized by the stepwise addition of different sugar moieties to Cer ( Hernández-Bello et al, 2023 ).…”

Section: Sphingolipid Metabolismmentioning

confidence: 99%

“…Sphingolipids have emerged as key players in various diseases, spanning cancer, neurodegenerative disorders, metabolic diseases, cardiovascular conditions, inflammatory disorders, and infectious diseases ( Yu et al, 2012 ; Trayssac et al, 2018 ; Wang et al, 2021b ; Hernández-Bello et al, 2023 ). In cancer, dysregulated sphingolipid metabolism contributes to cell proliferation, survival, angiogenesis, and metastasis ( Ghandour et al, 2021 ).…”

Section: Sphingolipids At the Interface Of Multiple Diseasesmentioning

confidence: 99%

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Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology

Jamjoum,

Majumder,

Issleny

et al. 2024

Front. Physiol.

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Metabolic pathways are complex and intertwined. Deficiencies in one or more enzymes in a given pathway are directly linked with genetic diseases, most of them having devastating manifestations. The metabolic pathways undertaken by sphingolipids are diverse and elaborate with ceramide species serving as the hubs of sphingolipid intermediary metabolism and function. Sphingolipids are bioactive lipids that serve a multitude of cellular functions. Being pleiotropic in function, deficiency or overproduction of certain sphingolipids is associated with many genetic and chronic diseases. In this up-to-date review article, we strive to gather recent scientific evidence about sphingolipid metabolism, its enzymes, and regulation. We shed light on the importance of sphingolipid metabolism in a variety of genetic diseases and in nervous and immune system ailments. This is a comprehensive review of the state of the field of sphingolipid biochemistry.

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Section: Sphingolipid Metabolismmentioning

confidence: 99%

Section: Sphingolipids At the Interface Of Multiple Diseasesmentioning

confidence: 99%

Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology

Jamjoum,

Majumder,

Issleny

et al. 2024

Front. Physiol.

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show abstract

“…These biologically active molecules have been implicated in the regulation of various cellular processes, including inflammation, apoptosis, cell proliferation, autophagy, and lipid metabolism [ 4 , 19 , 20 ]. They have also emerged as key players in metabolic diseases such as diabetes, cardiovascular diseases, and neurodegenerative disorders [ 4 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Circulating Sphingolipids and Glucose Homeostasis: An Update

Ali-Berrada,

Guitton,

Tan-Chen

et al. 2023

IJMS

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Sphingolipids are a family of lipid molecules produced through different pathways in mammals. Sphingolipids are structural components of membranes, but in response to obesity, they are implicated in the regulation of various cellular processes, including inflammation, apoptosis, cell proliferation, autophagy, and insulin resistance which favors dysregulation of glucose metabolism. Of all sphingolipids, two species, ceramides and sphingosine-1-phosphate (S1P), are also found abundantly secreted into the bloodstream and associated with lipoproteins or extracellular vesicles. Plasma concentrations of these sphingolipids can be altered upon metabolic disorders and could serve as predictive biomarkers of these diseases. Recent important advances suggest that circulating sphingolipids not only serve as biomarkers but could also serve as mediators in the dysregulation of glucose homeostasis. In this review, advances of molecular mechanisms involved in the regulation of ceramides and S1P association to lipoproteins or extracellular vesicles and how they could alter glucose metabolism are discussed.

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Sphingolipid metabolism and its relationship with cardiovascular, renal and metabolic diseases

Cited by 2 publications

References 96 publications

Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology

Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology

Circulating Sphingolipids and Glucose Homeostasis: An Update

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