Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls

Chen, Jia; Li, Zhimin; Cheng, Yi; Gao, Chunsheng; Guo, Long; Wang, Tuhong; Xu, Jianping

doi:10.3390/jof6040312

Cited by 20 publications

(13 citation statements)

References 282 publications

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“…For example, sphinganine-analog mycotoxins including fumonisins and AAL-toxins produced by plant pathogenic fungi in the Fusarium genus and in Alternaria alternata f. sp. Lycopersici respectively have diverse cytotoxicity and phytotoxicity and are a destructive force to crop production worldwide ( Chen J. et al, 2020 ). On the other hand, there are many examples of bacteria and fungi that produce plant growth – promoting SMs.…”

Section: Plant Microbiomes Contribute To the Productions Of Psmsmentioning

confidence: 99%

Linking Plant Secondary Metabolites and Plant Microbiomes: A Review

et al. 2021

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Plant secondary metabolites (PSMs) play many roles including defense against pathogens, pests, and herbivores; response to environmental stresses, and mediating organismal interactions. Similarly, plant microbiomes participate in many of the above-mentioned processes directly or indirectly by regulating plant metabolism. Studies have shown that plants can influence their microbiome by secreting various metabolites and, in turn, the microbiome may also impact the metabolome of the host plant. However, not much is known about the communications between the interacting partners to impact their phenotypic changes. In this article, we review the patterns and potential underlying mechanisms of interactions between PSMs and plant microbiomes. We describe the recent developments in analytical approaches and methods in this field. The applications of these new methods and approaches have increased our understanding of the relationships between PSMs and plant microbiomes. Though the current studies have primarily focused on model organisms, the methods and results obtained so far should help future studies of agriculturally important plants and facilitate the development of methods to manipulate PSMs–microbiome interactions with predictive outcomes for sustainable crop productions.

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Section: Plant Microbiomes Contribute To the Productions Of Psmsmentioning

confidence: 99%

Linking Plant Secondary Metabolites and Plant Microbiomes: A Review

et al. 2021

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“…Notably, the fumonisin B family is the main and most toxic family. Fumonisin B 1 (FB 1 ) and fumonisin B 2 (FB 2 ) are the most abundant and most toxic variants that naturally contaminate maize, accounting for 70–80% and 15–25% of the total number of fumonisins [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Toxic Mechanism and Biological Detoxification of Fumonisins

Wang

et al. 2022

Toxins

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Food safety is related to the national economy and people’s livelihood. Fumonisins are widely found in animal feed, feed raw materials, and human food. This can not only cause economic losses in animal husbandry but can also have carcinogenicity or teratogenicity and can be left in animal meat, eggs, and milk which may enter the human body and pose a serious threat to human health. Although there are many strategies to prevent fumonisins from entering the food chain, the traditional physical and chemical methods of mycotoxin removal have some disadvantages, such as an unstable effect, large nutrient loss, impact on the palatability of feed, and difficulty in mass production. As a safe, efficient, and environmentally friendly detoxification technology, biological detoxification attracts more and more attention from researchers and is gradually becoming an accepted technique. This work summarizes the toxic mechanism of fumonisins and highlights the advances of fumonisins in the detoxification of biological antioxidants, antagonistic microorganisms, and degradation mechanisms. Finally, the future challenges and focus of the biological control and degradation of fumonisins are discussed.

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“…FB1-elicited ROS production exhibited different tendencies after 72-h treatment under both mycotoxin concentrations in tomato. ROS generation is considered to be the major cause leading to cell death under various biotic and abiotic stresses (Ambastha et al 2018;Chen et al 2020). Recently, significant H 2 O 2 accumulation was reported upon FB1 infiltration in the leaves of Phaseolus vulgaris (Zavafer et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Fumonisin B1-Induced Oxidative Burst Perturbed Photosynthetic Activity and Affected Antioxidant Enzymatic Response in Tomato Plants in Ethylene-Dependent Manner

Iqbal

Czékus

Angeli³

et al. 2022

J Plant Growth Regul

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Fumonisin B1 (FB1) is a harmful mycotoxin produced by Fusarium species, which results in oxidative stress leading to cell death in plants. FB1 perturbs the metabolism of sphingolipids and causes growth and yield reduction. This study was conducted to assess the role of ethylene in the production and metabolism of reactive oxygen species in the leaves of wild type (WT) and ethylene receptor mutant Never ripe (Nr) tomato and to elucidate the FB1-induced phytotoxic effects on the photosynthetic activity and antioxidant mechanisms triggered by FB1 stress. FB1 exposure resulted in significant ethylene emission in a concentration-dependent manner in both genotypes. Moreover, FB1 significantly affected the photosynthetic parameters of PSII and PSI and activated photoprotective mechanisms, such as non-photochemical quenching in both genotypes, especially under 10 µM FB1 concentration. Further, the net photosynthetic rate and stomatal conductance were significantly reduced in both genotypes in a FB1 dose-dependent manner. Interestingly, lipid peroxidation and loss of cell viability were also more pronounced in WT as compared to Nr leaves indicating the role of ethylene in cell death induction in the leaves. Thus, FB1-induced oxidative stress affected the working efficiency of PSI and PSII in both tomato genotypes. However, ethylene-dependent antioxidant enzymatic defense mechanisms were activated by FB1 and showed significantly elevated levels of superoxide dismutase (18.6%), ascorbate peroxidase (129.1%), and glutathione S-transferase activities (66.62%) in Nr mutants as compared to WT tomato plants confirming the role of ethylene in the regulation of cell death and defense mechanisms under the mycotoxin exposure.

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Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls

Cited by 20 publications

References 282 publications

Linking Plant Secondary Metabolites and Plant Microbiomes: A Review

Linking Plant Secondary Metabolites and Plant Microbiomes: A Review

Toxic Mechanism and Biological Detoxification of Fumonisins

Fumonisin B1-Induced Oxidative Burst Perturbed Photosynthetic Activity and Affected Antioxidant Enzymatic Response in Tomato Plants in Ethylene-Dependent Manner

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