Let Ω be an irreducible bounded symmetric domain of rank r in C d . Let K be the maximal compact subgroup of the identity component G of the biholomorphic automorphism group of the domain Ω. The group K consisting of linear transformations acts naturally on any d-tuple T = (T 1 , . . . , T d ) of commuting bounded linear operators. If the orbit of this action modulo unitary equivalence is a singleton, then we say that T is K-homogeneous. In this paper, we obtain a model for a certain class of K-homogeneous d-tuple T as the operators of multiplication by the coordinate functions z 1 , . . . , z d on a reproducing kernel Hilbert space of holomorphic functions defined on Ω. Using this model we obtain a criterion for (i) boundedness, (ii) membership in the Cowen-Douglas class, (iii) unitary equivalence and similarity of these d-tuples. In particular, we show that the adjoint of the d-tuple of multiplication by the coordinate functions on the weighted Bergman spaces are in the Cowen-Douglas class B 1 (Ω). For an irreducible bounded symmetric domain Ω of rank 2, an explicit description of the operator d i=1 T * i T i is given. In general, based on this formula, we make a conjecture giving the form of this operator.