Spherical silica micro/nanomaterials with hierarchical structures: Synthesis and applications

Du, Xin; He, Junhui

doi:10.1039/c1nr10660k

Cited by 184 publications

(124 citation statements)

References 130 publications

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“…In the past few years, mesoporous nanomaterials have attracted more and more attention owing to their great potential application in many fields, such as physics, chemistry and textile, especially in biomedicine [1][2][3][4][5]. Mesoporous silica has been extensively explored as drug carriers due to their unique mesoporous structures and large surface area [6].…”

mentioning

confidence: 99%

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Liu

Tang

et al. 2012

Chin. Sci. Bull.

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Hollow mesoporous nanomaterial is a kind of promising new drug delivery system due to their unique hollow structures. In order to evaluate the toxicity of silica nanorattle (SN) particles in vivo, 40 female mice were used in this study to investigate the acute toxicity and oxidative damage. Mice were intravenously injected with SN suspension in sterile 5% glucose at 40, 80 and 240 mg/kg, respectively. The control group was administrated with equal-volume 5% glucose. Weight, feed intake, hematology analysis, blood biochemical assay and histopathology diagnosis were examined. The activities of SOD, GSH and CAT were measured as well. The results demonstrated that the levels of ALT and AST in the mice treated with 240 mg/kg SN increased significantly as compared with the control group (P<0.05), whereas the contents of BUN and CREA changed unremarkably. The activity of SOD induced by SN in the liver decreased significantly (P<0.05). In summary, this study revealed that liver was the target organ of the SN. It also can be concluded that activity of SOD played an important role in liver injury caused by SN. silica nanorattle, acute toxicity, oxidative stress, superoxide dismutase Citation:Fu C H, Liu T L, Tang F Q, et al. Acute toxicity and oxidative damage induced by silica nanorattle in vivo.

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mentioning

confidence: 99%

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Liu

Tang

et al. 2012

Chin. Sci. Bull.

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“…Recently, the shift toward developing hierarchical MSNs has led toward an influx of complex porous structures well documented by Du et al [209] To achieve the multi-level structures seen in hierarchical MSNs, typically additional co-templating agents are involved in conjunction to the primary pore determining agent. MSNs with hierarchical porous networks include those with several, homogeneous pore distributions or radially oriented pores, with a gradient of pore diameter.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Template-based syntheses for shape controlled nanostructures

Pérez-Page

et al. 2016

Advances in Colloid and Interface Science

132

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A variety of nanostructured materials are produced through template-based synthesis methods, including zerodimensional, one-dimensional, and two-dimensional structures. These span different forms such as nanoparticles, nanowires, nanotubes, nanoflakes, and nanosheets. Many physical characteristics of these materials such as the shape and size can be finely controlled through template selection and as a result, their properties as well. Reviewed here are several examples of these nanomaterials, with emphasis specifically on the templates and synthesis routes used to produce the final nanostructures. In the first section, the templates have been discussed while in the second section, their corresponding synthesis methods have been briefly reviewed, and lastly in the third section, applications of the materials themselves are highlighted. Some examples of the templates frequently encountered are organic structure directing agents, surfactants, polymers, carbon frameworks, colloidal sol-gels, inorganic frameworks, and nanoporous membranes. Synthesis methods that adopt these templates include emulsion-based routes and template-filling approaches, such as self-assembly, electrodeposition, electroless deposition, vapor deposition, and other methods including layer-by-layer and lithography. Templatebased synthesized nanomaterials are frequently encountered in select fields such as solar energy, thermoelectric materials, catalysis, biomedical applications, and magnetowetting of surfaces.

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“…This may be because of an interaction between the drug and carriers, and the adsorption on the surface of the amorphous silica nanoparticles, which have been extensively described in the literature. 39 Plasma concentration-time curve and relative bioavailability Under the analytical conditions, no endogenous peaks that interfered with TSIIA or loratadine (internal standard) were observed. In addition, the TSIIA peaks could be well distinguished from the loratadine peaks without any interference.…”

Section: Stability Testmentioning

confidence: 99%

“…36 The specific functional features of different types of silica can also be exploited to regulate the drug release rate. [37][38][39] Silica nanoparticles are amorphous in nature. The nanoparticles are small in size and have a large specific surface area, which improves drug dispersion in carriers, and significantly decreases the particle size of the drug, [40][41][42][43] possibly to the molecular level.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and in vivo evaluation of tanshinone IIA solid dispersions with silica nanoparticles

Jiang¹,

Zhang²,

Liu³

et al. 2013

IJN

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Abstract:We prepared solid dispersions (SDs) of tanshinone IIA (TSIIA) with silica nanoparticles, which function as dispersing carriers, using a spray-drying method and evaluated their in vitro dissolution and in vivo performance. The extent of TSIIA dissolution in the silica nanoparticles/TSIIA system (weight ratio, 5:1) was approximately 92% higher than that of the pure drug after 60 minutes. However, increasing the content of silica nanoparticles from 5:1 to 7:1 in this system did not significantly increase the rate or extent of TSIIA dissolution. The physicochemical properties of SDs were investigated using scanning electron microscopy, differential scanning calorimetry, X-ray powder diffraction, and Fourier transforms infrared spectroscopy. Studying the stability of the SDs of TSIIA revealed that the drug content of the formulation and dissolution behavior was unchanged under the applied storage conditions. In vivo tests showed that SDs of the silica nanoparticles/TSIIA had a significantly larger area under the concentration-time curve, which was 1.27 times more than that of TSIIA (P , 0.01). Additionally, the values of maximum plasma concentration and the time to reach maximum plasma concentration of the SDs were higher than those of TSIIA and the physical mixing system. Based on these results, we conclude that the silica nanoparticle based SDs achieved complete dissolution, increased absorption rate, maintained drug stability, and showed improved oral bioavailability compared to TSIIA alone.

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Spherical silica micro/nanomaterials with hierarchical structures: Synthesis and applications

Cited by 184 publications

References 130 publications

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Acute toxicity and oxidative damage induced by silica nanorattle in vivo

Template-based syntheses for shape controlled nanostructures

Preparation, characterization, and in vivo evaluation of tanshinone IIA solid dispersions with silica nanoparticles

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