Spherical MSU-1 Mesoporous Silica Particles Tuned for HPLC

Boissière, Cédric; Kummel, Mario; Persin, M.; Larbot, A.; Prouzet, Éric

doi:10.1002/1616-3028(200104)11:2<129::aid-adfm129>3.0.co;2-w

Cited by 131 publications

(41 citation statements)

References 11 publications

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“…Recently, several investigations have been reported in which nanostructured, mesoporous silicas were successfully applied in HPLC. [8,9] More than 60 % of all HPLC separations are carried out under reversed phase (RP) conditions. The surface modification of well defined silica beads with T-silyl functionalized organic systems [10] is the major route to creating phases for reversedphase liquid chromatography (RPLC).…”

Section: Introductionmentioning

confidence: 99%

New Inorganic-Organic Hybrid Materials for HPLC Separation Obtained by Direct Synthesis in the Presence of a Surfactant

et al. 2002

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Nanostructured, mesoporous inorganic–organic hybrid xerogels were reproducibly synthesized by a sol–gel procedure. For the introduction of long alkyl chains into inorganic polymers, trifunctional n‐alkyltrialkoxysilanes of the type CH3(CH2)nSi(OR)3 (n = 7, 11, 17; R = CH3, C2H5) were co‐condensed with Si(OEt)4 (TEOS). The synthetic pathway involves the employment of n‐hexadecylamine as template and catalyst. The xerogels obtained by the present procedure consist of uniform spherical particles with a diameter of about 1 μm. The composition of the new materials was determined by 13C and 29Si cross polarization magic angle spinning (CP/MAS) NMR spectroscopy. In addition, the degree of organization was investigated by small angle X‐ray and electron diffraction. In accordance with 13C CP/MAS NMR spectroscopic measurements, the alkyl chains form a crystalline arrangement within the silica polymer. Brunauer–Emmett–Teller (BET) adsorption measurements confirm specific surface areas of up to 1400 m2/g. The material properties prove the xerogels to be suitable as stationary phases in high‐performance liquid chromatography (HPLC). These novel mesoporous, nanostructured materials have been successfully employed in HPLC for the first time. Different standard reference materials (SRMs) containing polycyclic aromatic hydrocarbons have been separated with the xerogels described in the present work.

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Section: Introductionmentioning

confidence: 99%

New Inorganic-Organic Hybrid Materials for HPLC Separation Obtained by Direct Synthesis in the Presence of a Surfactant

et al. 2002

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“…But, currently, the most widely used column packing materials for high-performance liquid chromatography (HPLC) separation applications are based on 3-5 mm totally porous silica microspheres with a single pore-size distribution [8][9][10][11] and these packing materials have not high-sensitivity and high selectivity for HPLC analyses [12,13]. Synthesis of the silica particles with different surface characteristics as an ideal column packing materials for separation and analysis of complex mixtures have recently attract great interest considering their extremely high surface area to volume ratio [14,15]. In liquid chromatography, commercial silica packing materials usually exhibit lower surface area (\500 m 2 /g), which is provided by inter-particle porosity, and larger pore size distribution.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of the Coumarin-Containing Porous Silica as Column Packing Material

Kazmaz

Karataş

Köytepe

et al. 2015

J Inorg Organomet Polym

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For the synthesis of the coumarin based column packing materials, amino functionalized porous silica was prepared from the modification of silica with 3-aminopropyl triethoxysilane. This amino functional silica was reacted with 4-chloromethyl-7,8-dihydroxycoumarin. The produced silica based column packing material was characterized by spectral techniques, scanning electron microscope, X-ray diffraction analysis (X-ray), N 2 adsorption isotherms and thermal analysis techniques. The effect of coumarin group on the silica structure and separation properties as well as the thermal stability of materials was investigated. Average particle diameters, pore size and surface areas of the coumarin based silica particles were 2680 ± 750 lm, *33 nm and 118 ± 6 m 2 /g, respectively. 240 mm 9 4.6 mm high performance liquid chromatography column was packed with coumarin functionalized porous silica. Then, this column was applied to the separation of similar structure aromatic compounds such as benzene, toluene and xylene. Column performance was investigated by measuring time of continuous use peak asymmetry, resolution, and selectivity. Chromatographic resolutions of coumarin-modified packing material were in the range of 2.28-2.35. According to these data, for the separation of aromatic compounds, while pure silica does not provide effective separation, coumarin based column packing material has showed good separation and selectivity.

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“…Since the discovery of MCM-41 in 1999 [1], ordered mesoporous silicas (OMSs) have attracted significant attention in the fields of adsorption and separation [2][3][4]. In comparison with the traditionally commercial silicas, the OMSs exhibit unique properties such as large surface area, narrow pore size distribution and adjustable pore diameter.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Ordered Mesoporous Silica Spheres Using Anionic and Nonionic Mixed Surfactants for Their Potential Application in LC

Wu¹,

Di²,

Liu³

et al. 2011

Chromatographia

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Ordered mesoporous silicas (OMSs) with spherical morphology were synthesized by using mixed surfactants of anionic sodium dodecyl sulfate and nonionic block copolymer EO 20 PO 70 EO 20 (P123) as template through an acid-catalyzed silica sol-gel process. A variety of characterizations demonstrated that the silica products exhibited well-formed spherical morphology, ordered mesostructure, narrow pore size distribution and large surface area (*700 m 2 g -1 ). It was found that the synthesized OMSs had high adsorption capacity by using oxymatrine as model solute. The column packed with the silica spheres exhibited low back pressure and baseline separation of aromatic compounds such as benzene and nitrobenzene could be achieved. These results demonstrated the synthesized OMSs as a potential stationary phase for liquid chromatography.

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Spherical MSU-1 Mesoporous Silica Particles Tuned for HPLC

Cited by 131 publications

References 11 publications

New Inorganic-Organic Hybrid Materials for HPLC Separation Obtained by Direct Synthesis in the Presence of a Surfactant

New Inorganic-Organic Hybrid Materials for HPLC Separation Obtained by Direct Synthesis in the Presence of a Surfactant

Synthesis of the Coumarin-Containing Porous Silica as Column Packing Material

Synthesis and Characterization of Ordered Mesoporous Silica Spheres Using Anionic and Nonionic Mixed Surfactants for Their Potential Application in LC

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