Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan

In vitro release and in vitro–in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles

“…32 The average pore diameter of the empty HMSNs was 2.74 nm and the pore size was uniformly distributed within a relatively narrow range, between 1 nm and 6 nm. The empty HMSNs with an ultranarrow pore size (2.74 nm on average) prepared in this work were obviously smaller than that of the porous silica nanoparticles reported by Zhang et al 3 When loaded with drug, HMSNs showed no hysteresis loop, suggesting that most pores within the HMSNs were completely filled with drug. These results are in agreement with the transmission electron microscopic image in Figure 1 The drug-loading rate of the silybin meglumine-loaded HMSNs was 58.91% ± 0.39%, while the drug-loading rate of silybin meglumine-loaded solid silica nanoparticles was only 5.78% ± 0.12%.…”

“…1,2 Mesoporous silica nanoparticles have attracted considerable attention due to their ability to enhance solubility of poorly water-soluble drugs, as well as to achieve sustained drug release, leading to improved bioavailability. 3,4 Advantages of mesoporous silica nanoparticles, such as large surface area, high pore volume, tunable pore size, and well defined pore structure, as well as mechanical and chemical stability and protection of the integrity of the molecular structure of the drug, 5-7 make them ideal for controlled drug delivery systems. Most recently, mesoporous silica nanoparticles were developed for intracellular controlled drug/gene delivery 8,9 and targeted drug delivery to cancer cells.…”

“…3,5 However, the in vitro sustained-release duration of these formulations lasted no longer than 24 hours. Therefore, it is desirable to develop a drug-release model that can achieve in vitro sustained release for a long period of time.…”

Targeted delivery of mesoporous silica nanoparticles loaded monastrol into cancer cells: an in vitro study

“…Several drugs with low water solubility have been explored to demonstrate this concept including ibuprofen, rifampin, etc. (Zhang et al 2010;Mohseni et al 2015;Ganesh and Lee 2013). Based on non-toxicity and biocompatibility, silica nanoparticles are proposed as alternative carriers for drug delivery as these can be degraded into its simple silanol units and can be removed from the body (Fent et al 2010;Yu et al 2009;Liu et al 2011).…”

Fabrication of Janus particles composed of poly (lactic-co-glycolic) acid and hard fat using a solvent evaporation method

“…Microparticles have been widely used in pharmaceutical formulations including as carriers for oral (1)(2)(3)(4)(5) and pulmonary drug delivery (6) or injectable formulations for long-term drug release (7). Developing microparticles as oral drug carriers to improve drug absorption in the gastrointestinal (GI) tract is an attractive challenge in the pharmaceutical field and a current focus.…”