Spherical composite particles of rice starch and microcrystalline cellulose: A new coprocessed excipient for direct compression

Abstract

KEYWORDS: rice starch, microcrystalline cellulose, spray drying, coprocessed excipient, direct compression Composite particles of rice starch (RS) and microcrystalline cellulose were fabricated by spray-drying technique to be used as a directly compressible excipient. Two size fractions of microcrystalline cellulose, sieved (MCS) and jet milled (MCJ), having volumetric mean diameter (D 50 ) of 13.61 and 40.51 µm, respectively, were used to form composite particles with RS in various mixing ratios. The composite particles produced were evaluated for their powder and compression properties. Although an increase in the microcrystalline cellulose proportion imparted greater compressibility of the composite particles, the shape of the particles was typically less spherical with rougher surface resulting in a decrease in the degree of flowability. Compressibility of composite particles made from different size fractions of microcrystalline cellulose was not different; however, using MCJ, which had a particle size range close to the size of RS (D 50 = 13.57 µm), provided more spherical particles than using MCS. Spherical composite particles between RS and MCJ in the ratio of 7:3 (RS-MCJ-73) were then evaluated for powder properties and compressibility in comparison with some marketed directly compressible diluents. Compressibility of RS-MCJ-73 was greater than commercial spray-dried RS (Eratab), coprocessed lactose and microcrystalline cellulose (Cellactose), and agglomerated lactose (Tablettose), but, as expected, lower than microcrystalline cellulose (Vivapur 101). Flowability index of RS-MCJ-73 appeared to be slightly lower than Eratab but higher than Vivapur 101, Cellactose, and Tablettose. Tablets of RS-MCJ-73 exhibited low friability and good self-disintegrating property. It was concluded that these developed composite particles could be introduced as a new coprocessed direct compression excipient.

Hypolipidemic applications of microcrystalline cellulose composite synthesized from different agricultural residues

“…The starch may be obtained from either the grain of corn, rice, or wheat, or from potato. Starches from different botanical sources do not have identical properties with respect to their uses as additives in tablet formulations [13].…”

A Review on Co-Processed Excipients: Current and Future Trend of Excipient Technology

“…Composite particles of rice starch and MCC were fabricated by spray-drying technique to be used as a directly compressible excipient. The compressibility was greater than commercial spray-dried rice starch (Eratab), coprocessed lactose and microcrystalline cellulose (Cellactose), and agglomerated lactose (Tablettose), but, lower than microcrystalline cellulose (Vivapur 101) [36].…”

“…There are many methods which can be used for co-processing such as wet granulation, melt granulation, freeze drying, spray drying, hot melt extrusion [36][37][38][39]. A comprehensive detail has been provided later in this review.…”

Untitled

“…25 Spray drying of rice starch with jet-milled MCC (with volumetric mean diameter of 13.57 mm) in the proportion of 7:3 resulted in spherical composites of a directly compressible excipient with high compressibility, good flowability, and self disintegration 26 .…”