Sphere-forming corneal cells repopulate dystrophic keratoconic stroma: Implications for potential therapy

Wadhwa, Himanshu; Ismail, Salim; McGhee, Jennifer Jane; Werf, Bert van der; Sherwin, Trevor

doi:10.4252/wjsc.v12.i1.35

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…27 After implanting into a dystrophic keratoconic corneal tissue, CSSCs exhibited migratory stromal cell phenotypes and repopulated the keratoconic stroma. 28 The in vivo injection of CSSCs into the cornea stroma of lumican knockout mice demonstrated expression of lumican and restored collagen fibril defects and corneal transparency. 29 Currently, a clinical study (early phase 1) using CSSCs is under way, 30 with the hope of curing corneal scars and opacities.…”

Section: Corneal Stromamentioning

confidence: 99%

“…CSSCs have also gained interest because of their anti‐inflammatory and immune‐modulating properties, suggesting that CSSCs have a promising potential in corneal regeneration 27 . After implanting into a dystrophic keratoconic corneal tissue, CSSCs exhibited migratory stromal cell phenotypes and repopulated the keratoconic stroma 28 . The in vivo injection of CSSCs into the cornea stroma of lumican knockout mice demonstrated expression of lumican and restored collagen fibril defects and corneal transparency 29 .…”

Section: Stem Cells In the Anterior Segmentmentioning

confidence: 99%

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Adult stem cells in the eye: Identification, characterisation, and therapeutic application in ocular regeneration – A review

Xiao,

McGhee,

Zhang

2024

Clinical Exper Ophthalmology

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Adult stem cells, present in various parts of the human body, are undifferentiated cells that can proliferate and differentiate to replace dying cells within tissues. Stem cells have specifically been identified in the cornea, trabecular meshwork, crystalline lens, iris, ciliary body, retina, choroid, sclera, conjunctiva, eyelid, lacrimal gland, and orbital fat. The identification of ocular stem cells broadens the potential therapeutic strategies for untreatable eye diseases. Currently, stem cell transplantation for corneal and conjunctival diseases remains the most common stem cell‐based therapy in ocular clinical management. Lens epithelial stem cells have been applied in the treatment of paediatric cataracts. Several early‐phase clinical trials for corneal and retinal regeneration using ocular stem cells are also underway. Extensive preclinical studies using ocular stem cells have been conducted, showing encouraging outcomes. Ocular stem cells currently demonstrate great promise in potential treatments of eye diseases. In this review, we focus on the identification, characterisation, and therapeutic application of adult stem cells in the eye.

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Section: Corneal Stromamentioning

confidence: 99%