“…Modified sphenopalatine ganglion block 4,8 Sphenopalatine block with lidocaine spray 6 Intranasal lidocaine atomization 5 Epidural blood patch [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] Synacthen depot 15 Tetracosactin 16 In a reduced volume of the CSF, in the case of fistula with loss of CSF, the pain is caused by the exit of the CSF from the intracranial space into the spinal dural sac. In order to keep the intracranial volume constant with the three mentioned compartments (i.e., brain parenchyma, CSF, and blood), there is vasodilation, mainly of the venous sinuses and large veins, as these vessels are quite innervated, the individual feels an intense headache when raising the head in relation to the trunk.…”