Spheno-Orbital Meningiomas: An Analysis Based on World Health Organization Classification and Ki-67 Proliferative Index

Belinsky, Irina; Murchison, Ann P.; Evans, James J.; Andrews, David W.; Farrell, Christopher; Casey, James; Curtis, Mark; Choi, Kamila A. Nowak; Werner‐Wasik, Maria; Bilyk, Jurij R.

doi:10.1097/iop.0000000000000904

Cited by 16 publications

(10 citation statements)

References 44 publications

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“…In our cohort, the overall total recurrence rate was 34.9%, which was in accordance with the previous reports in the literature (7-46.4%) (4)(5)(6)(37)(38)(39). The most concerning prognostic factors included the EOR, the histological grade, and adjuvant radiotherapy after surgery.…”

Section: Prognosissupporting

confidence: 91%

“…Histological grades were also significantly related to DFS by multivariate analysis (P = 0.007). Besides WHO grades, the Ki-67 index is a valuable marker to predict meningioma recurrence, especially in histologically borderline meningiomas and possibly to identify the type of low grade of meningiomas at risk of recurrence (4,38). Besides, the insufficiency of PRs is associated with prognosis and is an important factor in recurrence and survival (41).…”

Section: Prognosismentioning

confidence: 99%

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Management of Skull-Base Meningiomas With Extracranial Extensions: Clinical Features, Radiological Findings, Surgical Strategies, and Long-Term Outcomes

Li²,

Jie³

et al. 2022

Front. Neurol.

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Objectives:The aim of this research was to summarize the clinical and prognostic features of the skull-base meningiomas with extracranial extensions, and enhance the management of skull-base communicative meningiomas.MethodsWe retrospectively studied the medical records and analyzed the follow-up information of 53 patients who have done surgery for skull-base meningiomas with extracranial extensions in West China Hospital of Sichuan University from 2009 to 2020.ResultsThe incidence of skull-base meningiomas with extracranial extensions was 0.74%. The average diagnosis age was 45.9 years, with a 1:3.1 men to women ratio. WHO grade I was seen in 84.9% of patients, and higher grades were found in 15.1%. Heterogeneous enhancement, high bone invasion rate, high incidence of peritumoral edema, and high dural tail sign rate were typical imaging features. Routine craniotomy and endoscopic endonasal approach were adopted, and gross total resection was performed in 62.3% of cases with 20.8% postoperative complication rates. The average follow-up time was 61.5 months, with a recurrence rate of 34.9%. By survival analysis, the extent of resection (p = 0.009) and the histological grade (p = 0.007) were significantly related to the prognosis. Adjuvant radiotherapy proved beneficial in patients with subtotal resection (p = 0.010) and high-grade meningiomas (p = 0.018).ConclusionsSkull-base meningiomas with extracranial extensions were sporadic. According to the tumor location and communication way showed by the preoperative imaging, routine craniotomy or endoscopic endonasal approach with a reasonable skull-base repair strategy could be adopted to achieve the maximum tumor resection. Maximized resection, adjuvant radiotherapy, and low histological grade indicate a better prognosis.

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Section: Prognosissupporting

confidence: 91%

Section: Prognosismentioning

confidence: 99%

Management of Skull-Base Meningiomas With Extracranial Extensions: Clinical Features, Radiological Findings, Surgical Strategies, and Long-Term Outcomes

Li²,

Jie³

et al. 2022

Front. Neurol.

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“…In the literature review, we found 83 publications between 2010 and 2019, among which 24 series of spheno-orbital meningiomas, and we excluded 7 series because they lacked some relevant data [10][11][12][13][14][15][16] .…”

Section: Resultsmentioning

confidence: 99%

Female gender and exogenous progesterone exposition as risk factors for spheno-orbital meningiomas

et al. 2020

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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“…In our cohort, we observed a total of 10 patients with postoperative hypoesthesia in the region of the trigeminal nerve, which was significantly (p=0.0107) associated with GTR (Table 3). Other groups observed only sporadic trigeminal nerve deficits and other cranial nerve deficits (5,8,12,14,19,(24)(25)(26). This could be biased by the surgical experience of the surgeon and the aggression of the tumors.…”

Section: Functional Outcomementioning

confidence: 99%

Progression-Free Survival, Prognostic Factors, and Surgical Outcome of Spheno-Orbital Meningiomas

et al. 2021

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ObjectiveSpheno-orbital meningiomas (SOM) are rare intracranial tumors that arise at the sphenoid wing. These tumors can invade important neurovascular structures making radical resection difficult, while residual tumors often lead to recurrence. The purpose of this study was to evaluate prognostic factors influencing the recurrence and progression-free survival (PFS) rates of spheno-orbital meningiomas, with a particular focus on the role of surgery and postoperative radiotherapy.MethodsBetween 2000 and March 2020, 65 cases of spheno-orbital meningioma were included, of which 50 cases underwent surgical treatment alone, and 15 cases underwent resection and radiotherapy. A Kaplan-Meier analysis was performed to provide median point estimates and PFS rates; further, Cox regression analysis was used to identify significant factors associated with treatment.ResultsGross total resection significantly reduced the risk of recurrence (p-value = 0.0062). There was no significant benefit for progression-free survival after postoperative radiotherapy (p-value = 0.42). Additionally, spheno-orbital meningiomas with an invasion of the cavernous sinus and intraconal invasion showed significantly worse PFS compared to other locations (p-value = 0.017).ConclusionThe maximal safe resection remains the most important prognostic factor associated with lower recurrence rates and longer PFS in patients with spheno-orbital meningioma. The invasion of the cavernous sinus and intraconal invasion was an independent factor associated with worse PFS. Patients with postoperative high-precision radiotherapy did not show significantly better PFS due to the small number of patients.

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Spheno-Orbital Meningiomas: An Analysis Based on World Health Organization Classification and Ki-67 Proliferative Index

Cited by 16 publications

References 44 publications

Management of Skull-Base Meningiomas With Extracranial Extensions: Clinical Features, Radiological Findings, Surgical Strategies, and Long-Term Outcomes

Management of Skull-Base Meningiomas With Extracranial Extensions: Clinical Features, Radiological Findings, Surgical Strategies, and Long-Term Outcomes

Female gender and exogenous progesterone exposition as risk factors for spheno-orbital meningiomas

Progression-Free Survival, Prognostic Factors, and Surgical Outcome of Spheno-Orbital Meningiomas

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