Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge <i>Spheciospongia</i> sp.

Whitson, Emily L.; Bugni, Tim S.; Chockalingam, Priya; Concepción, Gisela P.; Harper, Mary Kay; He, Min; Hooper, John N. A.; Mangalindan, Gina C.; Ritacco, Frank V.; Ireland, Chris M.

doi:10.1021/np8001628

Cited by 34 publications

(41 citation statements)

References 32 publications

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“…The spheciosterol sulfates A-C, isolated from a Spheciospongia sp., were recently shown to inhibit PKCζ and NF-κB activation 6. It was shown that the sterol side chain factors into their PKCζ activity; the longer side chain seen in spheciosterol sulfate C is 5-fold more active than spheciosterol sulfate B, and 10-fold more active than the shorter side chains seen in spheciosterol sulfate A and topsentiasterol sulfate E 6.…”

Section: Resultsmentioning

confidence: 99%

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Fibrosterol Sulfates from the Philippine SpongeLissodendoryx(Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Whitson¹,

Bugni²,

Chockalingam³

et al. 2009

J. Org. Chem.

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Section: Resultsmentioning

confidence: 99%

“…In addition, the spheciosterol sulfates A–C, isolated from a Spheciospongia sp. sponge, were recently shown to inhibit protein kinase C ζ (PKCζ), as well as downstream NF-κB activation 6. PKCζ has been implicated as an integral factor in several types of cancer,7–11 obesity,12 and osteoarthritis 8,13.…”

Section: Introductionmentioning

confidence: 99%

Fibrosterol Sulfates from the Philippine SpongeLissodendoryx(Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Whitson¹,

Bugni²,

Chockalingam³

et al. 2009

J. Org. Chem.

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“…81 However, due to the unclear role of PKC-zeta in VSMC growth, the efficacy of PKC-zeta inhibitor in restenosis is uncertain at present.…”

Section: Pkc Inhibitor and Restenosis Preventionmentioning

confidence: 99%

Therapeutic Potential for Protein Kinase C Inhibitor in Vascular Restenosis

Ding

Tsao

Chai

et al. 2010

J Cardiovasc Pharmacol Ther

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Vascular restenosis, an overreaction of biological response to injury, is initialized by thrombosis and inflammation. This response is characterized by increased smooth muscle cell migration and proliferation. Available pharmacological treatments include anticoagulants, antiplatelet agents, immunosuppressants and antiproliferation agents. Protein kinase C (PKC), a large family of serine/threonine kinases, has been shown to participate in various pathological stages of restenosis. Consequently, PKC inhibitors are expected to exert a wide range of pharmacological activities therapeutically beneficial for restenosis. In this review, the roles of PKC isozymes in platelets, leukocytes, endothelial cells and smooth muscle cells are discussed, with emphasis given to smooth muscle cells. We will describe cellular and animal studies assessing prevention of restenosis with PKC inhibitors, particularly targeting -alpha, -beta, -delta and -zeta isozymes. The delivery strategy, efficacy and safety of such PKC regulators will also be discussed.

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“…Steroidal compounds as well as phthalate derivatives have been isolated from Spheciospongia sp. (Safaeian et al, 2009;Ma et al, 2004;Whitson et al, 2008). The increasing threat of cancer has initiated a renewal of interest in the search for novel anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic ceramides from the Red Sea sponge Spheciospongia vagabunda

et al. 2015

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Extracts of Egyptian marine organisms from the Red Sea were screened for their anticancer activity using sulforhodamine B assay. The extract of the Red Sea sponge Spheciospongia vagabunda possessed promising anticancer activity against HepG2 (liver cancer cell line) and MCF-7 (breast cancer cell line). Isolation of three new ceramides: N-[(2S,3S,4R)-1,3,4-trihydroxytetradecan-2-yl] tridecanamide (1), (R)-2 0 -hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxypentacosan-2-yl] octadecanamide (2) and (R,Z)-2 0 -hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxytricosan-2-yl) nonadec-10-enamide (3) was accomplished via bioassay-guided fractionation. Structure elucidation was achieved using spectroscopic techniques, including 1D and 2D NMR and HRMS. Compounds 2 and 3 displayed high potential cytotoxicity against HepG2 (IC 50 24.7 and 21.3 lM, respectively) and MCF-7 (IC 50 26.8 and 29.8 lM, respectively), compared with doxorubicin as control drug.

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Spheciosterol Sulfates, PKCζ Inhibitors from a Philippine Sponge Spheciospongia sp.

Cited by 34 publications

References 32 publications

Fibrosterol Sulfates from the Philippine SpongeLissodendoryx(Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Fibrosterol Sulfates from the Philippine SpongeLissodendoryx(Acanthodoryx) fibrosa: Sterol Dimers that Inhibit PKCζ

Therapeutic Potential for Protein Kinase C Inhibitor in Vascular Restenosis

Cytotoxic ceramides from the Red Sea sponge Spheciospongia vagabunda

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