Sphaeranthus senegalensis DC: Evaluation of chemical constituents, oral safety, gastroprotective activity, and mechanism of action of its hydroethanolic extract

Sudi, İsmaila Yada; Ahmed, Mansoor; Adzu, Bulus

doi:10.1016/j.jep.2020.113597

Cited by 7 publications

(5 citation statements)

References 57 publications

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“…This is the first time we are reporting the lignoids (lariciresinol derivatives), and flavonoid glycosides (kaempferol and tricin derivatives) from this medicinal plant. Although, the gastro‐protective effects of some lignoids, including lariciresinol, against acute gastric ulcer models have been demonstrated by some authors, to the best of our knowledge, the gastric ulcer healing effects of kaempferol, tricin and lariciresinol are yet to be tested in any animal model [18,19] . It is probable that the gastric ulcer healing effects of HEHs might be due in part to some of these pharmacologically active phytochemical substances tentatively identified in HEHs.…”

Section: Resultsmentioning

confidence: 99%

“…Although, the gastroprotective effects of some lignoids, including lariciresinol, against acute gastric ulcer models have been demonstrated by some authors, to the best of our knowledge, the gastric ulcer healing effects of kaempferol, tricin and lariciresinol are yet to be tested in any animal model. [18,19] It is probable that the gastric ulcer healing effects of HEHs might be due in part to some of these pharmacologically active phytochemical substances tentatively identified in HEHs. We suggest that the effects of these identified compounds in the chronic ulcer healing effects be evaluated in the future using both in vitro and in vivo studies.…”

Section: Introductionmentioning

confidence: 99%

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Evidence for the Involvement of Cytokines Modulation and Prokinetic Properties in Gastric Ulcer Healing Effects of Helicteres sacarolha A. St.‐Hil. A. Juss.

Balogun

Damazo

Pavan

et al. 2022

Chemistry & Biodiversity

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Preparations of Helicteres sacarolha (Malvaceae) leaves and roots are used in the form of decoction, infusion or maceration, to treat gastrointestinal disturbances, among others. Studies supporting some of its ethnomedicinal uses are still incipient. The present study aimed to investigate it potential effect on chronic ulcer, ulcerative colitis and possible prokinetic activities as part of its mechanism of action. The powdered leaves of Helicteres sacarolha (HEHs) was prepared by maceration in 70 % hydroethanolic solution. Its qualitative phytochemical constituents were investigated by direct flow injection analysis coupled to atmospheric pressure chemical ionization ion trap tandem mass spectrometry (FIA‐APCI‐IT‐MSn). The gastric ulcer healing effect was evaluated in acetic acid induced chronic ulcer in mice and the lesions were evaluated, including analysis of blood plasma cytokine levels. The prokinetic properties (gastric emptying and intestinal transit) were carried out in mice. Potential anti‐ulcerative colitis activity was evaluated in rats using 2,4,6‐trinitrobenzenesulfonic acid (5 % TNBS) ‐induced colitis. All animal experiments were carried out at the doses of 20, 50 and 250 mg/kg (p.o.). Eight compounds were putatively identified, specifically lariciresinol, and its derivatives, kaempferol derivatives and Tricin‐O‐Glc. The extract promoted increased gastric ulcer healing at all doses tested. Modulation of the cytokines involved inhibition of some key pro‐inflammatory cytokines with maximum effect on IL‐1β (70 %, 50 mg/kg, p<0.05), TNF‐α (79 %, 20 mg/kg, p<0.01), and in the anti‐inflammatory cytokines, namely IL‐10 (57 %, 50 mg/kg, p<0.05) and IL‐17 (79 %, only at 50 mg/kg, p<0.05). Histological findings demonstrated a mitigated inflammatory activity, and tissues undergoing regeneration. HEHs treatment caused delayed gastric emptying, and increased intestinal transit, but had no effect in the experimentally induced ulcerative colitis. We report for the first time putatively the presence of Lariciresinol and tricin derivatives from the hydroethanolic leaves extract of H. sacarolha. Its possible mechanism of actions of gastric ulcer healing involves cytokines modulation, mitigation of inflammatory response and tissue regeneration and provoked opposing effect in the gastrointestinal system. The present study demonstrates the therapeutic potential of H. sacarolha leaves used in Brazilian ethnomedicine in the treatment of chronic gastric ulcer.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evidence for the Involvement of Cytokines Modulation and Prokinetic Properties in Gastric Ulcer Healing Effects of Helicteres sacarolha A. St.‐Hil. A. Juss.

Balogun

Damazo

Pavan

et al. 2022

Chemistry & Biodiversity

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“…Thus, chlorogenic acid may be a natural substance that can be used to prevent and cure gastric ulcers caused by a variety of factors (Almeida et al., 2019). In addition, several researchers have claimed that rutin functions as an inhibitor of proinflammatory cytokines and neutrophil infiltration and that it is an enhancer of antioxidant enzyme activity (Arunachalam et al., 2019; Sudi et al., 2021). Rutin potentially reduces the effect of oxidative stress and inflammation on the gastric mucosa and prevents the initiation of mucosal ulcers in a variety of gastric ulcer models (Garro et al., 2015; Ibrahim et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of active components of Eucommia ulmoides leaves on gastric ulcers in rats: Involvement of the PI3K/Akt/NF‐κB pathway

Gong

Guo

et al. 2022

Journal of Food Science

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Eucommia ulmoides leaves are widely developed as food and medicines in China and Japan. Its main components have anti-inflammatory properties against gastric ulcers. The purpose of this study was to assess the protective role of an extract derived from the active components of Eucommia ulmoides leaves (EUL 50) against a gastric ulcer and analyze the underlying antiulcer mechanism. The main components of EUL 50 were identified using an ultra-performance liquid chromatography (UPLC) method. Network pharmacology and molecular docking were performed to predict the possible mechanism of action of EUL 50 in the treatment of gastric ulcers. The rats received EUL 50 intragastric administration twice a day for 3 days. Hydrochloric acid/ethanol (HCl/EtOH) was utilized to induce gastric ulcers, followed by histopathological and histochemical evaluation of the ulcer tissues and determination of the main oxidative stress parameters and inflammatory cytokines. The expression of PI3K/Akt/NF-κB pathway-related proteins was measured. Neochlorogenic acid, chlorogenic acid, rutin, and so on were identified as the major components of EUL 50 by UPLC. The prediction results identified the PI3K/Akt/NF-κB signaling pathway as the main possible protective mechanism against gastric ulcers. Furthermore, in a dose-dependent manner, EUL 50 reduced gastric tissue damage. In addition, the high dose of EUL 50 administration resulted in remarkable reductions in the levels of malondialdehyde (MDA), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and interleukin-1β (IL-1β) by 22.64%, 42.61%, 57.78%, and 56.51%, respectively, and suppression of the phosphorylation of Akt, p65, IKKα, and IκBα by 60.87%, 67.65, 74.58%, and 59.57%, respectively, and increased the antioxidant enzyme activity. EUL 50 is rich in flavonoids and organic acids that can act on the PI3K/Akt/NF-κB signaling pathway; as a result, oxidative stress and inflammation are considerably reduced, and gastric ulcers caused by HCl/EtOH are reduced.

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“…Therefore, more effective and less toxic therapies are needed for GU treatment. Both clinical and experimental studies have demonstrated that herbal medicines exert protective effects against GU with fewer side effects and lower medical expenses ( Devanesan et al, 2018 ; Zhang et al, 2018 ; Sudi et al, 2020 ). Traditional Chinese Medicine (TCM) has been widely used in China for maintaining health and treating diseases for several years.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Potential of Sarcandra glabra (Thunb.) Nakai. in Treating Ethanol-Induced Gastric Ulcer in Rats Based on Metabolomics and Network Analysis

Wen

Liu

et al. 2022

Front. Pharmacol.

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Gastric ulcer (GU) is one of the most commonly diagnosed diseases worldwide, threatening human health and seriously affecting quality of life. Reports have shown that the Chinese herbal medicine Sarcandra glabra (Thunb.) Nakai (SGN) can treat GU. However, its pharmacological effects deserve further validation; in addition, its mechanism of action is unclear. An acute gastric ulcer (AGU) rat model induced by alcohol was used to evaluate the gastroprotective effect of SGN by analysis of the histopathological changes in stomach tissue and related cytokine levels; the potential mechanisms of action of SGN were investigated via serum metabolomics and network pharmacology. Differential metabolites of rat serum were identified by metabolomics and the metabolic pathways of the identified metabolites were enriched via MetaboAnalyst. Furthermore, the critical ingredients and candidate targets of SGN anti-AGU were elucidated. A compound-reaction-enzyme-gene network was established using Cytoscape version 3.8.2 based on integrated analysis of metabolomics and network pharmacology. Finally, molecular docking was applied to verify the acquired key targets. The results showed that SGN exerted a certain gastroprotective effect via multiple pathways and targets. The effects of SGN were mainly caused by the key active ingredients isofraxidin, rosmarinic, and caffeic acid, which regulate hub targets, such as PTGS2, MAPK1, and KDR, which maintain the homeostasis of related metabolites. Signal pathways involved energy metabolism as well as immune and amino acid metabolism. Overall, the multi-omics techniques were proven to be promising tools in illuminating the mechanism of action of SGN in protecting against diseases. This integrated strategy provides a basis for further research and clinical application of SGN.

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Sphaeranthus senegalensis DC: Evaluation of chemical constituents, oral safety, gastroprotective activity, and mechanism of action of its hydroethanolic extract

Cited by 7 publications

References 57 publications

Evidence for the Involvement of Cytokines Modulation and Prokinetic Properties in Gastric Ulcer Healing Effects of Helicteres sacarolha A. St.‐Hil. A. Juss.

Evidence for the Involvement of Cytokines Modulation and Prokinetic Properties in Gastric Ulcer Healing Effects of Helicteres sacarolha A. St.‐Hil. A. Juss.

Protective effect of active components of Eucommia ulmoides leaves on gastric ulcers in rats: Involvement of the PI3K/Akt/NF‐κB pathway

Assessment of the Potential of Sarcandra glabra (Thunb.) Nakai. in Treating Ethanol-Induced Gastric Ulcer in Rats Based on Metabolomics and Network Analysis

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