Spezielle pathologische Anatomie II

Doerr, Wilhelm

doi:10.1007/978-3-662-38561-6

Cited by 6 publications

(6 citation statements)

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“…This is in agreement with the observation that pancreatic cancer has the highest rate of hematogenous metastases compared to gastric and colorectal malignancies (Doerr et al, 1973).…”

Section: Discussionsupporting

confidence: 88%

“…The hypothesis that such stained cells are most probably circulating tumor cells is supported by our results since these cells express tumor-associated antigens as well as cytokeratin. From a clinical point of view, it appears to be important to examine the peritoneal cavity for seeded tumor cells, where gastric, colorectal and pancreatic cancers frequently relapse and metastasize (Doerr et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

“…In gastric, colorectal and pancreatic cancers, bone marrow metastases are a rare event (Doerr et al, 1973).…”

mentioning

confidence: 99%

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Immunocytological detection of micrometastatic cells: Comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients

Juhl

Stritzel

Wroblewski

et al. 1994

Intl Journal of Cancer

167

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The prognosis of digestive cancers is poor mainly due to intraperitoneal relapse by cells which may have already been seeded at the time of surgery. Using immunocytology we investigated the peritoneal cavity and, as a comparison, the bone marrow of 147 patients with gastric, colorectal and pancreatic cancer for micrometastatic cells. Cytological samples from peritoneal cavity lavages and bone marrow aspirates were analyzed using monoclonal antibodies (MAbs) against tumor-associated antigens (TAA) (CEA, CA-19-9, 17-1-A, C-54-0, Ra96) and compared to a MAb staining cytokeratins (KL-1). Patients with benign diseases served as controls. Intraperitoneal micrometastatic cells were detected in 27% of colorectal, 43% of gastric and 58% of pancreatic cancer patients. In the bone marrow, the corresponding data were 29% for colorectal, 25% for gastric and 58% for pancreatic cancer patients. Combined evaluation of both compartments increased the detection rate significantly (colorectal cancer: 40%, gastric cancer: 52%, pancreatic cancer: 72%). No unwarranted reactions were found in the control group. Combining 3 antibodies (CA-19-9, Ra96, C-54-0) enabled good detection for peritoneal cavity samples. In the bone marrow, the use of 2 antibodies (KL-1 and CA-19-9) detected 94% of all positive samples, whereas KL-1 and CA-19-9 stained approx. 70% of all positive samples in each case. The occurrence of stained cells in the peritoneal cavity correlated with classical prognostic factors (TNM classification).

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“…This is in agreement with the observation that pancreatic cancer has the highest rate of hematogenous metastases compared to gastric and colorectal malignancies (Doerr et al, 1973).…”

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Immunocytological detection of micrometastatic cells: Comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients

Juhl

Stritzel

Wroblewski

et al. 1994

Intl Journal of Cancer

167

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“…Zu diesem Komplex liegen detaillierte und differenzierte Untersuchungen, besonders von Henn und Spann (1965) sowie Spann und Henn (1970) vor, auf welche hier nut verwiesen werden kann (hier weitere Literatur). Auf diesbeztigliche ausftthrliche Literatur yon Wegener und Sack (1967) Untersuchungen fast ausschlieNich der mechanischen Wirkung gewidmet war: Zahlreiche Untersucher stellten mit morphometrischen Methoden den Grad der Gefagverschltisse fest und kamen zu dem Schluf~, dat~ eine LFE nur dann als causa morris gelten k6nne, wenn sie: 1/3 aller Gefal~e (Falzi et al 1964), 1/2 aller Gef~it~e (M6fl und Heller 1971), 3/4 aller Gefiige (Doerr et al 1971), mehr als 2/3 aller Gefat~e (Schmidt 1929) einnimmt. Die vorliegende Untersuchung soll sich im wesentlichen konzentrieren auf die pulmonale FE.…”

Section: Diskussionunclassified

Die Fettembolie der Lungen als Todesursache. Ätiologie, Pathogenese und Beweisführung

Brinkmann

Borgner

1976

Z Rechtsmed

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A comprehensive survey is given of the most important theories of etiology, pathogenesis and pathophysiology of pulmonary fat embolism. Autopsy and microscopic examinations were performed on 26 corpses with different causes of death. The total contents of fat of the lungs was analyzed by chloroform extraction. Death due to pulmonary fat embolism was diagnosed in three cases. In those with whole fat contents of about 20 g or more the histological degree was equivalent to occlusion of half of all vessels. The histological feature resembled that of shock; hemorrhage and microthrombosis were regular findings. The functional and morphological relationships with shock are discussed. It is concluded that, at least in the initial stage, fat embolism is due to mechanical injury. This mechanism is possibly altered or enhanced by biochemical changes in later phases. Pulmonary fat embolism is a disease which may cause death if mechanical, toxic and shock-inducing effects lead to insufficiency of the cardio-respiratory system. In forensic cases death due to fat embolism should be diagnosed only after exclusion of other lethal factors. Posttraumatic cases often show competition with shock due to hemorrhage. It is important to relate the degree of fat embolism to preexisting diseases.

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“…Als Ursachen hierfiir werden neben dem Darminhalt und verschluckter Luft, die von den proximalen Darmabschnitten weitertransportiert werden, die fortbestehende Sekretion sowie die Gasbildung aus fermentativen Prozessen des gestauten Darminhaltes diskutiert [3]. 10 Ix aufweist und die darunter liegende Muskulatur capill/ir gef/iBversorgt ist [1]. Anoxie aufgefaBt worden.…”

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Die Sauerstoffversorgung des menschlichen D�nndarmes im mechanischen Ileus

Thermann¹,

Jostarndt²,

Eberhard³

et al. 1985

Langenbecks Arch Chiv

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In 16 patients operated on for mechanically caused ileus and in 12 control patients (cholecystectomy) local PO2 of the small bower wall was determined by means of a multiwire Pt surface electrode constructed by Kessler and Lübbers. The ileus patients showed an increased pulse rate of 110 (90-115) vs 90 (80-110) beats/min and creatinine levels of 1.06 (0.79-1.45) vs 0.80 (0.70-0.88) mg%. (mean, 1.-3. quartile, P less than 0.05). Local PO2 values of the serosal site of the small bowel were significantly reduced in patients with ileus compared to the control group [22.5 (12.5-35) vvs 61.2 (53.0-71.0) torr.] Hypoxia of the bower in mechanically caused ileus could be demonstrated by local PO2 determination and underlines the demand of early decompression.

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Spezielle pathologische Anatomie II

Cited by 6 publications

References 0 publications

Immunocytological detection of micrometastatic cells: Comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients

Immunocytological detection of micrometastatic cells: Comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients

Die Fettembolie der Lungen als Todesursache. Ätiologie, Pathogenese und Beweisführung

Die Sauerstoffversorgung des menschlichen D�nndarmes im mechanischen Ileus

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