Spermine prevent iron accumulation and depress lipofuscin accumulation in cultured myocardial cells

Marzabadi, Massoud R.; Løvaas, Erik

doi:10.1016/0891-5849(96)00038-x

Cited by 20 publications

(13 citation statements)

References 63 publications

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“…l ‐Ornithine is decarboxylated by ornithine decarboxylase to form putrescine, the precursor of the “higher” polyamines spermidine and spermine . Spermine concentration was increased in the rat plasma samples after RIPC, and there is evidence that polyamines, particularly spermine, play beneficial roles in calcium homeostasis in I/R injury settings, scavenging free radicals and reducing lipid peroxidation . It has been shown that both MI and I/R injury elicit the polyamine stress response characterized by increased ornithine decarboxylase and spermidine/spermine N ‐acetyltransferase activities, which lead to a depletion in spermine and spermidine .…”

Section: Discussionmentioning

confidence: 99%

“…42,43 Spermine concentration was increased in the rat plasma samples after RIPC, and there is evidence that polyamines, particularly spermine, play beneficial roles in calcium homeostasis in I/R injury settings, scavenging free radicals and reducing lipid peroxidation. 44,45 It has been shown that both MI and I/R injury elicit the polyamine stress response characterized by increased ornithine decarboxylase and spermidine/spermine N-acetyltransferase activities, which lead to a depletion in spermine and spermidine. [46][47][48] Supplying exogenous spermine prior to I/R injury has been found to restore intracellular polyamine pools and confer cardioprotective effects.…”

Section: Medication At Inclusionmentioning

confidence: 99%

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Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines

Barca

Bakhta

Kalakech

et al. 2016

JAHA

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BackgroundRemote ischemic preconditioning (RIPC) is an attractive therapeutic procedure for protecting the heart against ischemia/reperfusion injury. Despite evidence of humoral mediators transported through the circulation playing a critical role, their actual identities so far remain unknown. We sought to identify plasmatic RIPC‐induced metabolites that may play a role.Methods and ResultsRat plasma samples from RIPC and control groups were analyzed using a targeted metabolomic approach aimed at measuring 188 metabolites. Principal component analysis and orthogonal partial least‐squares discriminant analysis were used to identify the metabolites that discriminated between groups. Plasma samples from 50 patients subjected to RIPC were secondarily explored to confirm the results obtained in rats. Finally, a combination of the metabolites that were significantly increased in both rat and human plasma was injected prior to myocardial ischemia/reperfusion in rats. In the rat samples, 124 molecules were accurately quantified. Six metabolites (ornithine, glycine, kynurenine, spermine, carnosine, and serotonin) were the most significant variables for marked differentiation between the RIPC and control groups. In human plasma, analysis confirmed ornithine decrease and kynurenine and glycine increase following RIPC. Injection of the glycine and kynurenine alone or in combination replicated the protective effects of RIPC seen in rats.ConclusionsWe have hereby reported significant variations in a cocktail of amino acids and biogenic amines after remote ischemic preconditioning in both rat and human plasma.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01390129.

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Section: Discussionmentioning

confidence: 99%

Section: Medication At Inclusionmentioning

confidence: 99%

Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines

Barca

Bakhta

Kalakech

et al. 2016

JAHA

View full text Add to dashboard Cite

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“…A very significant function of polyamines is their antioxidant action: 1) Spermine, spermidine and putrescine act as free radical scavengers [32][33][34], and the ability of polyamines to bind toxic aldehydes has been shown [35]; 2) Polyamines have a chelating ability towards metal ions, thereby adjusting the triggering mechanisms of OS [36][37][38][39]; and 3) Spermine and spermidine can influence the activity of antioxidant enzymes, interacting with their corresponding DNA [40,41].…”

Section: The Antioxidant Effect Of Polyaminesmentioning

confidence: 99%

Polyamines in Parkinson’s Disease: Their Role in Oxidative Stress Induction and Protein Aggregation

et al. 2019

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Parkinson's disease (PD) is a systemic neurodegenerative disease characterized by tremor, rigidity, bradykinesia, and stooping posture. When more than 60% of dopaminergic neurons in the substantia nigra of the brain have died, motor symptoms manifest in PD. Currently, oxidative stress (OS) is considered to be one of the leading factors provoking death of dopaminergic neurons in PD. This review is concerned with the role of polyamines in PD, especially focusing on their role in OS induction. Polyamines (putrescine, cadaverine, spermidine and spermine) are involved in many molecular mechanisms, including cell proliferation and differentiation, gene transcription and translation, modulation of the functional activity of ion channels and receptors, and other vital processes. It is worth noting that under physiological conditions polyamines are antioxidants. It has been shown that spermine oxidase (SMOX) is up-regulated in PD, activating polyamine breakdown, which leads to excessive formation of toxic aldehydes (such as acrolein), H 2 O 2 (a strong cytostatic) and ammonia (a toxic substance). Polyamines are also involved in the pathogenetic mechanism of α-synuclein modification resulting in the formation of Lewy bodies. This review provides data on the changes in polyamine levels at later stages of the disease. The review also examines the role of polyamines, as gliotransmitters, in regulating neural function and vice versa. The mechanisms of polyamine "pumping" from neurons to glia can be considered factors of OS regulation in neurons. Prolonged accumulation of polyamines in glia can lead to oxidation of polyamines and therefore potentially to gliosis in PD. The exact mechanisms of this process are, however, not clear. Answering the questions regarding the role of polyamines in gliosis development and pathogenesis of PD is necessary for treating cognitive impairment in patients with PD, which is particularly important.

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“…It has been speculated that iron chelators that easily penetrate through cellular membranes could inhibit redox-active iron and lipofuscinogenesis. The literature reveals that two iron chelators, spermine or desferrioxamine, might be able to prevent lipofuscin formation and decrease oxidative stress in postmitotic cells (36). Recently, Kurtz observed that apoferritin, also a compound which binds to iron, could also prevent lipofuscin accumulation (37).…”

Section: Lysosomal Lipofuscinmentioning

confidence: 99%

Mechanisms of protein aggregation in the retinal pigment epithelial cells

Kaarniranta

Hyttinen²,

Ryhänen³

et al. 2010

Front Biosci

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The pathogenesis of age-related macular degeneration (AMD) essentially involves chronic oxidative stress, increased accumulation of lipofuscin in retinal pigment epithelial (RPE) cells and extracellular drusen formation, as well as the presence of chronic inflammation. The capacity to prevent the accumulation of cellular cytotoxic protein aggregates is decreased in senescent cells which may evoke lipofuscin accumulation into lysosomes in postmitotic RPE cells. This presence of lipofuscin decreases lysosomal enzyme activity and impairs autophagic clearance of damaged proteins which should be removed from cells. Proteasomes are another crucial proteolytic machine which degrade especially cellular proteins damaged by oxidative stress. This review examines the cross-talk between lysosomes, autophagy and proteasomes in RPE cell protein aggregation, their role as a possible therapeutic target and their involvement in the pathogenesis of AMD.

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Spermine prevent iron accumulation and depress lipofuscin accumulation in cultured myocardial cells

Cited by 20 publications

References 63 publications

Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines

Metabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines

Polyamines in Parkinson’s Disease: Their Role in Oxidative Stress Induction and Protein Aggregation

Mechanisms of protein aggregation in the retinal pigment epithelial cells

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