Spermine Modified PNIPAAm Nano-Hydrogel Serving as Thermo-Responsive System for Delivery of Cisplatin

Ghasemi, Soheila; Owrang, Marzieh; Javaheri, Farzad; Farjadian, Fatemeh

doi:10.1007/s13233-022-0035-7

Cited by 18 publications

(18 citation statements)

References 49 publications

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“…To investigate the pH impact of initial salt solution on the adsorption of Cu(II) by hydrogels, solutions of Cu(OAc)2.H2O (10 ppm) with different pH values (2, 4, 6, 8, 10, 12 and 14) were prepared. Hydrogel (V) (0.01 g) was added to the aqueous solution of Cu(OAc)2.H2O (2 mL, 10 mg L -1 ) of varied pH values (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and shacked for 24 h in order to achieve adsorption equilibrium at room temperature. Hydrogels were isolated by filtration and the filtrates were analyzed by ICP to determine the equilibrium concentration (Ce).…”

Section: Investigating the Effect Of Ph Of The Medium On The Adsorptionmentioning

confidence: 99%

“…In fact, they have the potential to reversible swelling or de-swelling in the presence of water and retain extensive amount of water in the swollen condition. Smart hydrogels that make a response instantly to the environmental changes have been widely used in drug delivery [10],…”

Section: Introductionmentioning

confidence: 99%

“…The progress of the reaction was followed through UV-Vis spectrophotometer in the range of 200-400 nm wavelengths at different time intervals (0, 2 and 4 min). The experiment was repeated at 45 ˚C and monitored at time intervals of5,10,15,20,25,30, 35, 40, 45, 50 and 55 min while other conditions were constant.…”

mentioning

confidence: 99%

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Kinetic and Equilibrium Function and Switchable Catalytic Activity of Some Thermo-Responsive Hydrogel Metal Absorbents Based on Modified PNIPAM

Ghasemi

Owrang

Javaheri

2022

Preprint

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Synthesis and identification of some thermo-responsive hydrogel metal absorbents based on Schiff base modified PNIPAM is described. PNIPAM hydrogel is produced through conventional free-radical polymerization method. The hydrogel is amino modified with different amines and then treated with various aldehydes to make polymeric Schiff-bases supposing to utilize as an absorbent for Cu salt. Characterization of the as-prepared hydrogels was performed properly and confirmed the corresponding structures. Kinetic and equilibrium function of the absorbents and the effect of distinct variables like pH, adsorbent amount and contact time in the absorption process are investigated in detail. Kinetic and adsorption isotherm data agreed with pseudo-second order model and Langmuir isotherm, respectively. The maximum value of adsorption capacity of the prepared adsorbent was around 8550 mg g-1. In addition, the corresponding switchable catalytic activity using one of the thermo-responsive hydrogel metal absorbents in the reduction of 4-nitro phenol to 4-amino phenol in the role of model reaction is examined.

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Section: Investigating the Effect Of Ph Of The Medium On The Adsorptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kinetic and Equilibrium Function and Switchable Catalytic Activity of Some Thermo-Responsive Hydrogel Metal Absorbents Based on Modified PNIPAM

Ghasemi

Owrang

Javaheri

2022

Preprint

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“…In continuation of our previous studies to design smart stimuli‐responsive nanohydrogels 24–29 and theranostic pH‐responsive fluorophore MS 30 for delivery of anticancer agents, herein, a colon‐specific DDS was introduced. In this project, amino‐functionalized mesoporous silica (MS‐NH 2 ) is synthesized and characterized.…”

Section: Introductionmentioning

confidence: 99%

“…21 They also reported that this MMS loaded with safranin O and hydrocortisone could be applied for colon drug delivery and could be administrated as a treatment for inflammatory bowel diseases. 22,23 In continuation of our previous studies to design smart stimuliresponsive nanohydrogels [24][25][26][27][28][29] and theranostic pH-responsive fluorophore MS 30 for delivery of anticancer agents, herein, a colon-specific DDS was introduced. In this project, amino-functionalized mesoporous silica (MS-NH 2 ) is synthesized and characterized.…”

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confidence: 99%

Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5‐fluorouracil

et al. 2022

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In this study, amino-functionalized mesoporous silica (MS) particles were synthesized and loaded with the anticancer drug, 5-Fu. In a post-modification reaction, the pores were gated by an azobenzene derivative to act as an enzyme-responsive drug delivery system. The synthesis and characterization of the MS structure were validated using various instrumental techniques such as XRD, N 2 adsorption/desorption, and FE-SEM and TEM. The loading efficiency and capacity of 5-Fu adsorption onto MS were evaluated; the adsorption isotherm graphs were plotted. The enzyme responsiveness feature of this nanocarrier was tested in the 5-Fu release study. The 5-Fu release from MS and the azo-capped compound was measured, and when sodium dithionite was used as a reducing agent and an azoreductase enzyme mimicker, the controlled release was observed. Finally, the cytotoxicity of 5-Fu loaded and azocapped MS in normal medium and sodium dithionate-containing medium was evaluated and compared with the cytotoxicity of the free drug.

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Development of fibroblast/endothelial cell‐seeded collagen scaffolds for in vitro prevascularization

et al. 2022

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The development of vascularized scaffolds remains one of the major challenges in tissue engineering, and co-culturing with endothelial cells is known as one of the possible approaches for this purpose. In this approach, optimization of cell culture conditions, scaffolds, and fabrication techniques is needed to develop tissue equivalents that will enable in vitro formation of a capillary network. Prevascularized equivalents will be more physiologically comparable to the native tissues and potentially prevent insufficient vascularization after implantation. This study aimed to culture human umbilical vein endothelial cells (HUVECs), alone or in co-culture with fibroblasts, on collagen scaffolds prepared by simple fabrication approaches for in vitro prevascularization. Different concentrations and ratios of HUVECs and fibroblasts seeded on collagen gel and sponge scaffolds under several culture conditions were examined. Cell viability, scaffolds morphology, and structure were analyzed. Collagen gel scaffolds showed good cell proliferation and viability, with higher proliferation rates for cells cultured in a 2:1 (fibroblasts: HUVECs) ratio and kept in endothelial cell growth medium. However, these matrices were unable to support endothelial cell sprouting. Collagen sponges were highly porous and showed good cell viability. However, they became fragile over time in culture, and they still lack signs of vascularization. Collagen scaffolds were a good platform for cell growth and viability. However, under the experimental conditions of this study, the HUVEC/fibroblast-seeded scaffolds were not suitable platforms to generate in vitro prevascularized equivalents.Our findings will be a valuable starting point to optimize culture microenvironments and scaffolds during fabrication of prevascularized scaffolds.

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Spermine Modified PNIPAAm Nano-Hydrogel Serving as Thermo-Responsive System for Delivery of Cisplatin

Cited by 18 publications

References 49 publications

Kinetic and Equilibrium Function and Switchable Catalytic Activity of Some Thermo-Responsive Hydrogel Metal Absorbents Based on Modified PNIPAM

Kinetic and Equilibrium Function and Switchable Catalytic Activity of Some Thermo-Responsive Hydrogel Metal Absorbents Based on Modified PNIPAM

Mesoporous silica nanostructure modified with azo gatekeepers for colon targeted delivery of 5‐fluorouracil

Development of fibroblast/endothelial cell‐seeded collagen scaffolds for in vitro prevascularization

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