Spermine and spermidine induce intestinal maturation in the rat

Dufour, Claire; Dandrifosse, Guy; Forget, Patricia; Vermesse, F.; Romain, Nadine; Lepoint, P.

doi:10.1016/0016-5085(88)90298-3

Cited by 162 publications

(124 citation statements)

References 9 publications

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“…This is the first report of intestinal tissue polyamine levels in neonatal pigs and the data are in good agreement with those published for the neonatal rat (Dufour et al, 1988). Intestinal tissue polyamines originate from several sources including de novo synthesis, translocation from other organs, diet (Bardocz et al, 1990) and luminal bacteria (Osbourne and Seidel, 1989).…”

Section: Milk Polyaminessupporting

confidence: 88%

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Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling

Kelly¹,

King²,

Brown³

et al. 1991

Reprod. Nutr. Dévelop.

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Section: Milk Polyaminessupporting

confidence: 88%

“…Putrescine (Dufour et al, 1988;Bardocz et al, 1990) it is plausible that milk polyamines are biologically significant to the developing intestine.…”

Section: Milk Polyaminesmentioning

confidence: 99%

Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling

Kelly¹,

King²,

Brown³

et al. 1991

Reprod. Nutr. Dévelop.

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“…In intestines of 14-day-old rats treated orally with spermine (at a concentration below the level of cytotoxicity and not exceeding the daily level eaten by weaned rats), the level of spermine was significantly higher than in the intestines of 14-day-old control rats and attained the level of weaned rats, as also described by Dufour et al [36]. The levels of the other polyamines (spermidine and putrescine) and of N-acetylspermidine and N-acetylspermine were not modified.…”

Section: Discussionsupporting

confidence: 74%

“…In suckling rats treated orally with spermine, the increase in the intestinal content of spermine in comparison with control rats is probably due to the intake, at the apical pole of the epithelial cells, of a higher quantity of this polyamine that is present in the gut lumen, rather than to a higher contribution via blood circulation, because intraperitoneal administration of spermine was without effect. Moreover, Dufour et al [36] and Buts et al [37] showed respectively either no modification or a decrease in the activity of the ornithine decarboxylase in suckling rats treated with spermine, indicating that the biosynthesis of spermine in enterocytes should not increase after the treatment of suckling rats with spermine.…”

Section: Discussionmentioning

confidence: 98%

“…It could be interesting to determine the nature of one of them (with a molecular mass of 100 kDa), which was more strongly revealed than the others and might be one of the glycoprotein enzymes of the brush border membrane (e.g. sucrase, maltase or aminopeptidase), also precociously induced after spermine ingestion [18,36]. However, it remains to be determined whether the precocious induction of intestinal fucosylation, observed in suckling rats treated orally with spermine, is due to a direct effect of polyamines after enterocyte penetration at the luminal side of the cell or to an indirect stimulated secretion of hormone or of other secondary effectors.…”

Section: Discussionmentioning

confidence: 99%

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Influence of spermine on intestinal maturation of the glycoprotein glycosylation process in neonatal rats

Greco

Hugueny

George

et al. 1999

Biochemical Journal

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Previous work has shown an inverse evolution of the rat intestinal glycoprotein sialylation that decreases from birth to weaning and of fucosylation that increases markedly after weaning during postnatal development. At weaning time, an increase in the intestinal level of polyamines (and especially that of spermine) was observed, owing partly to the higher level of spermine found in solid food given to rats at this period in comparison with the level found in milk. To study the role of this polyamine as a possible maturation factor of the glycoprotein glycosylation, suckling rats were treated for 4 days with spermine administered orally. This treatment allowed us to mimic the spermine increase that was observed naturally in rat small intestine after weaning because, in intestines of spermine-treated suckling rats, spermine was the only polyamine to be increased and was at a level similar to that of weaned rats. Spermine treatment did not induce appreciable changes in sialyltransferase activity or in sialylation of the brush-border-membrane glycoproteins. On the contrary,

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Exogenous spermine induces maturation of the liver in suckling rats

et al. 1996

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In the present study, we investigated the effects of spermine on postnatal liver maturation in suckling rats. The animals were given spermine either per os (8 micromol) or by intraperitoneal injection (1 micromol), once daily for three or five days. The percentage of liver cells in different cell cycle phases and of diploid cells in the parenchyma was estimated. The protein content, ornithine aminotransferase (OAT) activity, and content of DNA polyamines and receptors for polymeric immunoglobulins (RPI) were also measured in liver extracts. The ingestion of spermine had the following effects: the percentage of the cells in S and G2M phases of the cell cycle diminished the percentage of diploid cells increased the content of polymeric immunoglobulin receptors increased; the OAT activity increased; the contents of putrescine and spermidine decreased and almost reached adult values; and the spermidine/spermine ratio became similar to that observed in the liver of adult rats. These phenomena were detected 40 hours after the beginning of oral spermine treatment. The intraperitoneal injection of spermine had no effect on the OAT activity, but it decreased the spermidine content and enhanced the spermine content. Our data demonstrated for the first time that dietary polyamines play a role in the initiation of liver postnatal maturation in suckling rats.

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Spermine and spermidine induce intestinal maturation in the rat

Cited by 162 publications

References 9 publications

Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling

Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling

Influence of spermine on intestinal maturation of the glycoprotein glycosylation process in neonatal rats

Exogenous spermine induces maturation of the liver in suckling rats

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