Spermidine in Regenerating Liver: Relation to Rapid Synthesis of Ribonucleic Acid

Abstract

The spermidine in rat liver increases after partial hepatectomy, and the rate of polyamine accumulation closely approximates the increased rate of synthesis of RNA in regenerating liver. The uptake by the liver of intravenously injected putrescine and the biosynthesis of spermidine are accelerated within 2 hours after the operation. The uptake of spermidine also increases during early regeneration.

Polyamine‐promoted autoactivation of plasma hyaluronan‐binding protein

“…The polyamines, for example putrescine, spermidine and spermine, which accumulate in cells undergoing rapid growth, play a role in the regulation of proliferation, differentiation and programmed cell death [16,17]. In the rat liver, the concentration of spermidine and spermine is around 1 mM [18], and the spermidine concentration increases after partial hepatectomy [19]. As shown in Fig.…”

Reversible inhibition of rat liver regeneration by 1,3‐diamino‐2‐propanol, an inhibitor of ornithine decarboxylase

“…Rodent liver regeneration in response to tissue loss is characterized by an early and dramatic accumulation of putrescine [1] and spermidine [2,3] in the remaining liver remnant and results from an intense stimulation of the enzyme ornithine decarboxylase (EC 4.1.1.17) [4,5]. Several lines of experimental evidence suggest that the enhanced accumulation of polyamines is specifically required for a proper proliferative response of the liver tissue.…”

Effect of Aliphatic Polyamines on Growth and Macromolecular Syntheses in Bacteria

“…Previous work has shown that the antimicrobial action is maximal at alkaline pH values (Rozansky et al 1954) and that polyamines inhibit protein synthesis in growing bacteria (Razin & Rozansky, 1959;Friedman & Bachrach, 1966;Mills & Dubin, 1966;Ezekiel & Brockman, 1968), in bacterial extracts (Hershko, Amoz & Mager, 1961 ;Mager, Benedict & Artman, 1962;Martin & Ames, 1962) and in mammalian cells (Goldstein, 1965;Ochoa & Weinstein, 1965). On the other hand, RNA synthesis is stimulated by polyamines in low concentrations, while high concentrations exert an inhibitory effect (Doerfler, Zillig, Fuchs & Albers, 1962;Krakow, 1963;Fox, Robinson, Haselkorn & Weiss, 1964;Dykstra & Herbst, 1965;Goldstein, 1965;Mills & Dubin, 1966;O'Brien, Olenick & Hahn, 1966;Caldarera, Moruzzi, Barbiroli & Moruzzi, I 968 ; Moruzzi, Barbiroli & Caldarera, I 968 ; Petersen, Kroger & Hagen, I 968). Synthetic polyamines, resembling spermidine in their structure, behave like naturally occurring polyamines in that they stabilize RNA against thermal denaturation (Goldstein, 1966) and serve as growth factors for some lactobacilli (Guirard & Snell, 1964).…”