Spermidine-functionalized biomaterials to modulate implant-induced immune response and enhance wound healing

Wang, Li; Zhong, Yinghui; Wu, Qianqian; Wang, Yu; Tang, Ruoqi; Zhou, Silu; Yang, Jingde; Liu, Qiming; Shi, Guoxin; Tang, Yanan; Meng, Xianglong; Chen, Kexin; Yan, Xianqiang; Liu, Xuelei; Zhan, Jing; Roberts, Thomas M.; Liang, Song; Yu, Jiaao; Liu, Zhenning

doi:10.1016/j.cej.2023.146416

Cited by 3 publications

(5 citation statements)

References 57 publications

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“…Overall, PPC is hydrophobic with excellent barrier properties. The water contact angle (WCA) of PPC film is greater than 100° [ 78 ], indicating a high level of hydrophobicity. Moreover, PPC exhibits good gas barrier properties.…”

Section: Properties Of Ppcmentioning

confidence: 99%

“…For instance, parallel-aligned PPC microfibers, which have been treated with oxygen plasma and surface-modified with chitosan nanofibers, have demonstrated superior cell responses of fibroblasts in terms of morphology, adhesion and proliferation [ 16 ]. PPC with plasma treatment and surface modification of hydrogels containing chitosan, collagen and spermidine has exhibited low immunogenicity, which may improve its integration with cell and tissue and favor biomedical applications [ 78 ]. However, surface treatment methods may not be suitable for the large-scale production of PPC-based biomaterials.…”

Section: Modifications Of Ppcmentioning

confidence: 99%

“…This scaffold not only showed good cytocompatibility and low inflammatory response, but also functioned as an osteogenesis-inducer to promote bone repair in rabbits. Liu et al modified PPC with biopolymers and spermidine to prepare PPC-based artificial skin [ 78 ], which showed excellent mechanical properties, swelling properties, cytocompatibility, and pro-healing properties. More importantly, the PPC-based artificial skin exhibited low immunogenicity owing to the modification of spermidine, which is manifested by reduced pro-inflammatory cytokines in rats and accelerated transition from the M1 macrophage-dominated phase to the M2 macrophage-dominated phase.…”

Section: Biomedical Applications Of Ppcmentioning

confidence: 99%

“…( a ) A biodegradable PPC-starch-bioglass scaffold with improved biocompatibility and tissue integration [ 15 ]; (The arrows in H&E stainings represent tissue infiltration.) ( b ) spermidine-functionalized artificial skin to modulate implant-induced immune response and enhance wound healing [ 78 ]; ( c ) an osteoconductive PPC-poly(D-lactic acid)-β-tricalcium phosphate (PDT) scaffold for bone defect repair [ 131 ].…”

Section: Figurementioning

confidence: 99%

“…Electrospinning and oxygen plasma treatment [16] PPC nanofiber mats Electrospinning, spin coating and UV treatment [127] Curcumin-loaded PPC-g-chitosan nanofibers Electrospinning and encapsulation [128] Artificial skins Spermidine-functionalized PPC composite films Spin coating [78] Bone repair scaffolds Porous PPC-starch-bioglass scaffolds Gas foaming [15] PPC-starch composites Melt blending [93] Microporous PPC/laponite nanocomposites Melt blending and surface treatment with sodium hydroxide [114] PPC-starch-bioglass blends Melt blending [129] PPC multilayer membranes Aminolysis and layer-by-layer assembly [130] Porous PPC/poly(D-lactic acid)/β-tricalcium phosphate scaffolds Salt leaching [131] Medical adhesives/glues Poly(ethyl cyanoacrylate)/PPC/ caffeic acid films Polymerization in presence of PPC and solvent evaporation [132] Wearable electronic devices Poly(methyl methacrylate)-PC-lithium perchlorate/multi-walled carbon nanotube/Mn 3 O 4 micro-supercapacitors layer-by-layer-assembled films Hydrothermal reaction, photolithography and layer-by-layer assembly…”

Section: Parallel-aligned Ppc Microfibers/ Chitosan Nanofibersmentioning

confidence: 99%

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Poly(Propylene Carbonate)-Based Biodegradable and Environment-Friendly Materials for Biomedical Applications

Wang,

Li,

Yang

et al. 2024

IJMS

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Poly(propylene carbonate) (PPC) is an emerging “carbon fixation” polymer that holds the potential to become a “biomaterial of choice” in healthcare owing to its good biocompatibility, tunable biodegradability and safe degradation products. However, the commercialization and wide application of PPC as a biomedical material are still hindered by its narrow processing temperature range, poor mechanical properties and hydrophobic nature. Over recent decades, several physical, chemical and biological modifications of PPC have been achieved by introducing biocompatible polymers, inorganic ions or small molecules, which can endow PPC with better cytocompatibility and desirable biodegradability, and thus enable various applications. Indeed, a variety of PPC-based degradable materials have been used in medical applications including medical masks, surgical gowns, drug carriers, wound dressings, implants and scaffolds. In this review, the molecular structure, catalysts for synthesis, properties and modifications of PPC are discussed. Recent biomedical applications of PPC-based biomaterials are highlighted and summarized.

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Section: Properties Of Ppcmentioning

confidence: 99%

Section: Modifications Of Ppcmentioning

confidence: 99%

Section: Biomedical Applications Of Ppcmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Parallel-aligned Ppc Microfibers/ Chitosan Nanofibersmentioning

confidence: 99%

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Poly(Propylene Carbonate)-Based Biodegradable and Environment-Friendly Materials for Biomedical Applications

Wang,

Li,

Yang

et al. 2024

IJMS

Self Cite

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Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ

Wu,

Yang,

Fan

et al. 2024

Advanced Science

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The inflammatory response is a key factor affecting tissue regeneration. Inspired by the immunomodulatory role of spermidine, an injectable double network hydrogel functionalized with spermidine (DN‐SPD) is developed, where the first and second networks are formed by dynamic imine bonds and non‐dynamic photo‐crosslinked bonds respectively. The single network hydrogel before photo‐crosslinking exhibits excellent injectability and thus can be printed and photo‐crosslinked in situ to form double network hydrogels. DN‐SPD hydrogel has demonstrated desirable mechanical properties and tissue adhesion. More importantly, an “operando” comparison of hydrogels loaded with spermidine or diethylenetriamine (DETA), a sham molecule resembling spermidine, has shown similar physical properties, but quite different biological functions. Specifically, the outcomes of 3 sets of in vivo animal experiments demonstrate that DN‐SPD hydrogel can not only reduce inflammation caused by implanted exogenous biomaterials and reactive oxygen species but also promote the polarization of macrophages toward regenerative M2 phenotype, in comparison with DN‐DETA hydrogel. Moreover, the immunoregulation by spermidine can also translate into faster and more natural healing of both acute wounds and diabetic wounds. Hence, the local administration of spermidine affords a simple but elegant approach to attenuate foreign body reactions induced by exogenous biomaterials to treat chronic refractory wounds.

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Nanofibrillated cellulose reinforced polypropylene carbonate biocomposites with high mechanical properties, dimensional stability, and antibacterial properties

Li,

Zhang,

Cheng

et al. 2024

Polymer Composites

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Polypropylene carbonate (PPC) is a biodegradable polyester with excellent toughness and ductility that may be employed as carbon fixation materials in biomedicine, agriculture, and environmental engineering. However, relatively lower strength and poor dimensional stability hinder its extensive application. In this study, nanofibrillated cellulose (NFC) and chitosan (CS) were introduced as biobased reinforcements into PPC without compromising its biodegradability. Notably, the composites not only had improved strength but also enhanced toughness after the addition of NFC and CS. The tensile strength and Young's modulus were increased by 25% and 58% in the composites with 3 wt% NFC and 2 wt% CS additions compared to pure PPC. Interestingly, the PPC/NFC/CS composites exhibited superior dimensional stability and antibacterial property. Upon the addition of 3 wt% NFC and 2 wt% CS, the composites took 3 s recovering from 0° to 137°. Additionally, NFC and CS contribute to the hydrophilicity of PPC composites. These findings offer valuable insights into experimental data and preparation techniques to the utilization of PPC in engineering fields.Highlights The developed composites achieved maximum tensile strength (13.5 MPa). The composites with 2 wt% chitosan had effective antibacterial properties. All reinforced composites showed excellent dimensional stability. Nanofibrillated cellulose and chitosan had toughening and enhancing effect. The developed composites showed good hydrophilicity.

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Spermidine-functionalized biomaterials to modulate implant-induced immune response and enhance wound healing

Cited by 3 publications

References 57 publications

Poly(Propylene Carbonate)-Based Biodegradable and Environment-Friendly Materials for Biomedical Applications

Poly(Propylene Carbonate)-Based Biodegradable and Environment-Friendly Materials for Biomedical Applications

Spermidine‐Functionalized Injectable Hydrogel Reduces Inflammation and Enhances Healing of Acute and Diabetic Wounds In Situ

Nanofibrillated cellulose reinforced polypropylene carbonate biocomposites with high mechanical properties, dimensional stability, and antibacterial properties

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