Spermidine Alleviates Intrauterine Hypoxia-Induced Offspring Newborn Myocardial Mitochondrial Damage in Rats by Inhibiting Oxidative Stress and Regulating Mitochondrial Quality Control

Chai, Nannan; Zheng, Haihong; Zhang, Hao; Li, Lingxu; Yu, Xue; Wang, Liyi; Bi, Xin; Yang, Lihong; Niu, Tongxu; Liu, Xiujuan; Zhao, Yajun; Dong, Lijie

doi:10.5812/ijpr-133776

Cited by 5 publications

(4 citation statements)

References 55 publications

(74 reference statements)

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“…As it was lower in colostrum from parity group C compared to parity group A, it may hint at differences in the oxidative stress level of the mammary gland in the older sows. The higher concentration of spermidine in colostrum from parity group B was probably advantageous for neonatal survival ( Chai et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Variations in colostrum metabolite profiles in association with sow parity

Vötterl,

Schwartz-Zimmermann,

Lerch

et al. 2024

Translational Animal Science

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Information about the full spectrum of metabolites present in porcine colostrum and factors that influence metabolite abundances is still incomplete. Parity number appears to modulate the concentration of single metabolites in colostrum. This study aimed to 1) characterize the metabolome composition and 2) assess the effect of parity on metabolite profiles in porcine colostrum. Sows (n = 20) were divided into three parity groups: A) sows in parity 1 and 2 (n = 8), B) sows in parity 3 and 4 (n = 6), and C) sows in parity 5 and 6 (n = 6). Colostrum was collected within 12 h after parturition. A total of 125 metabolites were identified using targeted reversed phase high-performance liquid chromatography tandem mass spectrometry and anion-exchange chromatography-high resolution mass spectrometry. Gas chromatography additionally identified 19 fatty acids (FA). Across parities, colostrum was rich in creatine and creatinine, 1,3-dioleyl-2-palmitatoylglycerol, 1,3-dipalmitoyl-2-oleoylglycerol and sialyllactose. Alterations in colostrum concentrations were found for 8 metabolites among parity groups (P < 0.05) but effects were not linear. For instance, colostrum from parity group C comprised 75.4% more valine but 15.7, 34.1 and 47.9% less citric, pyruvic and pyroglutamic acid, respectively, compared to group A (P < 0.05). By contrast, colostrum from parity group B contained 39.5% more spermidine than from group A (P < 0.05). Of the FA, C18:1, C16:0 and C18:2 n-6 were the main FA across parities. Parity affected four FA (C18:3n3, C14:1, C17:0ai and C17:1), including 43.1% less α-linolenic acid (C18:3n3) in colostrum from parity group C compared to groups A and B (P < 0.05). Signature feature ranking identified 1-stearoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine and the secondary bile acid hyodeoxycholic acid as the most discriminative metabolites, showing a higher variable importance in the projection score in colostrum from parity group A than from groups B and C. Overall, results provided a comprehensive overview about the metabolome composition of sow colostrum. The consequences of the changes in colostrum metabolites with increasing parity for the nutrient supply of the piglets should be investigated in the future. The knowledge gained in this study could be used to optimize feeding strategies for sows.

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Section: Discussionmentioning

confidence: 99%

Variations in colostrum metabolite profiles in association with sow parity

Vötterl,

Schwartz-Zimmermann,

Lerch

et al. 2024

Translational Animal Science

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“…Interestingly, polyamine levels were considerably changed in the skeletal muscles of aged animals [90]. Furthermore, spermine could prevent hypoxia-induced ROS production and a reduction in mitophagy in cardiomyocytes [91]. Berberine has a therapeutic effect on cardiovascular health [92].…”

Section: Possible Treatment Tactics With Certain Small Molecules Agai...mentioning

confidence: 99%

Exogenous and Endogenous Molecules Potentially Proficient to Modulate Mitophagy in Cardiac Disorders

Nakashima,

Suga,

Matsuda

2024

Kinases and Phosphatases

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It has been proposed that procedures which upregulate mitochondrial biogenesis and autophagy by replacing damaged mitochondria with healthy ones may prevent the development of several heart diseases. A member of serine and threonine kinases, adenosine monophosphate-activated protein kinase (AMPK), could play essential roles in the autophagy and/or mitophagy. AMPK is widely distributed in various cells, which might play diverse regulatory roles in different tissues and/or organs. In fact, changes in the kinase function of AMPK due to alteration of activity have been linked with diverse pathologies including cardiac disorders. AMPK can regulate mitochondrial biogenesis via peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) signaling and also improve oxidative mitochondrial metabolism through inhibition of mechanistic/mammalian target of rapamycin (mTOR) pathway, which may also modulate the autophagy/mitophagy through autophagy activating kinase 1 (ULK1) and/or transforming growth factor beta (TGF-β) signaling. Therefore, the modulation of AMPK in autophagy/mitophagy pathway might probably be thought as a therapeutic tactic for several cardiac disorders. As kinases are amongst the most controllable proteins, in general, the design of small molecules targeting kinases might be an eye-catching avenue to modulate cardiac function. Some analyses of the molecular biology underlying mitophagy suggest that nutraceuticals and/or drugs including specific AMPK modulator as well as physical exercise and/or dietary restriction that could modulate AMPK may be useful against several heart diseases. These observations may virtually be limited to preclinical studies. Come to think of these, however, it is speculated that some nutraceutical regimens might have positive potential for managing some of cardiac disorders.

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“…Interestingly, polyamine levels were considerably changed in the skeletal muscles of aged animals [90]. Furthermore, spermine could prevent hypoxia-induced ROS production and the reduction of mitophagy in cardiomyocytes [91]. Berberine has a therapeutic effect on cardiovascular health [92].…”

Section: Possible Treatment Tactics With Certain Small Molecules Agai...mentioning

confidence: 99%

Nutraceuticals Modulating Mitophagy May Combat the Mitochondrial Dysfunction and Redox Stress in Several Cardiac Disorders

Nakashima,

Suga,

Matsuda

2024

Preprint

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It has been proposed that procedures which up-regulate mitochondrial biogenesis and autophagy by replacing damaged mitochondria with healthy ones, may prevent the development of several heart diseases. A member of serine and threonine kinases, AMPK, could play essential roles in the autophagy and/or mitophagy. AMPK is widely distributed in various cells, which might play diverse regulatory roles in different tissues and/or organs. In fact, changes in the kinase function of AMPK due to alteration of activity have been linked with diverse pathologies including cardiac disorders. AMPK can regulate mitochondrial biogenesis via PGC1α signaling and also improve oxidative mitochondrial metabolism through inhibition of mTOR pathway, which may also modulate the autophagy/mitophagy through ULK1 and/or TGF-β signaling. Therefore, the modulation of AMPK in autophagy/mitophagy pathway might be considered as a therapeutic tactic for several cardiac disorders. As kinases are amongst the most controllable proteins, in general, the design of small molecules targeting kinases might be an eye-catching avenue to modulate the cardiac function. Some analyses of the molecular biology underlying mitophagy suggests that nutraceuticals and/or drugs including specific AMPK modulator as well as physical exercise and/or dietary restriction that could modulate AMPK may be useful against several heart diseases. In particular, some nutraceutical regimens may have encouraging potential for controlling some of cardiac disorders.

show abstract

Spermidine Alleviates Intrauterine Hypoxia-Induced Offspring Newborn Myocardial Mitochondrial Damage in Rats by Inhibiting Oxidative Stress and Regulating Mitochondrial Quality Control

Cited by 5 publications

References 55 publications

Variations in colostrum metabolite profiles in association with sow parity

Variations in colostrum metabolite profiles in association with sow parity

Exogenous and Endogenous Molecules Potentially Proficient to Modulate Mitophagy in Cardiac Disorders

Nutraceuticals Modulating Mitophagy May Combat the Mitochondrial Dysfunction and Redox Stress in Several Cardiac Disorders

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