Spermicidal potential of saponins isolated from Indian medicinal plants

Setty, B.S.; Kamboj, V. P.; Garg, H. S.; Khanna, N. M.

doi:10.1016/0010-7824(76)90008-1

Cited by 39 publications

(16 citation statements)

References 2 publications

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“…All the other compounds acted virtually instantaneously. The spermicidal action of other triterpenoid saponin preparations has also been demonstrated (Stolzenberg & Parkhurst, 1974;Setty, Kamboj, Garg & Khanna, 1976).…”

Section: Triton N-101mentioning

confidence: 96%

Assessment of spermicides by a stripping technique against human spermatozoa

Brotherton¹

1977

Reproduction

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Fifty-two (52) compounds were tested for spermicidal activity by titration against human spermatozoa. The gradual decrease in mean sperm size was measured against increasing concentration of spermicide and the end-point was taken as the point at which all the peripheral cytoplasm had been removed and only the sperm core of nucleus and tail fibres remained. There were 14 compounds that produced this total effect. All were detergents, of various types, and the effect was purely physical. The most potent compounds caused complete stripping at 0.5-50 pmol/cell and most are already used in spermicidal preparations. A further 11 compounds, including sodium hypochlorite and some phenols, caused partial stripping, while 4 compounds caused sperm swelling. The test was not suitable for assessment of metabolic cell poisons.

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Section: Triton N-101mentioning

confidence: 96%

Assessment of spermicides by a stripping technique against human spermatozoa

Brotherton¹

1977

Reproduction

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“…Also, the authors demonstrated that the addition of exogenous rosemary or cysteine to the freezing extender positively affected post-thawed viability and acrosome integrity and was effective in penetration and cleavage rate (Malo et al, 2010). (Phytolaccaceae) (Stolzenberg & Parkhurst, 1974), (Setty, Kamboj, Garg, & Khanna, 1976) and Samanea saman (Jacq.) (Meliaceae) (Riar et al, 1991), Phytolacca dodecandra Hérit.…”

Section: Introductionmentioning

confidence: 99%

“…(Phytolaccaceae) (Stolzenberg & Parkhurst, 1974), Sapindus mukurossi Gaertn. (Sapindaceae) (Setty, Kamboj, Garg, & Khanna, 1976) and Samanea saman (Jacq.) Merr.…”

Section: Introductionunclassified

Essential oils rich in monoterpenes are unsuitable as additives to boar semen extender

et al. 2018

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Despite the development of efficient boar semen extenders, there is still room for improvement of new formulas using new molecules that could increase fertilisation outcomes and substitute cryoprotectants and antibiotics. The goal of this work was to evaluate if the essential oils from the leaves of Myrrhinium atropurpureum and Cymbopogon citratus are suitable as additives in boar semen extender. The major compounds found in the essential oils from M. atropurpureum were 1,8-cineole (37.37%) and terpinolene (19.18%); and geranial (49.8%) and neral (33.24%) in essential oil of C. citratus. The addition of 1% and 0.1% of both essential oils to extended semen had immediate spermicidal effects (p < 0.05). Lower concentrations were tested and no cytotoxic effect was observed when M. atropurpureum essential oil was added at 0.001%. Differently, essential oil from C. citratus reduced sperm motility, membrane functionality and integrity and mitochondrial membrane potential even in concentrations as low as 0.001%. Also, addition of essential oils in low concentrations had no inhibitory effect against Escherichia coli and Pseudomonas aeruginosa growth. We conclude that the essential oils from C. citratus and M. atropurpureum, rich in monoterpenes, are cytotoxic to swine spermatozoa, therefore unsuitable as semen extender additives.

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“…The interesting pharmacological properties associated with the Chinese drug “giwieng” are considered a panacea and other interesting biological activities such as spermicidal [133], molluscicidal [134], antimicrobial, anti-inflammatory, and cytotoxic activities [135]. Avicennia officinalis produces pharmacologically significant steroidal saponins, sapogenisis, and sapogenins.…”

Section: Chemical Constituents Of Marine Floramentioning

confidence: 99%

Anticancer Drugs from Marine Flora: An Overview

Boopathy

Kathiresan

2010

Journal of Oncology

254

127

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Marine floras, such as bacteria, actinobacteria, cyanobacteria, fungi, microalgae, seaweeds, mangroves, and other halophytes are extremely important oceanic resources, constituting over 90% of the oceanic biomass. They are taxonomically diverse, largely productive, biologically active, and chemically unique offering a great scope for discovery of new anticancer drugs. The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulphated polysaccharides. The chemicals have displayed an array of pharmacological properties especially antioxidant, immunostimulatory, and antitumour activities. The phytochemicals possibly activate macrophages, induce apoptosis, and prevent oxidative damage of DNA, thereby controlling carcinogenesis. In spite of vast resources enriched with chemicals, the marine floras are largely unexplored for anticancer lead compounds. Hence, this paper reviews the works so far conducted on this aspect with a view to provide a baseline information for promoting the marine flora-based anticancer research in the present context of increasing cancer incidence, deprived of the cheaper, safer, and potent medicines to challenge the dreadful human disease.

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Spermicidal potential of saponins isolated from Indian medicinal plants

Cited by 39 publications

References 2 publications

Assessment of spermicides by a stripping technique against human spermatozoa

Assessment of spermicides by a stripping technique against human spermatozoa

Essential oils rich in monoterpenes are unsuitable as additives to boar semen extender

Anticancer Drugs from Marine Flora: An Overview

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