2018
DOI: 10.1016/j.smallrumres.2018.07.017
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Spermatogonia survival in young ram lambs following irradiation, Busulfan or thermal treatment

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Cited by 6 publications
(9 citation statements)
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“…While busulfan treatment may appear practical in field conditions (as no expensive equipment is required), it has a clear disadvantage related to its systemic toxicity. The dose-dependent species-specific systemic toxicity of busulfan during treatment was demonstrated in pigs [138] and lambs [139]; therefore, researchers must be aware of the busulfan-related toxicity danger. In lambs, a dose of 8 mg/kg induced thin diarrhea with lethargy and a lack of appetite beginning at 5 days post busulfan injection; the authors suggested using reduced doses of busulfan [139].…”
Section: Ssc Transplantation: Fundamental For the Manipulation Of Spementioning
confidence: 99%
“…While busulfan treatment may appear practical in field conditions (as no expensive equipment is required), it has a clear disadvantage related to its systemic toxicity. The dose-dependent species-specific systemic toxicity of busulfan during treatment was demonstrated in pigs [138] and lambs [139]; therefore, researchers must be aware of the busulfan-related toxicity danger. In lambs, a dose of 8 mg/kg induced thin diarrhea with lethargy and a lack of appetite beginning at 5 days post busulfan injection; the authors suggested using reduced doses of busulfan [139].…”
Section: Ssc Transplantation: Fundamental For the Manipulation Of Spementioning
confidence: 99%
“…In our study, the testicular injection of shal rams with 1, 2 and 4 mg/kg of busulfan resulted in a dose dependent decrease in testis size and also spermatocytes population after 5 weeks of treatments. Systemic injection of busulfan reduced endogenous spermatogonia in the pre-pubertal ram (Olejnik et al, 2005), however, Olejnik et al (2018) reported that spermatogonia numbers were not significantly reduced by using 4 mg/kg busulfan intravenously, although 27% were changed, indicating that the power of their experiment was insufficient to detect a difference (Olejnik et al, 2018).…”
Section: Discussionmentioning
confidence: 98%
“…Nevertheless, animals in the 4 mg/kg group showed only mild clinical effects that were not life-threatening (Olejnik et al, 2005). However, Olejnik et al (2018) used a dose of 4 mg/kg in their experiment and reported a dramatic falls in white blood cells and platelets numbers, which were recovered within 3 weeks (Olejnik et al, 2018).…”
Section: Discussionmentioning
confidence: 99%
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