Sperm Retrieval Rates in Subgroups of Primary Azoospermic Males

Bromage, Stephen J.; Falconer, Debbie A.; Lieberman, Brian A.; Sangar, Vijay K; Payne, S. R.

doi:10.1016/j.eururo.2006.08.032

Cited by 61 publications

(44 citation statements)

References 21 publications

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“…Other finding of this study is higher values of FSH were observed in the NOA that motivated with Bromage SJ.et al, 2007 when say the serum concentration of FSH is inversely correlated with the impairment of spermatogenesis (17) .…”

Section: Discussion:-supporting

confidence: 75%

Evaluation of Inhibin B and FSH in Serum and Seminal Plasma in Different Groups of Infertile Men.

Anbary¹,

Taay²,

Kawaz³

et al. 2017

IJAR

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Section: Discussion:-supporting

confidence: 75%

Evaluation of Inhibin B and FSH in Serum and Seminal Plasma in Different Groups of Infertile Men.

Anbary¹,

Taay²,

Kawaz³

et al. 2017

IJAR

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“…Thanks to the implementation of ICSI, embryologists have progressively been able to treat patients with severe oligospermia or even azoospermia when surgical sperm retrieval could be attempted with success. Indeed, microepididymal sperm aspiration (MESA) can be attempted in cases of obstructive azoospermia (OA) with very high success rates (>90 %), and testicular sperm extraction (TESE) can be attempted in non-obstructive azoospermia (NOA) cases, albeit with lower success rates [2].…”

Section: Introductionmentioning

confidence: 99%

Does sperm origin affect embryo morphokinetic parameters?

Lammers

Reignier

Splingart

et al. 2015

J Assist Reprod Genet

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Purpose The purpose of our study was to use time-lapse in order to evaluate the impact of sperm origin (fresh ejaculate or surgically retrieved) on embryo morphokinetic parameters and clinical outcome in intracytoplasmic sperm injection (ICSI) cycles. Methods This retrospective monocentric study was conducted in 485 unselected couples undergoing 604 ICSI cycles with embryo culture in the Embryoscope®. Among them, 445 couples underwent ICSI cycle with fresh ejaculated sperm and 40 with surgically retrieved sperm (26 with testicular sperm and 14 with epididymal sperm). Embryo morphokinetic parameters and clinical cycle outcome were compared between fresh ejaculated sperm and surgically retrieved sperm. A subgroup analysis was also conducted between testicular and epididymal sperm ICSI cycles.Results Clinical outcome was comparable between groups according to sperm origin. Although most early morphokinetic parameters were comparable between ejaculated and surgical sperm groups, a few parameters were significantly different between both groups, but with a considerable overlap in their distribution. Late cellular events occurred significantly later in the surgical sperm group than in the ejaculated sperm group. Conclusions Morphokinetic analysis did not allow us to identify clinically relevant differences between fresh ejaculate and surgically retrieved sperm groups. Further studies are needed, especially concerning the relationship between sperm origin and late morphokinetic parameters, such as blastocyst development.

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“…However, it seems that the technique used for sperm retrieval plays a major role. Bromage et al (2007) reported that the probability of testicular sperm retrieval using random TESE is decreased in NOA men with elevated FSH levels [55]. Conversely, demonstrated that retrieval rates were nearly identical (~60% success rate) regardless of FSH levels by using micro-TESE; these authors showed that preoperative FSH level of ≥15 IU/L resulted in greater odds of finding sperm with micro-TESE compared with normal FSH values [56].…”

Section: Sperm Retrieval: Predictive Factors and Techniquesmentioning

confidence: 93%

What is New in the Clinical Assessment and Treatment of the Infertile Male

Esteves¹

2011

TORSJ

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Male infertility is a fast-evolving area. Recently published evidence has challenged several established concepts and added to the knowledge in the field. Traditionally, the clinical assessment of the subfertile male includes a history and physical examination, hormonal evaluation and semen analyses. Regarding the latter, the World Health Organization has established new reference values that in general include lower limits than those of previous editions. Specialized sperm function assays, such as sperm DNA integrity and measurements of oxidative stress, are now clinically available and may be integrated to the conventional semen analysis to provide a more comprehensive evaluation of a man's fertility status. Also, molecular biology genetic testing involving the Y-chromosome can correctly identify oligozoospermic and azoospermic men misdiagnosed as having idiopathic infertility and be of prognostic value for sperm retrieval in non-obstructive azoospermia. In the field of treatment, emerging evidence suggests that antioxidant therapy along with life-style modifications improve the male reproductive health. Microsurgery has increased the success rates for both varicocele treatment and sperm retrieval for assisted conception. Microsurgical treatment of clinical varicoceles may optimize reproductive outcome of couples undergoing intracytoplasmic sperm injection or microsurgical testicular sperm extraction. Men with non-obstructive azoospermia, elevated follicle-stimulating hormone levels and small testes may no longer be considered sterile. Modern retrieval techniques are used to collect testicular sperm that can be used to produce a healthy biological offspring via assisted conception. This article reviews what is new in the clinical assessment and treatment of the infertile male, including the implications of this increased knowledge in the management of the infertile couple and assisted reproduction technology outcomes.

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Sperm Retrieval Rates in Subgroups of Primary Azoospermic Males

Cited by 61 publications

References 21 publications

Evaluation of Inhibin B and FSH in Serum and Seminal Plasma in Different Groups of Infertile Men.

Evaluation of Inhibin B and FSH in Serum and Seminal Plasma in Different Groups of Infertile Men.

Does sperm origin affect embryo morphokinetic parameters?

What is New in the Clinical Assessment and Treatment of the Infertile Male

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