Sperm Production Rates, Sperm Physiology and Fertility in Rats Chronically Treated with Sublethal Doses of Aflatoxin B1

Egbunike, G. N.; Emerole, Godwin O.; Aire, Tom A.; Ikegwuonu, Fidelis I.

doi:10.1111/j.1439-0272.1980.tb01702.x

Cited by 30 publications

(17 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are parallel with other studies of Japanese quail (35), Leghorn chickens (1), rats (47,48) and roosters (49). They reported degeneration and desquamation in the epithelium decrease in the size and thickness of the germinative layer of seminiferous tubules and lowered plasma testosterone levels.…”

Section: Discussionsupporting

confidence: 90%

“…They reported degeneration and desquamation in the epithelium decrease in the size and thickness of the germinative layer of seminiferous tubules and lowered plasma testosterone levels. These findings may be due to the direct effects of AFB1 on seminiferous tubules, responsible for sperm production or due to its effect on the duct system responsible for sperm maturation (47). It could be also due to reduction in rates of oxygen consumption by adenosine diphosphate (ADP) utilization in gonadal mitochondria (50).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Phytic Acid Exposure Alters AflatoxinB1‐Induced Reproductive and Oxidative Toxicity in Albino Rats (Rattus norvegicus)

El-Saad

Mahmoud

2007

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The increased use of feed in Egypt's aquaculture and animal industries raises concerns about the possible presence of mycotoxins in feedstuffs. The use of alternative medicine, such as botanicals and nutritional supplements, has become popular with inflammatory cases. The present study aimed to testify the role played by phytic acid (IP6) in enhancing the reproductive and oxidative toxicity induced in aflatoxinB1 (AFB1) treated white male albino rats (Rattus norvegicus) throughout treatment and withdrawal periods. One hundred and twenty white male albino rats were grouped into four groups. Group 1, was injected with 300 μg kg−1 body wt of AFB1 once every 3 days for 15 days and left uninjected for another 15 days to study the withdrawal effect. Group 2, was injected with 300 μg kg−1 body wt of AFB1 once every 3 days for 15 days and treated simultaneously with IP6 daily for another 15 days. Group 3, was treated daily with IP6 (40 mg kg−1 body wt) for 15 days and with no treatment for other 15 days. Group 4, injected with equivalent volume of sterile phosphate buffer saline solution as a control group. Sera were taken at the experimental intervals and assayed for testosterone hormone, follicular-stimulating hormone (FSH) and luteinizing hormone (LH) to determine the toxicological impact of AFB1 and the possibility of amelioration by phytic acid on the reproductive performance of the studied animal. The effects of AFB1 treatment on the absolute and relative weight of testis as well as its histopathologic effect on the testis and the possibility of amelioration by IP6 treatment were evaluated. The activities of enzymatic and non-enzymatic anti-oxidants, in addition to lipid peroxidation were measured in the testis’ homogenate of AFB1-treated rats. A decrease in sex hormone levels, an increase in testicular lipid peroxidation product levels and a significant decrease in testicular glutathione content, catalase and total peroxidase and superoxide dismutase activities were recorded. The histopathologic alterations revealed a degeneration and highly mitotic division within the spermatogenic nuclei, in addition to some karyomegaly and nuclear pyknosis. It is concluded that the reduction in the toxicity of free radicals by phytic acid might be responsible for the protective influence observed.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Phytic Acid Exposure Alters AflatoxinB1‐Induced Reproductive and Oxidative Toxicity in Albino Rats (Rattus norvegicus)

El-Saad

Mahmoud

2007

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Aflatoxin B 1 is the most potent naturally occurring carcinogen (Ayyat et al, 2013;Binder et al, 2007). The toxicity of AFB 1 has been known to lead to poor growth, behavioral abnormalities, immunity inhibition, necrotic hepatocytes, reproduction damage and the residues of aflatoxins in liver and other edible tissues (Binder et al, 2007;Bintvihok et al, 2002;Deng et al, 2010;Egbunike et al, 1980;Farabi et al, 2006;Groopman et al, 1996;Sahoo and Mukherjee, 2001). However, very few studies have been carried out on the contamination, as well as the effects of AFB 1 in farmed aquafeeds (Barbosa et al, 2013).…”

mentioning

confidence: 99%

Effect of dietary aflatoxin B 1 on growth, fecundity and tissue accumulation in gibel carp during the stage of gonad development

et al. 2014

View full text Add to dashboard Cite

“…Ortatatli et al, (2002) observed focal lymphoid cell infiltration in testes in adult roosters fed AF-contaminated diet, which has already been reported to occur in other organs such as liver, kidney and pancreas due to aflatoxicosis (Dafalla et al, 1987;Esapda et al, 1997;Kiran et al, 1998). Evidence for impairment of Leydig cell function with a resultant drop in testosterone in testis preceding disruption of spermatogenesis in rats was provided by Egbunike et al, (1980Egbunike et al, ( , 1982. Recently, Abu El-Saad & Mahmoud, (2009) found decreased levels of FSH, LH and testosterone in AF-treated rat.…”

mentioning

confidence: 94%

A Comprehensive Review of Male Reproductive Toxic Effects of Aflatoxin

Akbarsha¹,

Kunnathodi²,

Alshatwi³

2011

Aflatoxins - Biochemistry and Molecular Biology

View full text Add to dashboard Cite

Sperm Production Rates, Sperm Physiology and Fertility in Rats Chronically Treated with Sublethal Doses of Aflatoxin B1

Cited by 30 publications

References 16 publications

Phytic Acid Exposure Alters AflatoxinB1‐Induced Reproductive and Oxidative Toxicity in Albino Rats (Rattus norvegicus)

Phytic Acid Exposure Alters AflatoxinB1‐Induced Reproductive and Oxidative Toxicity in Albino Rats (Rattus norvegicus)

Effect of dietary aflatoxin B 1 on growth, fecundity and tissue accumulation in gibel carp during the stage of gonad development

A Comprehensive Review of Male Reproductive Toxic Effects of Aflatoxin

Contact Info

Product

Resources

About