Sperm populations in the female genital tract of the rabbit

Cohen, Jack; Tyler, K. R.

doi:10.1530/jrf.0.0600213

Cited by 31 publications

(19 citation statements)

References 13 publications

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“…These findings again are inconsistent with the conclusion (Cohen & McNaughton, 1974;Cohen & Tyler, 1980) that spermatozoa transported naturally represent an elite population. In both these studies, the competence of naturally transported spermatozoa was compared to that of washed ejaculated spermatozoa following their mixed insemination directly into the uterine horns of a second doe.…”

Section: Discussioncontrasting

confidence: 56%

Fertilizing rabbit spermatozoa are not selected as a special population by the female tract

Foldesy¹,

Bedford²,

Orgebin‐Crist³

1984

Reproduction

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The survival of rabbit embryos from eggs fertilized by spermatozoa passing naturally from the vagina to the ampulla of the oviduct was compared with that of eggs fertilized by 'unselected' spermatozoa inseminated directly into the oviduct. After their transfer at the 2-cell stage to recipient does, embryos derived from fertilization with 'unselected' spermatozoa (57%) survived as well as those eggs fertilized by the natural 'selected' ampullary population (62%). Spermatozoa taken from the uterus 4 h post coitum ('selected' by virtue of having passed the cervix) were not competitively superior to an equal number of spermatozoa from the ejaculate of the same buck. The results do not support the suggestion that the reproductive tract of the female rabbit selects a genetically elite subpopulation of spermatozoa from the ejaculate.

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Section: Discussioncontrasting

confidence: 56%

Fertilizing rabbit spermatozoa are not selected as a special population by the female tract

Foldesy¹,

Bedford²,

Orgebin‐Crist³

1984

Reproduction

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“…Similarly, Cohen & Tyler (1980) found that the first few spermatozoa to pass through the rabbit cervix were uncoatable by IgG and were also very fertile when transferred to the uteri of recipient does. It is therefore possible that the cervix normally only permits a few spermatozoa to reach the site of fertilization, perhaps discriminating on IgG binding affinity (Cohen & Werrett, 1975; but see Taylor, 1982 …”

Section: Discussionmentioning

confidence: 87%

“…There is also evidence that sperm-induced leucocytosis occurs in the human cervix (I. Pandya, unpublished observations). Tyler (1977b) and Cohen & Tyler (1980) Parker, 1970).…”

Section: Introductionmentioning

confidence: 99%

Investigation of sperm-induced cervical leucocytosis by a double mating study in rabbits

Taylor¹

1982

Reproduction

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“…2) The fertilizing potential of spermatozoa recovered from the oviduct (as expressed by the number of spermatozoa that should be supplied for fertilizing an egg, or by the time required for penetration of eggs in vitro) is much higher than that of ejaculated spermatozoa or spermatozoa recovered from the uterus [20][21][22]. 3) In mammals, a considerable fraction of the spermatozoa ejaculated into the female reproductive tract is retained with reduced motility in storage sites; when ovulation occurs, some of them resume high motility and travel the distance between the storage and the fertilization sites within minutes [23][24][25][26] (see [5] for review).…”

Section: Discussionmentioning

confidence: 99%

Sequential Acquisition of Chemotactic Responsiveness by Human Spermatozoa1

Cohen-Dayag

Ralt

Tur-Kaspa

et al. 1994

Biology of Reproduction

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Recent studies have indicated that human spermatozoa respond to follicular fluid by attraction to chemotactic factor(s) in the fluid, accompanied by enhancement of motility and ultimately hyperactivation. In this study, we quantified the sperm response. We exposed spermatozoa to a gradient of a chemotactically active fraction of follicular fluid (denoted as "the attractant") and separated the spermatozoa that accumulated in the attractant and those that did not. We thus obtained two subpopulations: one enriched with chemotactically responsive spermatozoa, and one deficient in such spermatozoa. The fraction of the responsive spermatozoa out of the total sperm population was 2-12% at any measured time point. With time, the responsive spermatozoa lost their ability to be attracted, while such activity was gradually acquired by the subpopulation originally deficient in responsive spermatozoa. These results indicate that the identity of responsive spermatozoa is continuously changing. If the in vitro results are representative of the physiological conditions in vivo, they imply that the role of sperm chemotaxis combined with enhanced motility may be to select capacitated spermatozoa and bring them to the egg. Such a mechanism may, over an extended period of time, increase the prospect that an egg will meet capacitated spermatozoa as soon as it ovulates.

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Sperm populations in the female genital tract of the rabbit

Cited by 31 publications

References 13 publications

Fertilizing rabbit spermatozoa are not selected as a special population by the female tract

Fertilizing rabbit spermatozoa are not selected as a special population by the female tract

Investigation of sperm-induced cervical leucocytosis by a double mating study in rabbits

Sequential Acquisition of Chemotactic Responsiveness by Human Spermatozoa1

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