Sperm origins and concentration do not impact the clinical outcomes in intracytoplasmic sperm injection cycles

Yang, Cen; Zhou, Zehong; Zheng, Danni; Xu, Xiaofei; Huang, Jin; Lian, Ying; Qiao, Jie

doi:10.4103/aja.aja_27_18

Cited by 7 publications

(1 citation statement)

References 44 publications

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“…This is complying with the many studies which suggest that the severe sperm motility problems are overcome by ICSI, and outcome of ICSI in severe sperm abnormality is similar to those with normal sperm parameters. [ 17 18 19 20 ]…”

Section: Discussionmentioning

confidence: 99%

Evaluating the contribution of oocyte, sperm, and uterus in determining the outcome of intracytoplasmic sperm injection – A retrospective observational comparative study on intracytoplasmic sperm injection using own oocytes and donor oocytes

Shanthi¹,

Gopinath²,

Kumar³

et al. 2021

J Hum Reprod Sci

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Context: Several studies have assessed the contribution of oocyte, sperm, and endometrium on the outcome of intracytoplasmic sperm injection (ICSI) separately. This study assesses the relative contribution of oocyte, sperm, and uterus in achieving clinical pregnancy (CP) through ICSI by comparing own and third-party ICSI cycles. Aim: The aim of the study is to evaluate and compare the strength of contribution of oocyte, sperm, and uterus in achieving CP through ICSI. Settings and Design: This retrospective observational study of ICSI cycles for 20 months including 1000 embryo transfers (ETs). Methodology: Subjects were divided into two groups, Group 1 – ICSI with own oocytes (550 ETs) and Group 2 – ICSI with donor oocytes (450 ETs). Both the groups had 3 subgroups – a (husband sperm, transferred to self), b (donor sperm, transferred to self), c (husband sperm, transferred to a gestational surrogate). CP rate (CPR) as a major outcome was studied in the groups and subgroups. Statistical Analysis: CPR was compared between various subgroups using Z -test and Chi-square of significance of difference between proportions. A P < 0.05 was taken as the level of statistical significance. Results: CPR in subgroup 1a < 35 years, 1a ≥35 years, and 2a was 42.98%, 26.21%, and 40.92%, respectively ( P = 0.001). CPR was compared between 2a and 2c (40.92%, 56.5%, P = 0.044) and between 2a and 2b (40.92%, 42.11%, P = 0.866). Implantation rate was highest in Group 2c (34.88%) compared to other subgroups. Conclusion: The higher CPR in women <35 years undergoing ICSI with own oocytes than older women and a comparable CPR as that of recipients of donor oocytes suggests that age thereby oocyte quality is the strongest determining factor in achieving clinical pregnancy. Among oocyte recipients, higher CPR in surrogate uterus than patient uterus suggests that uterus/endometrium plays a considerable role, and comparable CPR between ICSI using husband sperm and donor sperm indicates that sperm quality might not play a major role in achieving CP.

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Section: Discussionmentioning

confidence: 99%

Evaluating the contribution of oocyte, sperm, and uterus in determining the outcome of intracytoplasmic sperm injection – A retrospective observational comparative study on intracytoplasmic sperm injection using own oocytes and donor oocytes

Shanthi¹,

Gopinath²,

Kumar³

et al. 2021

J Hum Reprod Sci

View full text Add to dashboard Cite

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Oligoasthenospermia is correlated with increased preeclampsia incidence in subfertile couples undergoing in vitro fertilization and embryo transfer: a secondary analysis of a randomized clinical trial

Guo,

Lan

et al. 2024

F&S Science

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Sperm source does not affect the ICSI outcome of patients with severely compromised spermatogenesis

Caroppo¹,

Campagna

Colpi³

et al. 2020

Andrologia

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Patients with spermatogenic dysfunction may display sperm parameters ranging from extremely severe oligozoospermia (sperm count lower than 2 million/ml) to azoospermia. It has been proposed that, since these patients may have increased sperm DNA damage that could affect their ICSI outcome, the use of surgically retrieved testicular spermatozoa should be preferred to improve their chance of fathering their biological offspring. However, studies in this field have yielded conflicting results. The present study provides an updated assessment of this subject by comparing the ICSI outcome of 762 patients with nonobstructive azoospermia and 419 with sperm count lower than 2 million/ml (median sperm count 300,000/ml). Both groups were homogeneous for the number of retrieved and injected MII oocytes. No difference was seen in terms of fertilisation, clinical pregnancy and cumulative live birth rates. Only the number of injected MII oocytes was found to independently predict the live birth rate, even when adjusted for the number of transferred embryos (OR 1.10 (1.0–1.2, p = 0.038)). The results of the present study stand against the use of testicular spermatozoa in patients with extremely severe spermatogenic dysfunction with available spermatozoa in their ejaculate.

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Sperm origins and concentration do not impact the clinical outcomes in intracytoplasmic sperm injection cycles

Cited by 7 publications

References 44 publications

Evaluating the contribution of oocyte, sperm, and uterus in determining the outcome of intracytoplasmic sperm injection – A retrospective observational comparative study on intracytoplasmic sperm injection using own oocytes and donor oocytes

Evaluating the contribution of oocyte, sperm, and uterus in determining the outcome of intracytoplasmic sperm injection – A retrospective observational comparative study on intracytoplasmic sperm injection using own oocytes and donor oocytes

Oligoasthenospermia is correlated with increased preeclampsia incidence in subfertile couples undergoing in vitro fertilization and embryo transfer: a secondary analysis of a randomized clinical trial

Sperm source does not affect the ICSI outcome of patients with severely compromised spermatogenesis

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