Sperm motility in the semen analysis affects the outcome of superovulation intrauterine insemination in the treatment of infertile Asian couples with male factor infertility

Lee, Vincent M.S.; Wong, Joycelyn S.Y.; Loh, S. K. E.; Leong, N. K. Y.

doi:10.1111/j.1471-0528.2002.01034.x

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…In the present study, we found that couples with higher pre-preparation sperm motility showed better pregnancy outcomes in IUI cycles. This finding is consistent with the results of previous studies [19][20][21][22]. The change in motility during sperm preparation, which we initially tried to study, was found to be fewer in cycles that resulted in pregnancy than in those that did not.…”

Section: Discussionsupporting

confidence: 92%

Predictive value of sperm motility before and after preparation for the pregnancy outcomes of intrauterine insemination

Jeong

Kim

et al. 2021

Clin Exp Reprod Med

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Objective: This study aimed to investigate sperm motility and its changes after preparation as predictors of pregnancy in intrauterine insemination (IUI) cycles.Methods: In total, 297 IUI cycles from January 2012 to December 2017 at a single tertiary hospital were retrospectively analyzed. Patient and cycle characteristics, and sperm motility characteristics before and after processing were compared according to clinical pregnancy or live birth as outcomes.Results: The overall clinical pregnancy rate per cycle was 14.5% (43/297) and the live birth rate was 10.4% (30/289). Patient and cycle characteristics were similar between pregnant and non-pregnant groups. Sperm motility after preparation and the total motile sperm count before and after processing were comparable in terms of pregnancy outcomes. Pre-preparation sperm motility was significantly higher in groups with clinical pregnancy and live birth than in cycles not resulting in pregnancy (71.4%±10.9% vs. 67.2%±11.7%, p=0.020 and 71.6%±12.6% vs. 67.3%±11.7%, p=0.030, respectively). The change in sperm motility after processing was significantly fewer in the non-pregnant cycles, both when the comparison was conducted by subtraction (post-pre) and division (post/pre). These relationships remained significant after adjusting for the female partner’s age, anti-Müllerian hormone level, and number of pre-ovulatory follicles. According to a receiver operating characteristic curve analysis, an initial sperm motility of ≥72.5% was the optimal threshold value for predicting live birth after IUI.Conclusions: Initial sperm motility, rather than the motility of processed sperm or the degree of change after preparation, predicted live birth after IUI procedures.

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Section: Discussionsupporting

confidence: 92%

Predictive value of sperm motility before and after preparation for the pregnancy outcomes of intrauterine insemination

Jeong

Kim

et al. 2021

Clin Exp Reprod Med

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“…Multiple studies have shown that IUI outcomes are affected by the percentage of motile sperm and total motile sperm count (Shulman et al, 1998;Pasqualotto et al, 1999;Lee et al, 2002;Miller et al, 2002;Yalti et al, 2004;Zhao et al, 2004). This effect on IUI outcomes has been demonstrated with both the percentage of motile sperm in the unprocessed ejaculate (Lee et al, 2002;Yalti et al, 2004;Zhao et al, 2004) and postprocessed sperm motility (Shulman et al, 1998;Pasqualotto et al, 1999). Both percentage of motile sperm and TMSC in unprocessed semen have been shown to influence IVF outcomes (Donnelly et al, 1998;Van Voorhis et al, 2001;Repping et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Sperm motility is an important factor to consider in couples pursuing assisted reproductive technologies (ARTs). Several studies have demonstrated the influence of sperm motility on the outcomes of various ARTs, including intrauterine insemination (IUI; Lee et al, 2002;Yalti et al, 2004;Zhao et al, 2004), conventional in vitro fertilization (IVF; Donnelly et al, 1998;Repping et al, 2002), and IVF with intracytoplasmic sperm injection (ICSI; Stalf et al, 2005). Although the exact total motile sperm count (TMSC) cutoff for defining severe male factor infertility varies somewhat among studies, a TMSC of 10 million in the ejaculate has been reported to be a useful threshold for decisions about treating a couple with IUI or IVF (Van Voorhis et al, 2001).…”

mentioning

confidence: 99%

Temporal Decreases in Sperm Motility: Which Patients Should Have Motility Checked at Both 1 and 2 Hours After Collection?

Schulte

Keller

Hiner

et al. 2008

Journal of Andrology

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A decrease in sperm motility, and thus total motile sperm count (TMSC), over a period of hours might have clinical implications in counseling couples considering intrauterine insemination (IUI), in vitro fertilization (IVF), and intracytoplasmic sperm injection (ICSI). The objective of this study was to identify patients with decreases in sperm motility from 1 to 2 hours after collection and examine predictive relationships with semen analysis parameters. Between 2001 and 2005, 2313 semen samples were analyzed. Sperm motility was evaluated at both 1 and 2 hours after time of collection. Relevant seminal parameters were compared between patients, with a decrease in 1-hour to 2-hour motility (n 5 384) compared with those that showed no change (n 5 1929). The same analysis was performed in a subset of patients with a TMSC between 10 and 40 million. In the total patient population, only 16% (384/ 2313) demonstrated a decrease in 1-hour to 2-hour motility. In patients displaying a decrease in the 1-2-hour motility, sperm concentration (33.5 vs 79 million/mL, P , .0001) and percent normal morphology (7% vs 8%, P , .0001) were significantly lower. Additionally, a significantly higher incidence of 1-2-hour motility decrease was seen in patients with midpiece anomalies (33.3% vs 15.9%, P 5 .01). Within the subpopulation of 10-40 million TMSC, the only statistically significant difference was in patients with midpiece anomalies (80.0% vs 28.2%, P 5 .02) who demonstrated a higher incidence of the 1-2-hour motility decrease. Overall, patients with a TMSC between 10 and 40 million showed a significantly higher incidence of 1-2-hour motility decrease compared with the rest of the patient population (29.0% vs 14.6%, P , .0001). Because decreases in 1-2-hour sperm motility affect only a small portion of patients, it is not necessary to check 2-hour motility on all patients. However, because patients with a TMSC between 10 and 40 million were significantly more likely to show a decrease in sperm motility-a decrease that could have possible clinical implications in couples deciding between IUI, IVF, or ICSI-checking 2-hour sperm motility should be considered in this population.

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“…The criteria for patient selection for IUI depends principally on the TMC together with the presence of normal female ovulation and patent reproductive tract. In general, at least 5 million motile sperm should be present in fresh semen samples and at least 1 million sperm should be inseminated after sperm preparation [ 119 ]. While the patient in this clinical scenario can be offered IUI, attempts at further increasing his TMC or protect his sperm parameters against OS induced injury by sperm preparation methods should be favored to improve his IUI outcome.…”

Section: Antioxidant Use In the Assisted Reproduction Settingmentioning

confidence: 99%

Role of Antioxidants in Assisted Reproductive Techniques

Agarwal

Majzoub

2017

World J Mens Health

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Oxidative stress (OS) has been recognized as a significant cause of suboptimal assisted reproductive outcome. Many of the sperm preparation and manipulation procedures that are necessary in the in vitro environment can result in excessive production of reactive oxygen species (ROS) thereby exposing the gametes and growing embryos to significant oxidative damage. Antioxidants have long been utilized in the management of male subfertility as they can counterbalance the elevated levels of ROS inducing a high state of OS. Few studies have looked into the clinical effectiveness of antioxidants in patients undergoing assisted reproduction. While an overall favorable outcome has been perceived, the specific clinical indication and optimal antioxidant regimen remain unknown. The goal of our review is to explore the sources of ROS in the in vitro environment and provide a clinical scenario-based approach to identify the circumstances where antioxidant supplementation is most beneficial to enhance the outcome of assisted reproduction.

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Sperm motility in the semen analysis affects the outcome of superovulation intrauterine insemination in the treatment of infertile Asian couples with male factor infertility

Cited by 13 publications

References 18 publications

Predictive value of sperm motility before and after preparation for the pregnancy outcomes of intrauterine insemination

Predictive value of sperm motility before and after preparation for the pregnancy outcomes of intrauterine insemination

Temporal Decreases in Sperm Motility: Which Patients Should Have Motility Checked at Both 1 and 2 Hours After Collection?

Role of Antioxidants in Assisted Reproductive Techniques

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