Sperm intrusion into the implantation-stage blastocyst and its potential biological significance
Jayasree Sengupta,
Thomas Kroneis,
Amy M Boddy
et al.
Abstract:The human embryo derives from fusion of oocyte and sperm, undergoes growth and differentiation, resulting in a blastocyst. To initiate implantation, the blastocyst hatches from the zona pellucida, allowing access from external inputs. Modelling of uterine sperm distribution indicates that 200-5000 sperm cells may reach the implantation-stage blastocyst following natural coitus. We show ultrastructural evidence of sperm cells intruding into trophectoderm cells of zona-free blastocysts obtained from the uterus o… Show more
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