Sperm-Hybrid Micromotor for Targeted Drug Delivery

Xu, Haifeng; Medina‐Sánchez, Mariana; Magdanz, Veronika; Schwarz, Lukas; Hebenstreit, Franziska; Schmidt, Oliver G.

doi:10.1021/acsnano.7b06398

Cited by 412 publications

(487 citation statements)

References 66 publications

Supporting

Mentioning

463

Contrasting

Order By: Relevance

“…

Photodynamic therapy (PDT) functions when the light-excited photosensitizers transfer energy to oxygen molecules ( 3 O 2 ) to produce cytotoxic singlet oxygen ( 1 O 2 ) that can effectively kill cells or bacteria. [15] So far, researchers have also explored stimuli-responsive materials, [16][17][18][19] biomimetic materials, [20][21][22] and micro-organisms functionalized with nanomaterials [23] as MNMs to precisely transport cargos of drugs, [16,20,23,24] proteins, [18,22,25] and genes [19] in vitro and/or in vivo. Herein, an enzymatic micromotor based on hollow mesoporous SiO 2 (mSiO 2 ) microspheres is constructed as a mobile and highly efficient photosensitizer platform.

…”

mentioning

confidence: 99%

Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

Zhou

Chen

et al. 2019

Adv Funct Materials

View full text Add to dashboard Cite

Photodynamic therapy (PDT) functions when the light-excited photosensitizers transfer energy to oxygen molecules ( 3 O 2 ) to produce cytotoxic singlet oxygen ( 1 O 2 ) that can effectively kill cells or bacteria. However, the PDT efficacy is often reduced by the limited availability of 3 O 2 surrounding the photosensitizer and extremely short diffusion range of the photoactivated 1 O 2 . Herein, an enzymatic micromotor based on hollow mesoporous SiO 2 (mSiO 2 ) microspheres is constructed as a mobile and highly efficient photosensitizer platform. Carboxylated magnetic nanoparticles are connected with both hollow spheres and 5,10,15,20-tetrakis(4-aminophenyl)porphyrin molecules through covalent linkage between amino and carboxylic groups within a one-step reaction. Due to the intrinsic asymmetry of the mSiO 2 spheres, the micromotors can be propelled by ionic diffusiophoresis induced by the enzymatic decomposition of urea. Via numerical simulation, the self-propulsion mechanism is clarified and the movement direction is identified. By virtue of active self-propulsion, the current system can overcome the long-standing shortcomings of PDT and significantly enhance the PDT efficacy by improving the accessibility of the photosensitizer to 3 O 2 and enlarging the diffusing range of 1 O 2 . Therefore, by proposing a new solution to the bottleneck problems of PDT, this work provides insightful perspectives to the biomedical application of multifunctional micro/nanomotors. applications, including targeted drug delivery, mini-surgery, biochemical sensing, and diagnostics. [13][14][15] In particular, MNMs as active carriers with the capability of cargo loading and controllable motion have great potentials for effective delivery of different types of cargos. [15] So far, researchers have also explored stimuli-responsive materials, [16][17][18][19] biomimetic materials, [20][21][22] and micro-organisms functionalized with nanomaterials [23] as MNMs to precisely transport cargos of drugs, [16,20,23,24] proteins, [18,22,25] and genes [19] in vitro and/or in vivo. Compared with traditional passive delivery, MNMs can perform tasks such as controlled navigation, rapid transportation, and active delivery of payloads to disease sites, and thus have paved way for on demand biomedical cargo transportation. [15] Inspired by these achievements, we envision that self-propelled MNMs can serve as a mobile photosensitizer platform to improve the availability of 3 O 2 as well as the diffusion range of 1 O 2 , which can consequently achieve highly efficient PDT process.

show abstract

“…

Photodynamic therapy (PDT) functions when the light-excited photosensitizers transfer energy to oxygen molecules ( 3 O 2 ) to produce cytotoxic singlet oxygen ( 1 O 2 ) that can effectively kill cells or bacteria. [15] So far, researchers have also explored stimuli-responsive materials, [16][17][18][19] biomimetic materials, [20][21][22] and micro-organisms functionalized with nanomaterials [23] as MNMs to precisely transport cargos of drugs, [16,20,23,24] proteins, [18,22,25] and genes [19] in vitro and/or in vivo. Herein, an enzymatic micromotor based on hollow mesoporous SiO 2 (mSiO 2 ) microspheres is constructed as a mobile and highly efficient photosensitizer platform.

…”

mentioning

confidence: 99%

Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

Zhou

Chen

et al. 2019

Adv Funct Materials

View full text Add to dashboard Cite

Photodynamic therapy (PDT) functions when the light-excited photosensitizers transfer energy to oxygen molecules ( 3 O 2 ) to produce cytotoxic singlet oxygen ( 1 O 2 ) that can effectively kill cells or bacteria. However, the PDT efficacy is often reduced by the limited availability of 3 O 2 surrounding the photosensitizer and extremely short diffusion range of the photoactivated 1 O 2 . Herein, an enzymatic micromotor based on hollow mesoporous SiO 2 (mSiO 2 ) microspheres is constructed as a mobile and highly efficient photosensitizer platform. Carboxylated magnetic nanoparticles are connected with both hollow spheres and 5,10,15,20-tetrakis(4-aminophenyl)porphyrin molecules through covalent linkage between amino and carboxylic groups within a one-step reaction. Due to the intrinsic asymmetry of the mSiO 2 spheres, the micromotors can be propelled by ionic diffusiophoresis induced by the enzymatic decomposition of urea. Via numerical simulation, the self-propulsion mechanism is clarified and the movement direction is identified. By virtue of active self-propulsion, the current system can overcome the long-standing shortcomings of PDT and significantly enhance the PDT efficacy by improving the accessibility of the photosensitizer to 3 O 2 and enlarging the diffusing range of 1 O 2 . Therefore, by proposing a new solution to the bottleneck problems of PDT, this work provides insightful perspectives to the biomedical application of multifunctional micro/nanomotors. applications, including targeted drug delivery, mini-surgery, biochemical sensing, and diagnostics. [13][14][15] In particular, MNMs as active carriers with the capability of cargo loading and controllable motion have great potentials for effective delivery of different types of cargos. [15] So far, researchers have also explored stimuli-responsive materials, [16][17][18][19] biomimetic materials, [20][21][22] and micro-organisms functionalized with nanomaterials [23] as MNMs to precisely transport cargos of drugs, [16,20,23,24] proteins, [18,22,25] and genes [19] in vitro and/or in vivo. Compared with traditional passive delivery, MNMs can perform tasks such as controlled navigation, rapid transportation, and active delivery of payloads to disease sites, and thus have paved way for on demand biomedical cargo transportation. [15] Inspired by these achievements, we envision that self-propelled MNMs can serve as a mobile photosensitizer platform to improve the availability of 3 O 2 as well as the diffusion range of 1 O 2 , which can consequently achieve highly efficient PDT process.

show abstract

“…Magdanz et al [26] and Medina-Sanchez et al [25] reported the use of micromotors to guide or transport motile and immotile sperms to eventually overcome two of the main male infertility problems: oligozoospermia (low sperm count) and asthenozoospermia (poor sperm motility), respectively. In our group, a sperm-hybrid micromotor system was also developed as a new drug-delivery system to potentially treat diseases in the female reproductive tract ( Figure 3D & Table 2) [24,82]. In this work, DOX was loaded into bovine sperms by a co-incubation method.…”

Section: Cells/microorganisms As Propellersmentioning

confidence: 99%

Micro- and nano-motors: the New Generation of Drug Carriers

2018

Self Cite

View full text Add to dashboard Cite

Micro-and nano-motors are emerging as novel drug delivery platforms, offering advantages such as rapid drug transport, high tissue penetration and motion controllability. They can be propelled and/or guided by endogenous (i.e., chemotaxis) or exogenous stimuli (e.g., ultrasound, magnetic fields, light) toward the area of interest. Moreover, such stimuli can be used to trigger the release of a therapeutic payload when the motor reaches certain location in order to improve the drug targeting. In this review article, we highlight medically oriented micro-/nano-motors, in particular the ones created for targeted drug delivery, and discuss their current limitations and possibilities toward in vivo applications. Drug-delivery systems have greatly evolved since 1952, when the first sustained release systems were introduced (see the graphical abstract) [1]. In the 1980s, self-regulated drug release carriers as well as the first drug delivery nanostructures were developed. From then on, research in this field has been focused on improving the targeting and systemic circulation of those carriers as well as to study different nanoparticle-based drug formulations, topics which have been widely reviewed in the literature [2][3][4][5][6][7]. Several nanocarriers (between 5 and 200 nm diameter) have been explored for therapy (e.g. inorganic, polymeric, liposomes, nanocrystals, nanotubes and dendrimers) [8], many of them already approved by the Food and Drug Administration (FDA) to treat, for example, neurovascular diseases, neurological cancers and neurodegenerative maladies [9]. The study of their pharmacokinetics has led to the creation of new carriers with reduced drug dose and protection from efflux or degradation [10]. Most of these nanocarriers include sophisticated surface biofunctionalization and coatings like polyethylene glycol (PEG) [11] or biomimetic modifications, [12] to increase their specificity and circulation time [13]. However, challenges still remain for those carriers such as the improvement of their targeting (currently only about 0.7% -median -of the administrated nanoparticle dose is found to be delivered to a solid tumor [14]), their penetration ability, drug loading capacity and delivery on the subcellular level. Other type of drug carriers are the cellular ones, which have many advantages such Graphical abstract:

show abstract

“…Another strategy employed by some biohybrids and bioinspired microswimmers is the periodical deformation of their propulsion apparatus . This deformation leads to a change in the mobility matrix at each point in time.…”

Section: Fundamentalsmentioning

confidence: 99%

Biohybrid and Bioinspired Magnetic Microswimmers

Bente

Codutti

Bachmann

et al. 2018

Small

115

View full text Add to dashboard Cite

Many motile microorganisms swim and navigate in chemically and mechanically complex environments. These organisms can be functionalized and directly used for applications (biohybrid approach), but also inspire designs for fully synthetic microbots. The most promising designs of biohybrids and bioinspired microswimmers include one or several magnetic components, which lead to sustainable propulsion mechanisms and external controllability. This Review addresses such magnetic microswimmers, which are often studied in view of certain applications, mostly in the biomedical area, but also in the environmental field. First, propulsion systems at the microscale are reviewed and the magnetism of microswimmers is introduced. The review of the magnetic biohybrids and bioinspired microswimmers is structured gradually from mostly biological systems toward purely synthetic approaches. Finally, currently less explored parts of this field ranging from in situ imaging to swarm control are discussed.

show abstract

Sperm-Hybrid Micromotor for Targeted Drug Delivery

Cited by 412 publications

References 66 publications

Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

Enzymatic Micromotors as a Mobile Photosensitizer Platform for Highly Efficient On‐Chip Targeted Antibacteria Photodynamic Therapy

Micro- and nano-motors: the New Generation of Drug Carriers

Biohybrid and Bioinspired Magnetic Microswimmers

Contact Info

Product

Resources

About