Sperm Epigenetics and Its Impact on Male Fertility, Pregnancy Loss, and Somatic Health of Future Offspring

Ibrahaim, Yetunde; Hotaling, Jim

doi:10.1055/s-0039-1688453

Cited by 8 publications

(8 citation statements)

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“…Epigenetics has been hypothesized as a potential mechanism through which paternal health, including chronic disease and age, can impact offspring health (23,24). Preclinical models have begun to elucidate these underlying mechanisms contributing to paternal influence (25).…”

Section: Discussionmentioning

confidence: 99%

Association of preconception paternal health on perinatal outcomes: analysis of U.S. claims data

Kasman

Zhang

et al. 2020

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Association of preconception paternal health on perinatal outcomes: analysis of U.S. claims data

Kasman

Zhang

et al. 2020

Fertility and Sterility

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“…One proposed mechanism by which paternal health can impact offspring health is through epigenetics, the activation or deactivation of genes without alterations of the DNA sequence. 21,22 There is a growing body of evidence that paternal exposures and comorbidities can imprint on the health of offspring through alterations in the epigenetic profile of spermatozoa. Animal models have shown that environmental changes such as alterations in diet can produce changes to methylation patterns in offspring DNA.…”

Section: Discussionmentioning

confidence: 99%

The association of preconception paternal metabolic syndrome on early childhood emergency department visits and hospitalizations

Chen

Zhang

et al. 2023

Andrology

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Background Increasing preconception paternal comorbidity has been associated with adverse pregnancy outcomes. However, whether the father's health impacts the child after birth is uncertain. Objectives In the present study, we examined the association of preconception paternal metabolic syndrome status with childhood emergency department visits and hospitalizations. Materials and Methods This is a longitudinal cohort study of children (295,355 boys and 278,735 girls) born to linked pairs of fathers and mothers in the United States between 2009 and 2016 within the IBM MarketScan Research database. Associations between paternal and maternal metabolic syndrome component diagnoses and subsequent hospitalizations and emergency department visits for offspring within the first 2 years of life were determined. Results Note that, 35.5% (203,617/574,090) of children had at least one emergency room visit and 6.1% (35,141/574,090) of children had an inpatient admission. After adjustment, the odds of inpatient admission and emergency department visits increased in a dose‐dependent fashion among fathers with higher comorbidities. Similar trends were seen for emergency department visit utilization. Discussion and Conclusion Increasing paternal preconception comorbidity is associated with a higher risk that a child requires the emergency department and inpatient care in the first years of life. An opportunity exists to engage men in preconception counseling to optimize their and their offspring's health.

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“…Genomic and epigenomic analyses of sperm DNA are increasingly necessary techniques, with broad applications that include fertility diagnostics, forensic analyses and basic research [1,2]. Additionally, male infertility is a well-recognized concern that contributes to failed pregnancies in humans and agricultural animals [3].…”

Section: Methods Summarymentioning

confidence: 99%

Simple Workflow for Genome and Methylation Analyses of Ejaculated Bovine Spermatozoa with Low Sperm Input

2020

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We developed a simplified workflow of gDNA extraction from ejaculated bovine sperm using a low total number of sperm and a short time frame that yields high-quality DNA suitable for downstream methylation and genome analyses. These techniques have broad implications in human biomedical sciences and agriculture, including clinical diagnoses of infertility, the identification of single-nucleotide polymorphisms and aberrant methylation patterns that can impact fertility, lower embryo development and contribute to heritable disease. The methods described here provide a reliable, simplistic approach for analyzing both the genomic and epigenomic status of whole sperm ejaculates that can be adapted for laboratory diagnostics, clinical reproductive practice and basic research.

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Sperm Epigenetics and Its Impact on Male Fertility, Pregnancy Loss, and Somatic Health of Future Offspring

Cited by 8 publications

References 0 publications

Association of preconception paternal health on perinatal outcomes: analysis of U.S. claims data

Association of preconception paternal health on perinatal outcomes: analysis of U.S. claims data

The association of preconception paternal metabolic syndrome on early childhood emergency department visits and hospitalizations

Simple Workflow for Genome and Methylation Analyses of Ejaculated Bovine Spermatozoa with Low Sperm Input

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