Sperm donor lifestyle survey: modifiable risk factors for potential sperm donors

Huang, Chuan; Liu, Qian; Wang, Zhongwei; Zhou, Wen-Jun; Huang, Zeng-Hui; Ji, Xi-Ren; Luo, Xue-Feng; Tang, Yu-Ling; Fan, Lu; Zhu, Wenbing

doi:10.1007/s10815-021-02322-x

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…The differences might result from racial and ethnic differences, representing various gene phenotypes and lifestyles that may affect semen quality. 33 The present findings were coincident with our previous results 22 ; the participants we recruited in this study had similar ethnicity and residence and came from the similar population. In addition, our previous study evaluated the semen quality with 5 conventional and kinematic parameters; however, these parameters were insufficient given that sperm morphology and sperm DNA integrity, essential assessors of semen quality and fertilization potential, were not added in the study.…”

Section: Discussionsupporting

confidence: 92%

“…However, in China, our previous study found that FA exposure in males was associated with decreased sperm motility. The differences might result from racial and ethnic differences, representing various gene phenotypes and lifestyles that may affect semen quality . The present findings were coincident with our previous results; the participants we recruited in this study had similar ethnicity and residence and came from the similar population.…”

Section: Discussionsupporting

confidence: 91%

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Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

Wang

Yang

et al. 2022

JAMA Netw Open

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IMPORTANCEThe potential effects of long-term occupational exposure to formaldehyde (FA) on human semen quality is not clear. OBJECTIVE To assess whether long-term occupational exposure to FA is associated with semen quality. DESIGN, SETTING, AND PARTICIPANTS This population-based cohort study was conducted fromJune 1 to June 30, 2021, in Xi'an, China. Participants were adults aged 23 to 40 years who had lived in the study area for 24 months or longer. Data analysis was performed from September 1 to October 1, 2021.EXPOSURES Long-term occupational exposure to FA was measured using a formaldehyde detector, and the FA exposure index (FEI) was calculated as follows: FEI = final concentration of FA (mg/m 3 ) × work time during a workday (hour) × cumulative workdays (year). MAIN OUTCOMES AND MEASURESSemen samples were collected by masturbation after 3 to 7 days of abstinence and were then assessed by the computer-automated semen analysis system, Baso-Papanicolaou staining, and sperm-chromatin structure assay. RESULTSA total of 205 men (mean [SD] age, 29.49 [3.64] years), with 124 individuals in the FA exposure group (mean [SD] FEI , 73.72 [54.86]) and 81 age-matched controls, were included in the final analysis. Long-term personal occupational exposure to FA was significantly associated with poor semen quality. Specifically, a 1-unit increase in FEI was associated with a change of −0.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

Wang

Yang

et al. 2022

JAMA Netw Open

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“…Similarly, inadequate sleep duration and poor sleep quality are potential risk factors for reduced semen quality. Several studies have investigated the relationship between sleep disorders and semen quality in men, however, the results have been inconsistent ( Jensen et al, 2013 ; Li et al, 2013 ; Liu et al, 2017 ; Du et al, 2020b ; Huang et al, 2021 ). This study collects current research to investigate the relationship between nocturnal sleep disorders and semen quality parameters in men and analyses gene expression in non-obstructive azoospermia (NOA) patients to explore the impact of sleep disorders and biological clock disorder on male reproductive health.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sleep Disorders and Circadian Rhythm Changes on Male Reproductive Health: A Systematic Review and Meta-analysis

et al. 2022

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Objectives: The purpose of this study was to elucidate the relationship between sleep disorders and male reproductive health, and to explore the underlying mechanisms via a systematic review and meta-analysis.Methods: PubMed, Embase, The Cochrane library, Web of Science, Scopus databases were searched to collect clinical research on the effects of sleep disorders on male semen parameters from inception to February 24, 2022. RevMan 5.4 was used for meta-statistical analysis. Stata16 software was used to detect publication bias.Results: The results of meta-analysis showed that sleep disorders were associated with reduced total sperm count (mean difference (MD) = −27.91, 95% CI = (−37.82, −18.01), p < 0.001), reduced sperm concentration (MD = −5.16, 95% CI = (−9.67, −0.65), p = 0.02), reduced progressive motility (MD = −2.94, 95% CI = (−5.28, −0.59), p = 0.01), and reduced normal morphology (MD = −0.52, 95% CI = (−0.80, −0.24), p < 0.001). However, there is no significant association between sleep disorders and semen volume/reproductive hormones. Further bioinformatics mining revealed that related clock genes (PER1, PER2, CRY2, NR1D1 and NPAS2) were down-regulated in non-obstructive azoospermia patients.Conclusion: In conclusion, current evidence suggests that sleep disorders have a negative impact on male reproductive health, and its underlying mechanism may be related to circadian rhythm disorders. However, the relationship between sleep disorders and reproductive hormone levels has not been found. Due to the limited number and quality of included studies, the above findings need to be validated by more high-quality studies.

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Association of diet and lifestyle factors with semen quality in male partners of Chinese couples preparing for pregnancy

Mai,

Ke,

Zheng

et al. 2023

Reprod Health

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Background Semen quality significantly influences conception, and its preservation is crucial for couples seeking pregnancy. We investigated dietary and lifestyle risk factors impacting semen quality. Methods A total of 466 males from the Guangzhou Women and Children’s Medical Center’s pre-pregnancy consultation clinic were recruited between January 2021 and March 2023 for inclusion. Semen analysis was performed, and diet and lifestyle data were gathered via questionnaire. Logistic regression was utilized to examine the link between diet, lifestyle variables, and semen quality. Results Smoking worsened progressive sperm motility (38.0% vs. 36.0%, t = 2.262; P = 0.049). Alcohol consumption impaired progressive motility (40.5 ± 17.8% vs. 34.7 ± 16.1%, t = 3.396; P < 0.001) and total motility (56.0% vs. 64.0%; P = 0.001). Using plastic beverage bottles for oil or seasonings lowered sperm concentrations (40.4% vs. 59.0% vs. 65.5%; P = 0.032). A sweet diet correlated with higher total sperm motility (55.0% vs. 60.0%, 62.0% vs. 63.2%; P = 0.017). Higher milk product intake improved sperm concentration (41.6106vs. 63.7106 vs. 66.1*106; P = 0.021) and motility (54.5% vs. 56.0% vs. 63.0%; P = 0.033). More frequent egg consumption increased semen volume (3.1 mL vs. 3.8 mL vs. 4.0 mL; P = 0.038). Roughage intake enhanced sperm concentration (160.8106 vs. 224.6106; P = 0.027), and adequate sleep improved progressive sperm motility rate (35.4% ± 18.2% vs. 40.2 ± 16.3%, F = 3.747; P = 0.024) and total motility (52.7% vs. 61.5%; P = 0.013). The regression model showed that using plastic containers for condiments was a protective factor for semen volume (OR: 0.12; CI 0.03–0.55; P = 0.006), sperm concentration (OR: 0.001, CI 0.00–0.30; P = 0.012), and count (OR: 0.12, CI 0.03–0.48; P = 0.003). Milk and egg consumption were also protective for semen volume (OR: 0.18, CI 0.06–0.51; P = 0.001 and OR: 0.11, CI 0.03–0.55; P = 0.006, respectively), while sufficient sleep benefitted total sperm motility (OR: 0.47, CI 0.24–0.95; P = 0.034). Conclusions Smoking and drinking, type of condiment container, diet preference, sleep duration, and milk, roughage, and egg consumption may reduce semen quality.

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Sperm donor lifestyle survey: modifiable risk factors for potential sperm donors

Cited by 3 publications

References 24 publications

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

Effects of Sleep Disorders and Circadian Rhythm Changes on Male Reproductive Health: A Systematic Review and Meta-analysis

Association of diet and lifestyle factors with semen quality in male partners of Chinese couples preparing for pregnancy

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