Sperm DNA fragmentation negatively correlates with velocity and fertilization rates but might not affect pregnancy rates

Detection of DNA fragmentation and meiotic segregation in human with isolated teratozoospermia

“…This observation is in agreement with the reports of several recent studies; which indicated an increased percentage of spermatozoa with damaged DNA in the ejaculates of infertile men with abnormal semen parameters compared with normozoospermics controls [26][27][28]. A significant association between sperm morphology and sperm DNA damage was identified in our study.…”

Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success

“…In agreement with previous studies (41)(42)(43)(44)(45)(46)(47)(48), we report a significant decrease in fertilization rate as DNA damage of both native semen and DGC sperm increased. Sperm DNA damage is associated with abnormal chromatin packing indicated by alterations in protamine content (49), therefore the reduction in fertilization may be due to a failure of sperm DNA decondensation (50,51).…”

The association between polypronucleate zygote formation with certain motion characteristics of sperm and IVF outcome

“…The high rate of PPN was associated with rapid progressive sperm motile characteristics. In our previous study, sperm velocity parameters have been negatively correlated with sperm DNA fragmentation rate [28]. The result of our present study (Table 3 and 4) would suggest that the rate of PPN was closely related with quality and quantity of rapid progressive sperm in seminal plasma and might be viewed as a sign of high fertilization potential.…”