Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor

Marchlewska, Katarzyna; Filipiak, Eliza; Walczak-Jędrzejowska, Renata; Oszukowska, Elżbieta; Sobkiewicz, S; Wójt, Małgorzata; Chmiel, Jacek; Kula, Krzysztof; Słowikowska-Hilczer, Jolanta

doi:10.1155/2016/7893961

Cited by 13 publications

(11 citation statements)

References 39 publications

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“…As forother strengths of our study, we wanted to highlighted some facts. Despite that our control group does not contain only men with proven fertile status, our results of SDF assessment were in agreement with other researchers, who have shown that clinically significant threshold to discriminated men with proven fertility from infertile men is approximately 15-20% [18,19,32,33]. Moreover, all participants both normozoospermic volunteers and diagnosed infertile patients came to the same laboratory and the analysis of their semen was carried out in exactly the same way.…”

Section: Limitations and Strengths Of The Studysupporting

confidence: 89%

“…Presented above results are in agreement with data from other authors. Marchlewska et al [19] reported that men from infertile couples had 28.00% spermatozoa with SDF. Majzoub et al [20] revealed significant differences in SDF between infertile and fertile men (mean: 27.60 ± 1.02% vs 15.68 ± 0.92%).…”

Section: Sdf Measured By the Halosperm Test Reflects Male Fertility Pmentioning

confidence: 99%

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The higher risk for sperm DNA damage in infertile men

et al. 2019

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Objectives: Supplementary assays are needed for determination of relationships between sperm biomarkers and fertility potential. Therefore, our research was designed to determine the extent of sperm DNA fragmentation (SDF) and establish a discriminating threshold of SDF for fertility potential. Material and methods: Semen characteristics were evaluated according to World Health Organization recommendations, and SDF was assessed by sperm chromatin dispersion test on ejaculated spermatozoa from infertile and healthy normozoospermic men. Results: A higher proportion of SDF was noted in infertile men (median 23.00%) than normozoospermic (median 14.00%). Significantly less subjects (17.03%) with low SDF level (≤ 15%) and more (35.17%) with high SDF level (> 30%) were found for the infertile group vs the normooospermic (57.90% and 5.26%, respectively). Infertile group had significantly lower odds ratio (OR) for having a low SDF level (OR: 0.1493) and higher OR for having a high SDF level (OR: 9.7627). Receiver operating characteristic analysis [area under curve (AUC) = 0.785] revealed that 20% SDF is predictive value for discriminating between infertile and normozoospermic subjects. SDF was negatively correlated with the sperm number, morphology, progressive motility and vitality but positively with the teratozoospermia index. Conclusions: Our study demonstrates: (1) a significant difference in the extent of SDF and in the risk for having damaged sperm DNA between infertile and normozoospermic men, (2) > 20% SDF has negative predictive value for fertility potential, (3) coexistence of abnormal standard sperm parameters with sperm chromatin damages. Therefore, SDF should be considered as a highly valuable indicator of male fertility potential.

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Section: Limitations and Strengths Of The Studysupporting

confidence: 89%

Section: Sdf Measured By the Halosperm Test Reflects Male Fertility Pmentioning

confidence: 99%

The higher risk for sperm DNA damage in infertile men

et al. 2019

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“…DNA fragmentation is a marker of DNA damage, but also a biomarker of fertility, which is thought to be superior to conventional semen markers in predicting fertility potential. Raised DNA fragmentation, as quantitated by the DNA fragmentation index (DFI), is associated with decreased conception rates and early pregnancy loss . Paoli et al found that after chemotherapy DFI increases significantly 3 months post chemotherapy.…”

Section: Testicular Cancer Treatment and Infertilitymentioning

confidence: 99%

Fertility managment in testicular cancer: the need to establish a standardized and evidence‐based patient‐centric pathway

et al. 2018

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The underutilisation of semen analysis and sperm cryopreservation results in the failure to identify the azoospermic or severely oligozoospermic patient at diagnosis who may benefit from fertility-preserving procedures, for example, onco-microTESE at the time of orchidectomy. Fertility preservation and counselling needs to be broached earlier in the TC treatment pathway and made a greater priority. Given the advances in treatment, more patients with TC are surviving and looking to return to a normal life. Preserving their future fertility plays an important role in achieving this.

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“…The regional structure of assets and the number of Islamic banks [18] As we mentioned above, the profitability of Islamic banks is lower than that of traditional banks. Moreover, it is uneven, as Islamic banks in Asian, African and Gulf countries demonstrate relatively higher profitability [19,20].…”

Section: Fig 2 Expected Islamic Assets Globallymentioning

confidence: 99%

Islamic Banking: Modern Trends and Problems

Jusupova¹,

Kokh²,

Nikonova³

2018

Proceedings of the International Conference "Economy in the Modern World" (ICEMW 2018)

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Islamic Finance is a financial system based on Islamic principles of transactions, offering alternatives to traditional forms of ethical and social financial behavior. Islamic banks started a rapid growth after the global financial crisis of 2008, showing greater resilience to risk than traditional banking institutions. Islamic banking is a normative concept that can be defined as banking compatible with the system of Islamic values. Today there are more than 300 Islamic banks in the world. Despite the significant growth observed in the assets of Islamic banks, their share in the global financial market is relatively small. A significant trend is the active penetration of Islamic banks into the national economies of the developed and developing countries, especially in the economies of countries that are seriously underfunded. The article describes the main trends, as well as the problems that prevent the expansion of Islamic banking in the modern economy. The authors conclude that Islamic banking faces such restrictions and limitations as: not relevant national banking legislation, lack of necessary financial infrastructure, low level of individual and corporative financial literacy, lack of information about Islamic financial products.

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Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor

Cited by 13 publications

References 39 publications

The higher risk for sperm DNA damage in infertile men

The higher risk for sperm DNA damage in infertile men

Fertility managment in testicular cancer: the need to establish a standardized and evidence‐based patient‐centric pathway

Islamic Banking: Modern Trends and Problems

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