Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers

Hsu, Ping-Chi; Chen, I-Yueh; Pan, Chih-Hong; K, Wu; Pan, Min‐Hsiung; Chen, Jenq-Renn; Chen, Chun‐Jung; Chang-Chien, Guo-Ping; Hsu, Chang-Hung; Liu, Chiu-Shong; Wu, Ming-Tsang

doi:10.1007/s00420-005-0066-3

Cited by 62 publications

(44 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although 1-OHP is the most commonly used indicator of PAHs exposure in many previously reported studies, some studies suggest that it may not represent the numerous PAHs metabolites [22]. However, in the study by Hsu et al (2006) [28] assessing the sperm damage after exposure to polycyclic aromatic hydrocarbons the authors noticed that 1-OHP can be used as a biomarker predicting sperm dysfunction [28]. Most of the studies which examine the association between exposure to PAHs and sperm quality indicate that 1-OHP may affect male semen quality even at non-occupational exposure levels [24,25,27,41].…”

Section: Ijomeh 2013;26(5) 797mentioning

confidence: 94%

“…One cohort study from Selevan et al (2000), [24] reports an association between air pollution episodes of elevated PAHs and the increased asthenospermia, abnormal morphology, and abnormal chromatin in human sperm. In the study by Hsu et al (2006) [28] among coke-oven workers from a steel plant in southern Taiwan occupationally exposed to high levels of PAHs, the number of workers with oligospermia and the percentage of abnormal sperm morphology was significantly greater in topside oven workers than in the side-oven workers. [28].…”

Section: Ijomeh 2013;26(5) 797mentioning

confidence: 94%

“…In the study by Hsu et al (2006) [28] among coke-oven workers from a steel plant in southern Taiwan occupationally exposed to high levels of PAHs, the number of workers with oligospermia and the percentage of abnormal sperm morphology was significantly greater in topside oven workers than in the side-oven workers. [28]. The later two studies performed among the same group of Taiwanese workers found that urinary 1-OHP does not significantly correlate with semen quality; however, PAHs with heavy molecular weight, e.g., benzo(g,h,i)perylene and benzo(k)fluoranthene, negatively correlate with morphology and motility of sperm cells (p = 0.02 and 0.002, p = 0.04 and 0.04, respectively) [39].…”

Section: Ijomeh 2013;26(5) 797mentioning

confidence: 94%

See 2 more Smart Citations

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Jurewicz¹,

Radwan²,

Sobala³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Objectives: Growing evidence supports the reproductive and developmental toxicity of polycyclic aromatic hydrocarbons (PAHs) from prenatal and postnatal exposure, but the results of epidemiological studies regarding harmful effects of PAHs exposure on male reproductive system still remain limited and inconclusive. The aim of the present study was to investigate the relationship between 1-hydroxypyrene, a biomarker of polycyclic aromatic hydrocarbons exposure and semen quality. Materials and Methods:The study population consisted of 277 men attending an infertility clinic for diagnostic purposes and having normal semen concentration of 20-300 mln/ml or slight oligozoospermia (semen concentration: 15-20 mln/ml) (WHO 1999). All the men were healthy and under 45 years of age. All participants were interviewed and provided a semen sample. The interview included questions concerning demographics, socio-economic status, medical history related to past diseases which may have an impact on semen quality, lifestyle factors and occupational information. Concentrations of 1-hydroxypyrene (1-OHP) in the urine samples were analyzed using high performance liquid chromatography (HPLC). Results: A positive association was found between the level of 1-OHP in urine and sperm neck abnormalities as well as the percentage of static sperm cells (p = 0.001, p = 0.018, respectively). Additionally, exposure to PAHs measured by 1-OHP in urine decreased semen volume and the percentage of motile sperm cells (p = 0.014, p = 0.0001, respectively). Conclusions: Presented findings indicate that the environmental level of PAHs exposure adversely affects male semen quality. The future large-scale studies should incorporate different biomarkers to generate a more accurate and full assessment of the effects of PAHs exposure on male fertility.

show abstract

Section: Ijomeh 2013;26(5) 797mentioning

confidence: 94%

Section: Ijomeh 2013;26(5) 797mentioning

confidence: 94%

Section: Ijomeh 2013;26(5) 797mentioning

confidence: 94%

See 1 more Smart Citation

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Jurewicz¹,

Radwan²,

Sobala³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

show abstract

“…[37][38][39] Among xenoestrogens, phthalates are ubiquitous in human life. Hsu et al 40 and Han et al 41 reported that polycyclic aromatic hydrocarbons are associated with DNA damages. Recent studies have demonstrated that not only androgens but also oestrogens have an important role in male reproduction.…”

Section: Contribution Of Environmental Factorsmentioning

confidence: 99%

Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

Geoffroy-Siraudin¹,

Loundou²,

Romain³

et al. 2012

Asian J Androl

View full text Add to dashboard Cite

Semen from 10 932 male partners of infertile couples was analysed and sperm parameter trends were evaluated at the Reproduction Biology Laboratory of the University Hospital of Marseille (France) between 1988 and 2007. After 3-6 days of abstinence, semen samples were collected. Measurements of seminal fluid volume, pH, sperm concentration, total sperm count, motility and detailed morphology of spermatozoa were performed. Sperm parameters were analysed on the entire population and in men with normal total numeration (o40 million per ejaculate). The whole population demonstrated declining trends in sperm concentration (1.5% per year), total sperm count (1.6% per year), total motility (0.4% per year), rapid motility (5.5% per year) and normal morphology (2.2% per year). In the group of selected samples with total normal sperm count, the same trends of sperm quality deterioration with time were observed. Our results clearly indicate that the quality of semen decreased in this population over the study period. Keywords: environment; male infertility; regional differences; semen quality; sperm parameters INTRODUCTION Numerous studies suggest a decline in semen quality in some parts of the world. 1-8 By contrast, other studies have shown no evidence of deteriorating semen quality. 9-16 Some studies concern infertile couples, while others analyse normal sperm parameters. Thus, a worldwide decreasing trend in semen parameter values can be neither confirmed nor rejected. 17 It was recently reported that fecundity is affected by this decrease. 18,19 It was speculated that decreasing sperm parameters are in response to adverse environmental factors. Nevertheless, the observed discrepancies between studies suggest regional differences in semen quality. [20][21][22] Variations in environmental factors, industrial pollution and/or lifestyle could explain these discrepancies. A large number of environmental factors can pollute air, drinking water and food. This can directly alter the male gonad by blood-testis barrier disruption and cellular toxicity, or disrupt androgen biosynthesis and action. Among these environmental factors, oestrogenic or anti-androgenic endocrine disrupting compounds inhibit critical cellular process controlling steroidogenesis in Leydig cells and androgen binding to the androgen receptor. 23 It has been hypothesized that endocrine disrupting compounds play a major role in the aetiology of increased incidence of testicular dysgenesis syndrome which gathers decreased quality of semen, cryptorchidism, hypospadias and testicular cancer. 24 Chemicals with hormone-like activity can also

show abstract

“…Polycyclic aromatic hydrocarbons (PAHs) are common toxic compounds generated from coal combustion during steel processing. Several PAH compounds have been reported to impair the reproductive capacity of males, including decreased semen quality in terms of concentration, motility and vitality [1][2][3]. Cellular deoxyribonucleic acid (DNA) has been suggested as a target in the subjects exposed to PAHs.…”

Section: Introductionmentioning

confidence: 99%

Sperm quality and DNA integrity of coke oven workers exposed to polycyclic aromatic hydrocarbons

Jeng

Pan

Chao

et al. 2016

Int J Occup Med Environ Health

Self Cite

View full text Add to dashboard Cite

International Journal of Occupational Medicine and EnvironmentalThe objective of this study was to assess sperm quality and deoxyribonucleic acid (DNA) integrity of coke oven workers exposed to polycyclic aromatic hydrocarbons (PAHs) as compared to control subjects. Material and Methods:The coke oven workers (N = 52) and administrative staff (N = 35) of a steel plant served as the exposed and control groups, respectively. Exposure to PAHs was assessed by measuring 1-hydroxypyren. Analysis of sperm quality (concentration, motility, vitality, and morphology) was performed simultaneously with sperm DNA integrity analysis, including DNA fragmentation, denaturation, bulky DNA adducts, and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo). A questionnaire was conducted to collect demographic and potential confounding data. Results: The coke oven workers had lower percentages of sperm motility, vitality and normal morphology than the control group, but the difference was not significant. For DNA integrity, the coke oven workers had significantly higher concentrations of bulky DNA adducts and 8-oxo-dGuo than the control subjects (p = 0.009 and p = 0.048, respectively). However, DNA fragmentation percentages did not significantly increase as compared to those in the subjects from the control group (p = 0.232). There was no correlation between sperm quality parameters and DNA integrity indicators. Conclusions: Occupational exposure of the coke oven workers to PAHs was associated with decreased sperm DNA integrity. Int J Occup Med Environ Health 2016;29(6):915-926

show abstract

Sperm DNA damage correlates with polycyclic aromatic hydrocarbons biomarker in coke-oven workers

Abstract: A potential risk of sperm dysfunction should be considered for workers occupationally exposed to high levels of PAHs. Cigarette smoking may aggravate this risk. Urinary 1-OHP can be used as a biomarker predicting sperm dysfunction.

Cited by 62 publications

References 45 publications

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Association between a biomarker of exposure to polycyclic aromatic hydrocarbons and semen quality

Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

Sperm quality and DNA integrity of coke oven workers exposed to polycyclic aromatic hydrocarbons

Contact Info

Product

Resources

About