Sperm concentration in Latvian military conscripts as compared with other countries in the Nordic–Baltic area

Tsarev, Igor; Gagonin, Valerij; Giwercman, Aleksander; Ērenpreiss, Juris

doi:10.1111/j.1365-2605.2005.00523.x

Cited by 29 publications

(31 citation statements)

References 36 publications

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“…The positive significant correlation found between testicular cancer and cryptorchidism among 'high-quality matching coverage' registries outside Europe is consistent with studies showing a markedly higher Jørgensen et al, 2002;Punab et al, 2002;Richthoff et al, 2002;Tsarev et al, 2005;Paasch et al, 2008;Fernandez et al, 2012. risk of testicular cancer is in men with a history of cryptorchidism (Swerdlow et al, 1997;Schnack et al, 2010). Orchidopexy (the surgical displacement of the testes to the scrotum of cryptorchid boys) was suggested to reduce the risk of testicular cancer in one study (Pettersson et al, 2007) but this was not confirmed in another larger study (Myrup et al, 2007).…”

Section: Discussionsupporting

confidence: 62%

“…We did not use data from studies performed among fertile men (partners of pregnant women) as they do not reflect the situation Geographical analysis of male reproductive disorders in general population: infertile men and subfertile men are underrepresented or not included in those studies and thus the results of semen characteristics are inevitably higher. General population data were available for nine European cities: Turku, Finland; Oslo, Norway; Copenhagen, Denmark; Tartu, Estonia (Jørgensen et al, 2002), Malmö , Sweden (Richthoff et al, 2002); Riga, Latvia (Tsarev et al, 2005); Kaunas, Lithuania ; Almeria, Spain (Fernandez et al, 2012) and Leipzig, Germany (Paasch et al, 2008).…”

Section: Sperm Quality Datamentioning

confidence: 99%

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International geographic correlation study of the prevalence of disorders of male reproductive health

et al. 2013

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what is known already: Some associations between these outcomes have been shown in studies focusing on individuals and mainly in Nordic European countries. These associations, together with histological evidence of a dysgenesis pattern in testicular tissue specimens, have generated the concept of the existence of a 'testicular dysgenesis syndrome' originating in utero. study design, size, duration: This is a geographical correlation study using cancer, malformations rates and sperm quality data collected between the years 1998 and 2005.participants/materials, setting, methods: Incidence rates of testicular cancer were extracted from International Agency for Research on Cancer registries and Globocan, while cryptorchidism and hypospadias prevalence rates were obtained from EUROCAT and International Clearinghouse for Birth Defects Surveillance and Research registries. Sperm concentration data were extracted from recent studies using standardized methodology. A total of 39 registries and 9 sperm studies were selected. Non-parametric Spearman correlation tests were used to test the association between these four disorders. Correlations were computed for all registries together, for registries with high-quality matching coverage only and by continents. Sensitivity analyses were also conducted using data from prospective clinical studies to take into account potential bias related mainly to ascertainment of malformation rates.main results and the role of chance: We found positive correlations between testicular cancer and hypospadias (r ¼ 0.32, P ¼ 0.05) and between hypospadias and cryptorchidism (r ¼ 0.70, P ¼ 0.008). Stronger correlations were observed when using registries with high-quality matching coverage. Among these registries, differences between Europe and the rest of the world appeared (the positive correlation between testicular cancer and cryptorchidism was stronger outside Europe, r ¼ 0.83, P ¼ 0.01 compared with 0.40, P ¼ 0.60 for European registries). A negative correlation between testicular cancer and sperm concentration was observed (r ¼ 20.88, P ¼ 0.002). These correlations support our initial hypothesis but remain only suggestive due to the intrinsic limitations in the study design (i.e. geographical correlation study) and do not allow causal inference.limitations, reasons for caution: Differences in the ascertainment of malformations rates (definition, length of follow-up) make the international comparison difficult. The small number of registries for some conditions (cryptorchidism) or of studies (for sperm quality) and the absence of information about major risk factors such as ethnicity and socioeconomic status in the registries are also limitations.wider implications of the findings: Our findings are in agreement with results of studies focusing on individuals and suggest that shared risk factors are present in the populations studied. † These authors contributed equally to this work.

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Section: Discussionsupporting

confidence: 62%

Section: Sperm Quality Datamentioning

confidence: 99%

International geographic correlation study of the prevalence of disorders of male reproductive health

et al. 2013

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“…There are two publications of investigations performed in 1996 -1997 describing the reproductive health of young Lithuanian men separately from Estonians (8), and Latvian men (9). Even from this study of 226 young Lithuanians, we noticed some differences of reproductive parameters between Lithuania and Estonia, but we failed to explain these differences.…”

Section: Institute Of Endocrinology Lithuanian University Of Health contrasting

confidence: 59%

“…Possible ethnic differences in sperm concentration were observed in Latvia (9). Only sperm analysis was published, without hormone investigation.…”

Section: Institute Of Endocrinology Lithuanian University Of Health mentioning

confidence: 97%

Male Reproductive Capacity, Evaluated by Testis Volume, Sperm Quality and Reproductive Hormones as an Ehnic Characteristic of the Population

Matulevičius¹

2014

Acta Endo (Buc)

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Lithuanian's male sperm quality was found to be much better as compared with other centres. The highest values of Kaunas young males were observed in total testicular volume, total sperm count, estradiol and SHBG. Parameters much higher than in other centres were sperm volume, normal morphology, sperm concentration, total motility, level of inhibin B and LH. These parameters are important for overall reproductive capacity of Lithuanians. Sperm quality and high spermatogenesis regulating hormone concentration may be considered as ethnic sign of reproductive capacity of a population.

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“…The Latvian patient group consisted of 92 men with oligoasthenoteratozoospermia, which was defined as low sperm motility (progressive sperm motility <20%), low sperm concentration (<15 million/mL), and a low percentage of sperm with normal morphology (<4%). One control group consisted of 187 young men (age, 18-25 years) from the Latvian general population with normal semen quality and unknown fertility, for whom the collection criteria were described previously [7] . The other control group consisted of 200 men, randomly selected from the Latvian National Genome Database known to have 5 children; hence, these men were proven fertile, but had unknown semen quality.…”

Section: Patientsmentioning

confidence: 99%

A New Baltic Population-Specific Human Genetic Marker in the PMCA4 Gene

Stavusis

Inashkina²,

Lāce³

et al. 2016

Hum Hered

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Objectives: The PMCA gene family consists of 4 genes and at least 21 splice variants; among these, the Ca²⁺ ATPase 4 (PMCA4) gene encodes a plasma membrane protein abundantly expressed in several tissues, including the kidney, heart, and sperm. Knockout of PMCA4 causes infertility due to immotile sperm in mouse models. We therefore investigated variants in this gene for potential association with infertility in groups of Estonian (n = 191) and Latvian (n = 92) men with reduced sperm motility. Methods: All exons, exon-intron boundaries, 5′ and 3′ untranslated regions, and the promoter region of the PMCA4 gene were analysed by direct sequencing for a group of Estonian infertile men. Genotyping of guanine and adenine alleles of rs147729934 was performed, using a custom-designed TaqMan® probe for a group of Latvian infertile men as well as additional groups from Latvia and several groups of people with proven ethnicity from the Baltic region. Results: Although we did not identify any significant associations between variants in the gene and infertility, our results indicated that in all studied Latvian and Estonian groups the adenine allele of the variant rs147729934 was present at a higher frequency than expected. Analysis of additional samples indicated that the adenine allele of rs147729934 likely originated once in the modern-day Baltic or western Russia area, as the frequency of the minor adenine allele observed in this region is remarkably higher than that in the general European population. Conclusions: Our results revealed no significant difference in frequencies of genetic variants in PMCA4 gene between men with normal and those with reduced sperm motility. The adenine allele of the variant rs147729934 is potentially an informative tool for future population studies concerning ancient Baltic and Finno-Ugric history.

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Sperm concentration in Latvian military conscripts as compared with other countries in the Nordic–Baltic area

Cited by 29 publications

References 36 publications

International geographic correlation study of the prevalence of disorders of male reproductive health

International geographic correlation study of the prevalence of disorders of male reproductive health

Male Reproductive Capacity, Evaluated by Testis Volume, Sperm Quality and Reproductive Hormones as an Ehnic Characteristic of the Population

A New Baltic Population-Specific Human Genetic Marker in the PMCA4 Gene

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