Sperm Chromosomal Abnormalities In Patients With Unexplained Recurrent Abortions

Al-Hassan, Saad; Hellani, Ali; Al-Shahrani, A; Aldeery, Meshael; Jaroudi, Kamal; Coşkun, Serdar

doi:10.1080/014850190518062

Cited by 30 publications

(24 citation statements)

References 38 publications

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“…A post-embryo transfer effect is also supported by studies that have reported an increase in sperm aneuploidy in men from couples with a history of RM of unknown cause (Rubio et al, 1999;Carrell et al, 2003;Al-Hassan et al, 2005), with a similar mechanism impairing implantation, leading to cycle failure and early pregnancy loss.…”

Section: Discussionsupporting

confidence: 54%

The role of sperm aneuploidy as a predictor of the success of intracytoplasmic sperm injection?

et al. 2007

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BACKGROUND: We present the first powered prospective study to assess whether sperm aneuploidy can predict the outcome of ICSI. METHODS: Our null hypothesis was that aneuploidy rates (AR) are identical in men who achieve successful (Group A) and unsuccessful (Group B) ICSI outcome. A power calculation yielded a sample number of 56 to achieve 80% power to reject our hypothesis at the 5% significance level. Samples for testing were obtained on the day of embryo transfer and tests were performed on raw pre-preparation samples. Sperm AR of chromosomes 13, 18, 21, X/Y were assessed using fluorescence in-situ hybridization (FISH) techniques (mean of 1223 sperm). RESULTS: There was no significant difference in any patient, seminal, cycle or laboratory characteristic between groups that may have affected outcome. Total AR (2.37 versus 1.18%, P 5 0.01), as well as AR of chromosomes 18, X/Y and 18 1 X/Y (1.48 versus 0.67%, P 5 0.005) were significantly higher in Group B compared with Group A. Regression analysis confirmed these differences to be independent of other variables and showed a 2.6-fold change in odds of achieving a pregnancy for every 1% change in total AR. CONCLUSIONS: Our findings confirm a potential role for aneuploidy testing in the work-up of ICSI patients as a predictor of success, as well as in future genetic counselling. If confirmed, there may also be a place for a study of preimplantation genetic screening to improve ICSI success in men found to have high AR and ICSI failure.

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Section: Discussionsupporting

confidence: 54%

The role of sperm aneuploidy as a predictor of the success of intracytoplasmic sperm injection?

et al. 2007

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“…These results suggest an implication of sperm chromosome abnormalities in some cases of recurrent pregnancy loss. Later, other studies corroborated this hypothesis, reporting an increase in sex chromosome disomies and diploid spermatozoa in couples with recurrent miscarriage (Al-Hassan et al, 2005;Bernardini et al, 2004;Giorlandino et al, 1998;Rubio et al, 2001). Finally, a recent study described that approximately 66% of abnormal karyotypes from miscarriages originate from male factor (Kim et al, 2010).…”

Section: Miscarriagesupporting

confidence: 63%

Human Male Meiosis and Sperm Aneuploidies

Vera¹,

Peinado²,

Al‐Asmar³

et al. 2012

Aneuploidy in Health and Disease

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“…High rates of sperm chromosomal abnormalities have been observed in RM patients with normal lympocyte karyotypes (16,17). As this study was performed using DNA extracted from peripheral blood, the possibility remains that abnormalities leading to miscarriage have arisen in the spermatozytes through de novo mutations during spermatogenesis.…”

Section: Figurementioning

confidence: 99%

“…In addition, men with low sperm counts show a higher incidence of sperm chromosomal abnormalities (15). An elevated rate of sperm chromosome abnormalities has also been found in some men of RM couples (16,17). Therfore, Dewan and coworkers (5) conducted a study to determine if Y chromosome microdeletions are associated with RM.…”

mentioning

confidence: 95%