Sperm cellular and nuclear dynamics associated with bull fertility

Kutchy, Naseer A.; Menezes, Erika Bezerra de; Ugur, Muhammet Rasit; Husna, Asma Ul; Eldebaky, H. A. A.; Evans, Holly; Beaty, E. R.; Santos, Fágner Cavalcante Patrocínio dos; Wang, Tan; Wills, Robert W.; Topper, Einko; Kaya, Abdullah; Moura, Arlindo A.; Memili, Erdoğan

doi:10.1016/j.anireprosci.2019.106203

Cited by 15 publications

(12 citation statements)

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“…A major upheaval occurs during and immediately after the fertilization period: the DNA of the zygote genome is thought to be rapidly de-methylated immediately postfertilization, and human in vitro fertilized IVF embryos apparently follow this scheme. High sperm methylation and retained methylation of the paternal genome represent major markers of fertility [6][7][8]. The observation that isoforms affecting the one-carbon and folate cycles have a negative impact on fertility confirms the importance of a high methylation status in sperm.…”

Section: The Beginning Of Life: Fertilization and Immediately Postfermentioning

confidence: 96%

“…As mentioned earlier, global methylation in the sperm nucleus (DNA and histones) provides the key for correct spatial and biochemical conformation that will allow rapid access to the paternal genome after nuclear swelling in the sperm head [7,8]. This feature is mandatory for rapid S-phase activation and the major methylation/epigenetic modifications that will modify the male genome.…”

Section: The Beginning Of Life: Fertilization and Immediately Postfermentioning

confidence: 96%

“…During spermatogenesis, DNA methylation is active during spermatogonial mitosis and meiosis and less active during spermiogenesis [58]. Histone methylation has an immediate effect during fertilization; it exerts a positive effect on the embryonic S-phase and on subsequent preimplantation development [7,8]. It is now recognized that pathologies can be transmitted across generations via epimutations that occur in adult gametogenesis [59][60][61][62][63].…”

Section: Methylation Errors In the Malementioning

confidence: 99%

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Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

Ménézo¹,

Clément²,

Clément³

et al. 2020

IJMS

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Methylation is a universal biochemical process which covalently adds methyl groups to a variety of molecular targets. It plays a critical role in two major global regulatory mechanisms, epigenetic modifications and imprinting, via methyl tagging on histones and DNA. During reproduction, the two genomes that unite to create a new individual are complementary but not equivalent. Methylation determines the complementary regulatory characteristics of male and female genomes. DNA methylation is executed by methyltransferases that transfer a methyl group from S-adenosylmethionine, the universal methyl donor, to cytosine residues of CG (also designated CpG). Histones are methylated mainly on lysine and arginine residues. The methylation processes regulate the main steps in reproductive physiology: gametogenesis, and early and late embryo development. A focus will be made on the impact of assisted reproductive technology and on the impact of endocrine disruptors (EDCs) via generation of oxidative stress.

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Section: The Beginning Of Life: Fertilization and Immediately Postfermentioning

confidence: 96%

Section: The Beginning Of Life: Fertilization and Immediately Postfermentioning

confidence: 96%

Section: Methylation Errors In the Malementioning

confidence: 99%

See 1 more Smart Citation

Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

Ménézo¹,

Clément²,

Clément³

et al. 2020

IJMS

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“…The current knowledge in humans about the different epigenetic signals in sperm that are responsive to environment and evidence of sperm-borne epigenetic factors is well-reviewed in Donkin and Barres (2018). In cattle, studies using sperm samples from low and high fertility bulls have suggested various sperm factors associated with bull fertility, including sperm proteomics, gene expression, sperm protamine status, macromolecules, metabolomics, superoxide dismutase, and amino acids of seminal plasma (Peddinti et al, 2008;Feugang et al, 2010;Govindaraju et al, 2012a;De Oliveira et al, 2013;Dogan et al, 2015;Grant et al, 2015;Kaya and Memili, 2016;Kutchy et al, 2017Kutchy et al, , 2019Velho et al, 2018Velho et al, , 2019Viana et al, 2018;Menezes et al, 2019;Ugur et al, 2019;Memili et al, 2020).…”

Section: Epigenetic Modifications Associated With Sperm Fertility In mentioning

confidence: 99%

The Epigenetics of Gametes and Early Embryos and Potential Long-Range Consequences in Livestock Species—Filling in the Picture With Epigenomic Analyses

2021

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The epigenome is dynamic and forged by epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA species. Increasing lines of evidence support the concept that certain acquired traits are derived from environmental exposure during early embryonic and fetal development, i.e., fetal programming, and can even be “memorized” in the germline as epigenetic information and transmitted to future generations. Advances in technology are now driving the global profiling and precise editing of germline and embryonic epigenomes, thereby improving our understanding of epigenetic regulation and inheritance. These achievements open new avenues for the development of technologies or potential management interventions to counteract adverse conditions or improve performance in livestock species. In this article, we review the epigenetic analyses (DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs) of germ cells and embryos in mammalian livestock species (cattle, sheep, goats, and pigs) and the epigenetic determinants of gamete and embryo viability. We also discuss the effects of parental environmental exposures on the epigenetics of gametes and the early embryo, and evidence for transgenerational inheritance in livestock.

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“…Using immunofluorescence, Western blotting, and flow cytometry, Kutchy et al ( 164 ) determined the associations between expression of the testis-specific histone variant 2B in sperm and bull fertility. Moreover, sperm chromatin damage and abnormal protamination were reported to be associated with reduced fertility in bulls using immunofluorescence, Western blotting, and chromatin dispersion tests ( 165 , 166 ). In addition, using flow cytometry and immunocytochemistry, methylation and acetylation of sperm histone 3 lysine 27 (H3K27me3 and H3K27ac) were shown to be associated with bull fertility ( 167 ).…”

Section: Sperm Epigenome and Bull Fertilitymentioning

confidence: 99%

Sperm Functional Genome Associated With Bull Fertility

et al. 2021

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Bull fertility is an important economic trait in sustainable cattle production, as infertile or subfertile bulls give rise to large economic losses. Current methods to assess bull fertility are tedious and not totally accurate. The massive collection of functional data analyses, including genomics, proteomics, metabolomics, transcriptomics, and epigenomics, helps researchers generate extensive knowledge to better understand the unraveling physiological mechanisms underlying subpar male fertility. This review focuses on the sperm phenomes of the functional genome and epigenome that are associated with bull fertility. Findings from multiple sources were integrated to generate new knowledge that is transferable to applied andrology. Diverse methods encompassing analyses of molecular and cellular dynamics in the fertility-associated molecules and conventional sperm parameters can be considered an effective approach to determine bull fertility for efficient and sustainable cattle production. In addition to gene expression information, we also provide methodological information, which is important for the rigor and reliability of the studies. Fertility is a complex trait influenced by several factors and has low heritability, although heritability of scrotal circumference is high and that it is a known fertility maker. There is a need for new knowledge on the expression levels and functions of sperm RNA, proteins, and metabolites. The new knowledge can shed light on additional fertility markers that can be used in combination with scrotal circumference to predict the fertility of breeding bulls. This review provides a comprehensive review of sperm functional characteristics or phenotypes associated with bull fertility.

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Sperm cellular and nuclear dynamics associated with bull fertility

Cited by 15 publications

References 58 publications

Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life

The Epigenetics of Gametes and Early Embryos and Potential Long-Range Consequences in Livestock Species—Filling in the Picture With Epigenomic Analyses

Sperm Functional Genome Associated With Bull Fertility

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