Sperm banking for male reproductive preservation: a 6-year retrospective multi-centre study in China

Abstract

Sperm banking can preserve male fertility effectively, but the current conditions of sperm cryopreservation in China have not been investigated. This retrospective investigation was based on data collected at multiple centres in China from January 2003 to December 2008. The collected data included urogenital history, indication for cryopreservation, semen parameters, use rate, type of assisted reproductive technique (ART) treatment and pregnancy outcome. The study population included 1 548 males who had banked their semen during the study period at one of the clinics indicated above. Approximately 1.9% (30/1 548) of the cryopreserved semen samples were collected from cancer patients; about 88.8% (1 374/1 548) of the patients had banked their semen for ART and 8.6% (134/1 548) had a male infertility disease (such as anejaculation, severe oligozoospermia and obstructive azoospermia). The total use rate of cryopreserved semen was 22.7% (352/1 548), with 119 live births. The cancer group use rate was 6.7% (2/30), with one live birth by intracytoplasmic single sperm injection (ICSI). The ART group use rate was 23.2% (319/1 374), with 106 live births. The reproductive disease group use rate was 23.1% (31/134), with 12 live births. The semen parameters in each category varied; the cancer patient and infertility disease groups had poor semen quality. In vitro fertilization (IVF) and ICSI were the most common ART treatments for cryopreserved sperm. Semen cryopreservation as a salvage method is effective, but in many conditions it is underutilized, especially in cancer patients. Lack of awareness, urgency of cancer treatment and financial constraints are the main causes of the low access rate. The concept of fertility preservation should be popularized to make better use of this medical service in China.

Effects of oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders

“…The development of several assisted reproduction techniques, including semen cryopreservation, has brought effective and qualitative changes in this field. 1, 2 Every year 6500 men aged 15-39 years develop cancer in Italy. In particular, malignant testicular neoplasias (TN) represent 16% of all new cancer diagnoses (incidence of 10.2/100 000 inhabitants), followed by Hodgkin lymphomas and non-Hodgkin lymphomas (respective incidence of 5.0/100 000 and 6.2/100 000).…”

Sperm donation and its application in China: a 7-year multicenter retrospective study

“…All human sperm banks are state-owned and perform the following tasks: (i) organize and screen sperm donors, cryopreserve semen samples and provide these to qualified reproductive clinics; (ii) cryostore sperm to preserve male fertility for those who need it; 3 and (iii) perform scientific research on reproductive health. A standard protocol for human sperm banking was initiated in 2001 by the Chinese Ministry of Health.…”

Sperm dondurma: Güncel gelişmeler

“…Örneğin bir çalışmada, 64 erkek olgunun sadece %15,6'sı gebelik sağlamak için ilişkiye girdiğini belirtmiştir. [65] İlk sperm bankasının 1953 yılında Sherman tarafından kurulmasından sonra sperm dondurma açısından oldukça önemli ilerlemeler sağlanmıştır. Toplam 1113 makaleden 44'ünün incelendiği bir araştırmada kanserli hastalarda sperm dondurulanlardaki gebelik sperm dondurmayanlara göre daha yüksek saptanmıştır.…”